Neurogenic differentiation factor 6 (Neurod6) is a basic helix-loop-helix (bHLH) transcription factor involved in the development and maintenance of the nervous system. It regulates cortical commissure formation before midline interactions during corpus callosum development []. Neurod6 possesses mitochondrial biogenic properties by amplifying the mitochondrial DNA content and TFAM expression levels, a key regulator for mitochondrial biogenesis []. Downregulation of NeuroD6 has been linked to Alzheimer's disease [, ].The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [].
