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Search results 101 to 165 out of 165 for Prdm6

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:3852026
Assay Type: RNA in situ
Annotation Date: 2009-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3852139
Age: embryonic day 11.5
Image: 3G
Note: In the ventral spinal cord, expression was detected in a small subset of postmitotic neurons.
Specimen Label: 3G
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3641083
Age: embryonic day 15.5
Specimen Label: 2F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3641083
Age: embryonic day 15.5
Note: Expression is present in the lamina propria of the bladder.
Specimen Label: 2G
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3641083
Age: embryonic day 11.5
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6469599
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6469613
Age: embryonic day 14.5
Note: Expression is in the smooth muscle cells of the aorta.
Specimen Label: 6C E14.5 left
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:6469599
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6469613
Age: embryonic day 14.5
Note: Expression is in the smooth muscle cells of the aorta.
Specimen Label: 6C E14.5 right
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3641083
Age: embryonic day 13.5
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3852026
Assay Type: RNA in situ
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1715219
Stage: TS19
Assay Id: MGI:3852139
Age: embryonic day 11.5
Image: 3G
Specimen Label: 3G
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3269626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:3641083
Age: embryonic day 18.5
Note: Expression is present in the smooth muscle surrounding the bronchi of the lung.
Specimen Label: 2I
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1701523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3641083
Age: embryonic day 15.5
Specimen Label: 2J
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3641072
Assay Type: RNA in situ
Annotation Date: 2006-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1701523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3641083
Age: embryonic day 15.5
Note: Expression is present in the smooth muscle layer.
Specimen Label: 2K
Detected: true
Specimen Num: 8
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Gene
110438465 | LOC110438465
Type: gene
Organism: zebrafish
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Publication
24563856 | J:295002
 
First Author: Mohar I
Year: 2014
Journal: Redox Biol
Title: Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Volume: 2
Pages: 377-87
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Publication
19050759 | J:144373
First Author: Kinameri E
Year: 2008
Journal: PLoS One
Title: Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.
Volume: 3
Issue: 12
Pages: e3859
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Publication
19097117 | J:142646
First Author: Yi L
Year: 2009
Journal: Dev Dyn
Title: Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung.
Volume: 238
Issue: 1
Pages: 123-37
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Publication
21282332 | J:247466
First Author: Kirchhof P
Year: 2011
Journal: Circ Cardiovasc Genet
Title: PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Volume: 4
Issue: 2
Pages: 123-33
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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HT Experiment
GSE9065 | Investigation of the physiological functions of PRDM6
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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UniProt Feature
UniProt Feature
Begin: 1
Description: Putative histone-lysine N-methyltransferase PRDM6
Type: chain
End: 596
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HT Experiment
GSE221004 | Effect of smooth muscle specific PRDM6 depletion on Aorta and Ductus Arterious (DA) development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36602864 | J:333395
 
First Author: Gunawardhana KL
Year: 2023
Journal: J Clin Invest
Title: A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension.
Volume: 133
Issue: 4
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Protein
Q3UZD5
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Protein
Q3UZD5-4
Organism: Mus musculus/domesticus
Length: 565  
Fragment?: false
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Protein
Q3UZD5-3
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
Q3UZD5-2
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A494BAI6
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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HT Experiment
GSE195589 | Single cell RNA-seq analysis of CNCCs at embryonic E9.5
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR044416 | PRDM6_PR-SET
Type: Domain
Description: This entry represents the PR/SET domain found in PR domain zinc finger protein 6 (PRDM6, also known as PRISM). PRDM6 has been shown to co-localized with histone H4 and methylates H4-K20 []. It has also been shown to act as a transcriptional repressor by interacting with class I histone deacetylases and the G9a histone methyltransferase []. It promotes thetransition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells []. It also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation []. Mutations in the PRDM6 gene have been linked to nonsyndromic patent ductus arteriosus (PDA), which is a common congenital heart defect (CHD) with both inherited and acquired causes [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes [].
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Publication
21604305 | -
First Author: Briknarová K
Year: 2011
Journal: Proteins
Title: The PR/SET domain in PRDM4 is preceded by a zinc knuckle.
Volume: 79
Issue: 7
Pages: 2341-5
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Protein Domain
IPR041493 | PRDM4_Znf_knuckle
Type: Domain
Description: This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a β-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two β-hairpins, each providing two zinc ligands) [].
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Publication
37198424 | J:335822
First Author: Capriati M
Year: 2023
Journal: Sci Rep
Title: Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.
Volume: 13
Issue: 1
Pages: 8003
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Protein
D3YYH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
D3Z7Q9
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
24095733 | J:277873
First Author: Wu H
Year: 2013
Journal: Cell Rep
Title: Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.
Volume: 5
Issue: 1
Pages: 13-20
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Publication
32290321 | -
 
First Author: Casamassimi A
Year: 2020
Journal: Int J Mol Sci
Title: Multifaceted Role of PRDM Proteins in Human Cancer.
Volume: 21
Issue: 7
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Protein
Q80V63
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: false
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Protein
Q8C0V8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
A0A1X7SB67
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Protein
Q8R3B9
Organism: Mus musculus/domesticus
Length: 743  
Fragment?: true
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Protein
B7ZP41
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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