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Search results 101 to 129 out of 129 for Pnpla3

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0.018s

Type

Details

Score

Strain

MGI:6429382 | C57BL/6J-Pnpla3<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

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Publication

19029121 | -

First Author:	Kienesberger PC
Year:	2009
Journal:	J Lipid Res
Title:	Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.
Volume:	50 Suppl

Pages:	S63-8

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Publication

16799181 | -

First Author:	Wilson PA
Year:	2006
Journal:	J Lipid Res
Title:	Characterization of the human patatin-like phospholipase family.
Volume:	47
Issue:	9
Pages:	1940-9

•

Publication

36103835 | J:329333

First Author:	Kabbani M
Year:	2022
Journal:	Cell Rep
Title:	Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice.
Volume:	40
Issue:	11
Pages:	111321

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Publication

26083785 | -

First Author:	Xie M
Year:	2015
Journal:	PLoS Genet
Title:	The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.
Volume:	11
Issue:	6
Pages:	e1005284

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Publication

19052547 | -

First Author:	Narbonne P
Year:	2009
Journal:	Nature
Title:	Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Volume:	457
Issue:	7226
Pages:	210-4

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Publication

20176933 | -

First Author:	Zhang SO
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Volume:	107
Issue:	10
Pages:	4640-5

•

Publication

24120942 | -

First Author:	Noble T
Year:	2013
Journal:	Cell Metab
Title:	An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Volume:	18
Issue:	5
Pages:	672-84

•

Publication

25202121 | -

First Author:	Lee JH
Year:	2014
Journal:	Mol Cell Biol
Title:	Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
Volume:	34
Issue:	22
Pages:	4165-76

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Publication

26098762 | -

First Author:	Xie M
Year:	2015
Journal:	PLoS One
Title:	AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae.
Volume:	10
Issue:	6
Pages:	e0130480

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Protein Domain

IPR033562 | PLPL

Type:

Family

Description:

This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases. Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [, , , , , ]. In humans PNPLA1 has a role in the formation of the epidermal lipid barrier; mutations in this gene are associated with the skin disorder known as ichthyosis []. PNPLA1 acts as an omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation [, ]. It catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramid [].Human PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets []. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [].

•

Publication

31813960 | J:285758

First Author:	Saeed A
Year:	2020
Journal:	Hum Mol Genet
Title:	Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels.
Volume:	29
Issue:	2
Pages:	264-273

•

Publication

23977068 | J:206346

First Author:	Kosters A
Year:	2013
Journal:	PLoS One
Title:	Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice.
Volume:	8
Issue:	8
Pages:	e71538

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Publication

31529722 | J:296056

First Author:	Matsuzaka T
Year:	2020
Journal:	Hepatology
Title:	Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
Volume:	71
Issue:	5
Pages:	1609-1625

•

Publication

15550674 | J:289460

First Author:	Zimmermann R
Year:	2004
Journal:	Science
Title:	Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Volume:	306
Issue:	5700
Pages:	1383-6

•

Publication

27751867 | J:240053

First Author:	Grond S
Year:	2017
Journal:	J Invest Dermatol
Title:	PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides.
Volume:	137
Issue:	2
Pages:	394-402

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Publication

22246504 | -

First Author:	Grall A
Year:	2012
Journal:	Nat Genet
Title:	PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans.
Volume:	44
Issue:	2
Pages:	140-7

•

Publication

28248318 | -

First Author:	Ohno Y
Year:	2017
Journal:	Nat Commun
Title:	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.
Volume:	8

Pages:	14610

•

Protein

Q3V1D5

Organism:	Mus musculus/domesticus
Length:	599
Fragment?:	false

•

Protein

Q32LZ8

Organism:	Mus musculus/domesticus
Length:	432
Fragment?:	false

•

Protein

E9PZA4

Organism:	Mus musculus/domesticus
Length:	305
Fragment?:	true

•

Protein

E9Q323

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	true

•

Protein

B2KF06

Organism:	Mus musculus/domesticus
Length:	599
Fragment?:	false

•

Protein

H3BIT5

Organism:	Mus musculus/domesticus
Length:	70
Fragment?:	false

•

Publication

15364929 | -

First Author:	Jenkins CM
Year:	2004
Journal:	J Biol Chem
Title:	Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Volume:	279
Issue:	47
Pages:	48968-75

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Protein

Q8BJ56

Organism:	Mus musculus/domesticus
Length:	486
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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