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Search results 1 to 3 out of 3 for Herc2

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: This entry represents the ZZ type zinc finger found in HERC2 and related proteins. HERC2 is an E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes []. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding [, , ].
Protein Domain
Type: Domain
Description: This entry represents the APC10/DOC1 domain of HERC2 (HECT domain and RLD2). This domain is similar to the anaphase-promoting complex subunit APC10 and the DOC1 domain present in E3 ubiquitin ligases which mediate substrate ubiquitination (or ubiquitylation) []. HERC2 may be involved in protein trafficking and degradation pathways. Mutations in HERC2 lead to neuromuscular secretory vesicle and sperm acrosome defects, other developmental abnormalities, and juvenile lethality of jdf2 mice []. It has been shown that the HERC2-RNF8 protein complex coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes [].
Protein Domain
Type: Domain
Description: The CPH domain is found in the Cullin-7, PARC and HERC2 proteins, which are all components of known or predicted E3-ubiquitin ligases. The CPH domain is a protein-protein interaction module that binds the teramerisation domain of the tumour suppressor protein p53 []. Structurally it forms a β-barrel fold similar to the SH3, Tudor and KOW and domains. Unlike the SH3 and Tudor domains, which bind to small peptides, the CPH domain appears to bind to an extended surface on p53.