This entry includes C2 domain-containing protein 2 (C2CD2) and C2CD2-like (C2CD2L) proteins. C2CD2L, also known as TMEM24, is an endoplasmic reticulum (ER)-anchored membrane protein that binds lipids and transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]precursor phosphatidylinositol between bilayers, allowing replenishment of PI(4,5)P2 hydrolyzed during signaling []. The function of C2CD2 is not known.
