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Search results 501 to 551 out of 551 for Hnf1a

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Type Details Score
Publication
11158324 | J:67396
First Author: Hayhurst GP
Year: 2001
Journal: Mol Cell Biol
Title: Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Volume: 21
Issue: 4
Pages: 1393-403
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Protein Domain
IPR028318 | DYRK1A/B_MNB
Type: Family
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].
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Protein Domain
IPR044131 | PKc_DYR1A/1B
Type: Domain
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].This entry represents the catalytic domain found in DYRK1A and DYRK1B.
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Protein Domain
IPR039067 | HNF4A
Type: Family
Description: HNF4A (also known as TCF14) is a member of the steroid-thyroid hormone receptor superfamily. HNF4A interacts with regulatory elements in promoters and enhancers of the genes involved in cholesterol fatty acid and glucose metabolism [, ]. It is an upstream regulator of HNF1A expression []. HNF4A regulates the expression of genes in the liver, pancreas, kidney, intestine, and other tissues. It is essential for development of the liver [, ]and regulates growth and function of islet beta-cells in the pancreas [, ]. Mutations in the HFN4A gene result in type 1 MODY (MODY1), a monogenic form of non-insulin-dependent type 2 diabetes [, ]. HNF4A is also involved in circadian rhythm maintenance in liver and colon cells as it transrepresses CLOCK:BMAL1 heterodimer activity [].
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Publication
20123978 | J:161722
First Author: Kurabayashi N
Year: 2010
Journal: Mol Cell Biol
Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
Volume: 30
Issue: 7
Pages: 1757-68
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Publication
20167603 | J:165940
First Author: Guo X
Year: 2010
Journal: J Biol Chem
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Volume: 285
Issue: 17
Pages: 13223-32
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Publication
8769099 | -
First Author: Shindoh N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Volume: 225
Issue: 1
Pages: 92-9
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Publication
21156027 | -
First Author: Tejedor FJ
Year: 2011
Journal: FEBS J
Title: MNB/DYRK1A as a multiple regulator of neuronal development.
Volume: 278
Issue: 2
Pages: 223-35
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Publication
19685005 | -
First Author: Park J
Year: 2009
Journal: Cell Mol Life Sci
Title: Function and regulation of Dyrk1A: towards understanding Down syndrome.
Volume: 66
Issue: 20
Pages: 3235-40
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Publication
23809146 | -
First Author: Walte A
Year: 2013
Journal: FEBS J
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Volume: 280
Issue: 18
Pages: 4495-511
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Publication
8631952 | -
First Author: Kentrup H
Year: 1996
Journal: J Biol Chem
Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Volume: 271
Issue: 7
Pages: 3488-95
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Publication
22876196 | -
First Author: Hong SH
Year: 2012
Journal: PLoS Genet
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.
Volume: 8
Issue: 8
Pages: e1002857
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Publication
7857639 | J:37070
First Author: Tejedor F
Year: 1995
Journal: Neuron
Title: minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila.
Volume: 14
Issue: 2
Pages: 287-301
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Publication
11980910 | -
First Author: Lim S
Year: 2002
Journal: J Biol Chem
Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Volume: 277
Issue: 28
Pages: 25040-6
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Publication
14500717 | -
First Author: Zou Y
Year: 2003
Journal: J Biol Chem
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Volume: 278
Issue: 49
Pages: 49573-81
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Publication
10910078 | -
First Author: Lee K
Year: 2000
Journal: Cancer Res
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Volume: 60
Issue: 13
Pages: 3631-7
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Publication
25716801 | J:259974
 
First Author: Stepniewski J
Year: 2015
Journal: Sci Rep
Title: Induced pluripotent stem cells as a model for diabetes investigation.
Volume: 5
Pages: 8597
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Publication
34843575 | J:315178
First Author: Miyachi Y
Year: 2021
Journal: PLoS One
Title: Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.
Volume: 16
Issue: 11
Pages: e0260526
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Publication
20682686 | J:169619
First Author: Bonner C
Year: 2010
Journal: Diabetes
Title: INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.
Volume: 59
Issue: 11
Pages: 2799-808
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Publication
32171179 | J:320327
First Author: Konstandi M
Year: 2020
Journal: J Endocrinol
Title: Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice.
Volume: 245
Issue: 2
Pages: 301-314
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Publication
21841783 | J:176059
First Author: Ohtsubo K
Year: 2011
Journal: Nat Med
Title: Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
Volume: 17
Issue: 9
Pages: 1067-75
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HT Experiment
GSE236256 | Enhancer grammar of liver cell types and hepatocyte zonation states [multiome_validation]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE218465 | Enhancer grammar of liver cell types and hepatocyte zonation states [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE218468 | Enhancer grammar of liver cell types and hepatocyte zonation states [multiome]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
17407387 | J:134163
First Author: Pearson ER
Year: 2007
Journal: PLoS Med
Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
Volume: 4
Issue: 4
Pages: e118
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Publication
26857093 | J:321786
First Author: Wu W
Year: 2016
Journal: Hepatology
Title: Genome-wide association study in mice identifies loci affecting liver-related phenotypes including Sel1l influencing serum bile acids.
Volume: 63
Issue: 6
Pages: 1943-56
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Protein
A9C478
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q80ZK5
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
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Protein
H3BKV2
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q9Z188
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q61214
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
F6U6X3
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Protein
Q8K006
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: true
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Protein
A9C475
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
Q8C774
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
A1L341
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
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Protein
A0A0A0MQH4
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
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Protein
Q61158
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
F6XBL0
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
P22361
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
P49698
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
P27889
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
B9VVT6
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: true
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Protein
Q66JY7
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
B9VVT5
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
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Protein
Z4YKX0
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
Q2M4H2
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
H3BL72
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
A2A5I6
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
B9VVT7
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
A2ICG8
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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