|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1001 to 1081 out of 1081 for Htt

<< First    < Previous  |  Next >    Last >>
0.031s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
21217767 | J:186963
First Author: Richards P
Year: 2011
Journal: Cell Death Differ
Title: Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Volume: 18
Issue: 2
Pages: 191-200
•
•
•
•
•
Publication
20668093 | J:164450
First Author: Chiang MC
Year: 2010
Journal: Hum Mol Genet
Title: Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.
Volume: 19
Issue: 20
Pages: 4043-58
•
•
•
•
•
Publication
23796713 | J:205328
First Author: Das E
Year: 2013
Journal: Biochem Biophys Res Commun
Title: MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells.
Volume: 437
Issue: 2
Pages: 217-24
•
•
•
•
•
Publication
28182673 | J:248017
First Author: Datson NA
Year: 2017
Journal: PLoS One
Title: The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain.
Volume: 12
Issue: 2
Pages: e0171127
•
•
•
•
•
Publication
24670645 | J:210468
First Author: Paul BD
Year: 2014
Journal: Nature
Title: Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease.
Volume: 509
Issue: 7498
Pages: 96-100
•
•
•
•
•
Publication
23409115 | J:198315
First Author: Li M
Year: 2013
Journal: PLoS One
Title: Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease.
Volume: 8
Issue: 2
Pages: e56026
•
•
•
•
•
Publication
23416527 | J:202434
First Author: Lin YS
Year: 2013
Journal: Biochim Biophys Acta
Title: Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease.
Volume: 1832
Issue: 6
Pages: 742-53
•
•
•
•
•
Publication
22187438 | J:184100
First Author: Gupta S
Year: 2012
Journal: J Biol Chem
Title: Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay.
Volume: 287
Issue: 13
Pages: 9982-9
•
•
•
•
•
Publication
16326808 | J:104367
First Author: Jin K
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease.
Volume: 102
Issue: 50
Pages: 18189-94
•
•
•
•
•
Publication
33420088 | J:300300
First Author: Kumar MJV
Year: 2021
Journal: Sci Rep
Title: Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model.
Volume: 11
Issue: 1
Pages: 96
•
•
•
•
•
Publication
24475300 | J:212703
First Author: Safren N
Year: 2014
Journal: PLoS One
Title: Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.
Volume: 9
Issue: 1
Pages: e87513
•
•
•
•
•
Publication
16595660 | J:113725
First Author: Qiu Z
Year: 2006
Journal: J Biol Chem
Title: Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.
Volume: 281
Issue: 24
Pages: 16672-80
•
•
•
•
•
Publication
32622701 | J:297610
 
First Author: Skotte NH
Year: 2020
Journal: Exp Neurol
Title: Compromised IGF signaling causes caspase-6 activation in Huntington disease.
Volume: 332
Pages: 113396
•
•
•
•
•
Publication
23392662 | J:327891
First Author: Taylor DM
Year: 2013
Journal: J Neurosci
Title: MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
Volume: 33
Issue: 6
Pages: 2313-25
•
•
•
•
•
Publication
22383888 | J:183404
First Author: Bañez-Coronel M
Year: 2012
Journal: PLoS Genet
Title: A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.
Volume: 8
Issue: 2
Pages: e1002481
•
•
•
•
•
Publication
32702387 | J:300561
 
First Author: Rolfes S
Year: 2020
Journal: Neurobiol Dis
Title: Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease.
Volume: 144
Pages: 105024
•
•
•
•
•
Publication
19605647 | J:151692
First Author: Wacker JL
Year: 2009
Journal: J Neurosci
Title: Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
Volume: 29
Issue: 28
Pages: 9104-14
•
•
•
•
•
Publication
21515588 | J:173756
First Author: Tebbenkamp AT
Year: 2011
Journal: Hum Mol Genet
Title: Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Volume: 20
Issue: 14
Pages: 2770-82
•
•
•
•
•
Publication
28114340 | J:238696
First Author: Nakasuji T
Year: 2017
Journal: PLoS Genet
Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
Volume: 13
Issue: 1
Pages: e1006578
•
•
•
•
•
Publication
22179319 | J:180780
First Author: Jiang M
Year: 2011
Journal: Nat Med
Title: Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Volume: 18
Issue: 1
Pages: 153-8
•
•
•
•
•
Publication
28939435 | J:256872
First Author: Silva AC
Year: 2018
Journal: Biochim Biophys Acta
Title: Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease.
Volume: 1864
Issue: 1
Pages: 34-44
•
•
•
•
•
Publication
29462355 | J:261420
First Author: Zhou X
Year: 2018
Journal: Hum Mol Genet
Title: Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.
Volume: 27
Issue: 9
Pages: 1545-1555
•
•
•
•
•
Publication
18400759 | J:137552
First Author: Orr AL
Year: 2008
Journal: J Biol Chem
Title: Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.
Volume: 283
Issue: 23
Pages: 16027-36
•
•
•
•
•
Publication
25351248 | J:259054
First Author: Pryor WM
Year: 2014
Journal: Sci Signal
Title: Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
Volume: 7
Issue: 349
Pages: ra103
•
•
•
•
•
Publication
17940007 | J:125948
First Author: DiFiglia M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
Volume: 104
Issue: 43
Pages: 17204-9
•
•
•
•
•
Publication
19244517 | J:145946
First Author: Joshi PR
Year: 2009
Journal: J Neurosci
Title: Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease.
Volume: 29
Issue: 8
Pages: 2414-27
•
•
•
•
•
Publication
26485309 | J:228643
 
First Author: Moreno CL
Year: 2016
Journal: Neurobiol Dis
Title: Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.
Volume: 85
Pages: 25-34
•
•
•
•
•
Publication
24324398 | J:290067
 
First Author: Czeredys M
Year: 2013
Journal: Front Mol Neurosci
Title: Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.
Volume: 6
Pages: 42
•
•
•
•
•
Publication
26041817 | J:223372
First Author: Hamilton J
Year: 2015
Journal: Hum Mol Genet
Title: Oxidative metabolism in YAC128 mouse model of Huntington's disease.
Volume: 24
Issue: 17
Pages: 4862-78
•
•
•
•
•
Publication
17409241 | J:119402
First Author: Fan MM
Year: 2007
Journal: J Neurosci
Title: Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.
Volume: 27
Issue: 14
Pages: 3768-79
•
•
•
•
•
Publication
19726651 | J:152453
First Author: Fan J
Year: 2009
Journal: J Neurosci
Title: Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.
Volume: 29
Issue: 35
Pages: 10928-38
•
•
•
•
•
Publication
18753376 | J:138790
First Author: Kaminosono S
Year: 2008
Journal: J Neurosci
Title: Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.
Volume: 28
Issue: 35
Pages: 8747-55
•
•
•
•
•
Publication
22127389 | J:182049
First Author: Roux JC
Year: 2012
Journal: Neurobiol Dis
Title: Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway.
Volume: 45
Issue: 2
Pages: 786-95
•
•
•
•
•
Publication
23223017 | J:193291
First Author: Valencia A
Year: 2013
Journal: Hum Mol Genet
Title: Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.
Volume: 22
Issue: 6
Pages: 1112-31
•
•
•
•
•
Publication
21307087 | J:170341
First Author: Tebbenkamp AT
Year: 2011
Journal: Hum Mol Genet
Title: Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment.
Volume: 20
Issue: 8
Pages: 1633-42
•
•
•
•
•
Publication
22056561 | J:179211
First Author: Bauer PO
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation.
Volume: 416
Issue: 1-2
Pages: 13-7
•
•
•
•
•
Publication
22179316 | J:180782
First Author: Jeong H
Year: 2011
Journal: Nat Med
Title: Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
Volume: 18
Issue: 1
Pages: 159-65
•
•
•
•
•
Publication
23614720 | J:199199
First Author: Costanzo M
Year: 2013
Journal: Biochem J
Title: The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration.
Volume: 452
Issue: 1
Pages: 1-17
•
•
•
•
•
Publication
24070868 | J:204999
First Author: Ehrnhoefer DE
Year: 2014
Journal: Hum Mol Genet
Title: p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Volume: 23
Issue: 3
Pages: 717-29
•
•
•
•
•
Publication
26358776 | J:226493
First Author: Sassone F
Year: 2015
Journal: Hum Mol Genet
Title: Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin.
Volume: 24
Issue: 22
Pages: 6530-9
•
•
•
•
•
Publication
29079832 | J:255558
First Author: Bondulich MK
Year: 2017
Journal: Sci Rep
Title: Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.
Volume: 7
Issue: 1
Pages: 14275
•
•
•
•
•
Publication
30538129 | J:275339
First Author: Son S
Year: 2019
Journal: J Biol Chem
Title: High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.
Volume: 294
Issue: 6
Pages: 1915-1923
•
•
•
•
•
Publication
36439204 | J:331951
 
First Author: Zhao X
Year: 2022
Journal: Front Cell Neurosci
Title: Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice.
Volume: 16
Pages: 1021592
•
•
•
•
•
Publication
21715619 | J:174060
First Author: Xiang Z
Year: 2011
Journal: J Neurosci
Title: Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease.
Volume: 31
Issue: 26
Pages: 9544-53
•
•
•
•
•
Publication
23238740 | J:192012
First Author: Bouchard J
Year: 2012
Journal: J Neurosci
Title: Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.
Volume: 32
Issue: 50
Pages: 18259-68
•
•
•
•
•
Publication
17329427 | J:119798
First Author: Metzler M
Year: 2007
Journal: J Neurosci
Title: NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.
Volume: 27
Issue: 9
Pages: 2298-308
•
•
•
•
•
Publication
30107216 | J:268841
     
First Author: Boussicault L
Year: 2018
Journal: Biochimie
Title: CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content.
•
•
•
•
•
Publication
26025364 | J:243843
First Author: O'Brien R
Year: 2015
Journal: J Biol Chem
Title: Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.
Volume: 290
Issue: 31
Pages: 19287-306
•
•
•
•
•
Publication
20736066 | J:167257
First Author: Hathorn T
Year: 2011
Journal: Neurobiol Dis
Title: Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease.
Volume: 41
Issue: 1
Pages: 43-50
•
•
•
•
•
Publication
29056363 | J:261947
First Author: Luis-Ravelo D
Year: 2018
Journal: Exp Neurol
Title: Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease.
Volume: 299
Issue: Pt A
Pages: 137-147
•
•
•
•
•
Publication
24367693 | J:211131
First Author: Rattray I
Year: 2013
Journal: PLoS One
Title: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/1 mouse model of Huntington's disease.
Volume: 8
Issue: 12
Pages: e84726
•
•
•
•
•
Publication
23593159 | J:200037
First Author: Rattray I
Year: 2013
Journal: PLoS One
Title: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/2 mouse model of HD.
Volume: 8
Issue: 4
Pages: e60012
•
•
•
•
•
Publication
37415834 | J:346962
 
First Author: Gasser J
Year: 2023
Journal: Front Mol Neurosci
Title: Innate immune activation and aberrant function in the R6/2 mouse model and Huntington's disease iPSC-derived microglia.
Volume: 16
Pages: 1191324
•
•
•
•
•
Publication
24698979 | J:213622
First Author: Hsiao HY
Year: 2014
Journal: Hum Mol Genet
Title: Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.
Volume: 23
Issue: 16
Pages: 4328-44
•
•
•
•
•
Publication
21887328 | J:176149
First Author: Ghose J
Year: 2011
Journal: PLoS One
Title: Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease.
Volume: 6
Issue: 8
Pages: e23837
•
•
•
•
•
Publication
27820862 | J:253188
First Author: Hering T
Year: 2016
Journal: PLoS One
Title: Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease.
Volume: 11
Issue: 11
Pages: e0166106
•
•
•
•
•
Publication
20145253 | J:161176
First Author: Bradford J
Year: 2010
Journal: J Biol Chem
Title: Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
Volume: 285
Issue: 14
Pages: 10653-61
•
•
•
•
•
Publication
7868888 | J:35859
First Author: Wettstein PJ
Year: 1995
Journal: J Immunol
Title: Murine minor histocompatibility antigens detected by helper T cells. Recognition of an endogenous peptide.
Volume: 154
Issue: 5
Pages: 2134-43
•
•
•
•
•
Publication
23089356 | J:197496
 
First Author: Conforti P
Year: 2013
Journal: Neurobiol Dis
Title: Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.
Volume: 50
Pages: 160-70
•
•
•
•
•
Publication
24204323 | J:205134
First Author: Pinto RM
Year: 2013
Journal: PLoS Genet
Title: Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Volume: 9
Issue: 10
Pages: e1003930
•
•
•
•
•
Publication
32439598 | J:299192
 
First Author: Sapp E
Year: 2020
Journal: Neurobiol Dis
Title: Protein changes in synaptosomes of Huntington's disease knock-in mice are dependent on age and brain region.
Volume: 141
Pages: 104950
•
•
•
•
•
Publication
35095420 | J:319720
 
First Author: Floreani L
Year: 2021
Journal: Front Cell Neurosci
Title: Analysis of LINE1 Retrotransposons in Huntington's Disease.
Volume: 15
Pages: 743797
•
•
•
•
•
Publication
24784230 | J:208675
First Author: Wang N
Year: 2014
Journal: Nat Med
Title: Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
Volume: 20
Issue: 5
Pages: 536-41
•
•
•
•
•
Publication
26508634 | J:227256
First Author: Pancani T
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Volume: 112
Issue: 45
Pages: 14078-83
•
•
•
•
•
Publication
23616545 | J:196945
First Author: Cepeda C
Year: 2013
Journal: J Neurosci
Title: Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models.
Volume: 33
Issue: 17
Pages: 7393-406
•
•
•
•
•
Publication
21273402 | J:248620
First Author: André VM
Year: 2011
Journal: J Neurosci
Title: Differential electrophysiological changes in striatal output neurons in Huntington's disease.
Volume: 31
Issue: 4
Pages: 1170-82
•
•
•
•
•
Publication
30292559 | J:268700
 
First Author: Dufour BD
Year: 2019
Journal: Neurobiol Dis
Title: Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington's disease.
Volume: 121
Pages: 214-229
•
•
•
•
•
Publication
32954323 | J:324738
First Author: Landles C
Year: 2020
Journal: Brain Commun
Title: Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.
Volume: 2
Issue: 2
Pages: fcaa066
•
•
•
•
•
Publication
29883458 | J:262995
First Author: Novati A
Year: 2018
Journal: PLoS One
Title: Sexual behavior and testis morphology in the BACHD rat model.
Volume: 13
Issue: 6
Pages: e0198338
•
•
•
•
•
Publication
33310753 | J:301525
First Author: Caron NS
Year: 2021
Journal: J Neurosci
Title: Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Volume: 41
Issue: 4
Pages: 780-796
•
•
•
•
•
Protein
H3BKQ0
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
•
•
•
•
•
Publication
14603322 | J:86437
First Author: Huangfu D
Year: 2003
Journal: Nature
Title: Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Volume: 426
Issue: 6962
Pages: 83-7
•
•
•
•
•
Publication
22633949 | J:207069
 
First Author: Nithianantharajah J
Year: 2013
Journal: Neuroscience
Title: Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease.
Volume: 251
Pages: 66-74
•
•
•
•
•
Publication
35114102 | J:319519
     
First Author: Gu X
Year: 2022
Journal: Neuron
Title: Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
•
•
•
•
•
Protein
A2AFJ8
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
•
•
•
•
•
Publication
16024820 | J:100332
First Author: Wilson L
Year: 2005
Journal: Genome Res
Title: Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.
Volume: 15
Issue: 8
Pages: 1095-105
•
•
•
•
•
Protein
D3Z0V2
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: true
•
•
•
•
•
Protein
A0A0R4J0X8
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
•
•
•
•
•
Protein
Q9ES28
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q8K4I3
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
•
•
•
•
•
Protein
F6WMJ3
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom