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Search results 101 to 200 out of 271 for Trem2

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Type Details Score
Publication
31932797 | J:284722
First Author: Zhou Y
Year: 2020
Journal: Nat Med
Title: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Volume: 26
Issue: 1
Pages: 131-142
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Publication
36635449 | J:345475
First Author: Zhang K
Year: 2023
Journal: Nat Metab
Title: TREM2(hi) resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis.
Volume: 5
Issue: 1
Pages: 129-146
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Publication
34965428 | J:321071
First Author: Lee SH
Year: 2021
Journal: Cell Rep
Title: TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Volume: 37
Issue: 13
Pages: 110158
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Publication
15728241 | J:96626
First Author: Takahashi K
Year: 2005
Journal: J Exp Med
Title: Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
Volume: 201
Issue: 4
Pages: 647-57
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Publication
33603230 | J:305250
First Author: Dong Y
Year: 2021
Journal: Nat Neurosci
Title: Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia.
Volume: 24
Issue: 4
Pages: 489-503
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Publication
29887864 | J:284724
 
First Author: Qu W
Year: 2018
Journal: Front Immunol
Title: Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis.
Volume: 9
Pages: 1121
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Publication
34755090 | J:319462
First Author: Das M
Year: 2021
Journal: iScience
Title: Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models.
Volume: 24
Issue: 11
Pages: 103245
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Publication
31257031 | J:283590
First Author: Jaitin DA
Year: 2019
Journal: Cell
Title: Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.
Volume: 178
Issue: 3
Pages: 686-698.e14
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Publication
29794134 | J:270386
First Author: Sudom A
Year: 2018
Journal: J Biol Chem
Title: Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Volume: 293
Issue: 32
Pages: 12634-12646
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Publication
24893973 | J:241976
 
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
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Publication
28680398 | J:255985
 
First Author: Zhong L
Year: 2017
Journal: Front Aging Neurosci
Title: TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.
Volume: 9
Pages: 204
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Publication
29040522 | J:243746
     
First Author: Kang SS
Year: 2017
Journal: Hum Mol Genet
Title: Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
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Publication
26976047 | J:284612
First Author: Saber M
Year: 2017
Journal: J Neurotrauma
Title: Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury.
Volume: 34
Issue: 2
Pages: 423-435
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Publication
26374899 | J:236660
First Author: Atagi Y
Year: 2015
Journal: J Biol Chem
Title: Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Volume: 290
Issue: 43
Pages: 26043-50
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Publication
29599291 | J:267273
First Author: Cheng Q
Year: 2018
Journal: J Biol Chem
Title: TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Volume: 293
Issue: 32
Pages: 12620-12633
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Publication
27143430 | J:235008
 
First Author: Zheng H
Year: 2016
Journal: Neurobiol Aging
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Volume: 42
Pages: 132-41
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Publication
25716838 | J:219850
First Author: Kawabori M
Year: 2015
Journal: J Neurosci
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
Volume: 35
Issue: 8
Pages: 3384-96
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Publication
33823153 | J:308299
 
First Author: Vilalta A
Year: 2021
Journal: J Biol Chem
Title: Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Volume: 296
Pages: 100631
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Publication
37054900 | J:340895
 
First Author: Duwat C
Year: 2023
Journal: Neurobiol Dis
Title: Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology.
Volume: 181
Pages: 106116
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Publication
33556472 | J:311382
 
First Author: Ye H
Year: 2021
Journal: Mol Cell Endocrinol
Title: Triggering receptor expressed on myeloid Cells-2 (TREM2) inhibits steroidogenesis in adrenocortical cell by macrophage-derived exosomes in lipopolysaccharide-induced septic shock.
Volume: 525
Pages: 111178
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Publication
30341064 | J:277861
 
First Author: Lessard CB
Year: 2018
Journal: EMBO Mol Med
Title: High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Volume: 10
Issue: 11
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Publication
24368090 | J:213889
First Author: Jiang T
Year: 2014
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.
Volume: 35
Issue: 6
Pages: 1243-51
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Publication
25114293 | J:230233
First Author: Park M
Year: 2015
Journal: Diabetes
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity.
Volume: 64
Issue: 1
Pages: 117-27
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Publication
36868226 | J:347460
First Author: Bancaro N
Year: 2023
Journal: Cancer Cell
Title: Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer.
Volume: 41
Issue: 3
Pages: 602-619.e11
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Publication
36368315 | J:336013
First Author: Gratuze M
Year: 2023
Journal: Neuron
Title: TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
Volume: 111
Issue: 2
Pages: 202-219.e7
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Publication
18391000 | J:136148
First Author: Charles JF
Year: 2008
Journal: Infect Immun
Title: The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Volume: 76
Issue: 6
Pages: 2439-47
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Publication
28930663 | J:256695
First Author: Krasemann S
Year: 2017
Journal: Immunity
Title: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Volume: 47
Issue: 3
Pages: 566-581.e9
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Publication
34100905 | J:308485
 
First Author: Gratuze M
Year: 2021
Journal: J Exp Med
Title: Activated microglia mitigate Aβ-associated tau seeding and spreading.
Volume: 218
Issue: 8
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Publication
32613609 | J:304182
First Author: Rong Z
Year: 2020
Journal: FASEB J
Title: Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.
Volume: 34
Issue: 8
Pages: 10984-10997
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Publication
34851693 | J:321548
First Author: Sayed FA
Year: 2021
Journal: Sci Transl Med
Title: AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Volume: 13
Issue: 622
Pages: eabe3947
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Publication
33841415 | J:308249
 
First Author: Cheng B
Year: 2021
Journal: Front Immunol
Title: Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival.
Volume: 12
Pages: 633796
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Publication
38505612 | J:346378
First Author: Liang Y
Year: 2024
Journal: Theranostics
Title: Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages.
Volume: 14
Issue: 5
Pages: 2232-2245
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Publication
28189343 | J:243139
 
First Author: Belloli S
Year: 2017
Journal: Neurobiol Aging
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.
Volume: 53
Pages: 159-168
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Publication
30756214 | J:295238
First Author: Zhou J
Year: 2019
Journal: Neurochem Res
Title: Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.
Volume: 44
Issue: 5
Pages: 1138-1151
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Publication
29587871 | J:265880
First Author: Zhong L
Year: 2018
Journal: Mol Neurodegener
Title: Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Volume: 13
Issue: 1
Pages: 15
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Publication
36183964 | J:329984
 
First Author: Hoogland ICM
Year: 2022
Journal: Neurosci Lett
Title: Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli.
Volume: 790
Pages: 136894
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Publication
23301011 | J:195821
First Author: Sieber MW
Year: 2013
Journal: PLoS One
Title: Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.
Volume: 8
Issue: 1
Pages: e52982
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Publication
35575023 | J:326358
First Author: Essex AL
Year: 2022
Journal: J Bone Miner Res
Title: Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice.
Volume: 37
Issue: 7
Pages: 1366-1381
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Publication
35973424 | J:329206
First Author: Zhang P
Year: 2022
Journal: Cell Metab
Title: Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
Volume: 34
Issue: 9
Pages: 1359-1376.e7
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Publication
33097708 | J:296852
First Author: McQuade A
Year: 2020
Journal: Nat Commun
Title: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 5370
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Publication
33637522 | J:327683
 
First Author: Zarb Y
Year: 2021
Journal: Sci Adv
Title: Microglia control small vessel calcification via TREM2.
Volume: 7
Issue: 9
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Publication
34099706 | J:322192
First Author: Fitz NF
Year: 2021
Journal: Nat Commun
Title: Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 3416
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Publication
31091440 | J:288859
First Author: Anderson SR
Year: 2019
Journal: Cell Rep
Title: Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia.
Volume: 27
Issue: 7
Pages: 2002-2013.e5
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Publication
36389767 | J:332109
 
First Author: Katsumoto A
Year: 2022
Journal: Front Immunol
Title: Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy.
Volume: 13
Pages: 978423
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Publication
38347225 | J:346614
First Author: Yin T
Year: 2024
Journal: EMBO Rep
Title: Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias.
Volume: 25
Issue: 3
Pages: 1326-1360
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Publication
32544086 | J:299500
First Author: Gratuze M
Year: 2020
Journal: J Clin Invest
Title: Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Volume: 130
Issue: 9
Pages: 4954-4968
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Publication
27091843 | J:233314
First Author: Wang Y
Year: 2016
Journal: J Exp Med
Title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Volume: 213
Issue: 5
Pages: 667-75
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Publication
20421649 | J:161231
First Author: Koth LL
Year: 2010
Journal: J Immunol
Title: DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
Volume: 184
Issue: 11
Pages: 6522-8
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Publication
36803190 | J:337531
First Author: Tran KM
Year: 2023
Journal: Mol Neurodegener
Title: A Trem2(R47H) mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.
Volume: 18
Issue: 1
Pages: 12
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20484116 | J:185412
First Author: Peng Q
Year: 2010
Journal: Sci Signal
Title: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Volume: 3
Issue: 122
Pages: ra38
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16418779 | J:273549
First Author: Humphrey MB
Year: 2006
Journal: J Bone Miner Res
Title: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Volume: 21
Issue: 2
Pages: 237-45
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27798193 | J:236444
First Author: Kobayashi M
Year: 2016
Journal: J Neurosci
Title: TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain.
Volume: 36
Issue: 43
Pages: 11138-11150
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Publication
11241283 | J:68104
First Author: Daws MR
Year: 2001
Journal: Eur J Immunol
Title: Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
Volume: 31
Issue: 3
Pages: 783-91
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16482519 | J:110395
First Author: Floyd HS
Year: 2006
Journal: Mol Carcinog
Title: Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.
Volume: 45
Issue: 7
Pages: 506-17
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30013047 | J:267923
First Author: Mlodzianoski MJ
Year: 2018
Journal: Nat Methods
Title: Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Volume: 15
Issue: 8
Pages: 583-586
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25860078 | J:345343
First Author: Hommes TJ
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.
Volume: 53
Issue: 5
Pages: 647-55
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Publication
28602351 | J:324482
First Author: Keren-Shaul H
Year: 2017
Journal: Cell
Title: A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Volume: 169
Issue: 7
Pages: 1276-1290.e17
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29448957 | J:260587
First Author: Beckmann N
Year: 2018
Journal: Acta Neuropathol Commun
Title: Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.
Volume: 6
Issue: 1
Pages: 9
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Publication
33628208 | J:314043
 
First Author: Coelho I
Year: 2020
Journal: Front Immunol
Title: Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage.
Volume: 11
Pages: 616044
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31900229 | J:304588
First Author: Zhang J
Year: 2020
Journal: J Neuroinflammation
Title: TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus.
Volume: 17
Issue: 1
Pages: 2
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12847223 | J:210929
First Author: Daws MR
Year: 2003
Journal: J Immunol
Title: Pattern recognition by TREM-2: binding of anionic ligands.
Volume: 171
Issue: 2
Pages: 594-9
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Publication
19079182 | J:191922
First Author: Quan DN
Year: 2008
Journal: Mucosal Immunol
Title: TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells.
Volume: 1
Issue: 3
Pages: 229-38
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16675145 | J:110305
First Author: Prada I
Year: 2006
Journal: Neuroscience
Title: Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.
Volume: 140
Issue: 4
Pages: 1139-48
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Publication
17407101 | J:123559
First Author: Piccio L
Year: 2007
Journal: Eur J Immunol
Title: Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.
Volume: 37
Issue: 5
Pages: 1290-301
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19698700 | J:153535
First Author: Chang JH
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation.
Volume: 389
Issue: 1
Pages: 28-33
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Publication
23611998 | J:215288
First Author: Sun M
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.
Volume: 54
Issue: 5
Pages: 3451-62
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Publication
34878838 | J:320018
First Author: Wu Y
Year: 2021
Journal: Sci Adv
Title: TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection.
Volume: 7
Issue: 50
Pages: eabi6802
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24945405 | J:246764
First Author: Sharif O
Year: 2014
Journal: PLoS Pathog
Title: The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.
Volume: 10
Issue: 6
Pages: e1004167
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Publication
37286175 | J:337828
 
First Author: Wu K
Year: 2023
Journal: Brain Behav Immun
Title: The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
Volume: 112
Pages: 96-117
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19948717 | J:159944
First Author: Whittaker GC
Year: 2010
Journal: J Biol Chem
Title: The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Volume: 285
Issue: 5
Pages: 2976-85
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16887962 | J:138377
First Author: Hamerman JA
Year: 2006
Journal: J Immunol
Title: Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.
Volume: 177
Issue: 4
Pages: 2051-5
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Publication
22761415 | J:192976
First Author: Yoon SH
Year: 2012
Journal: J Biol Chem
Title: TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
Volume: 287
Issue: 35
Pages: 29620-6
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Publication
38302493 | J:344839
First Author: Sun R
Year: 2024
Journal: Nat Commun
Title: Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.
Volume: 15
Issue: 1
Pages: 966
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10799849 | J:64954
First Author: Bouchon A
Year: 2000
Journal: J Immunol
Title: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
Volume: 164
Issue: 10
Pages: 4991-5
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18957693 | J:258167
First Author: Helming L
Year: 2008
Journal: Sci Signal
Title: Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
Volume: 1
Issue: 43
Pages: ra11
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19155473 | J:144335
First Author: Hemmi H
Year: 2009
Journal: J Immunol
Title: A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.
Volume: 182
Issue: 3
Pages: 1278-86
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Publication
21956652 | J:179836
First Author: Ito H
Year: 2012
Journal: Eur J Immunol
Title: TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells.
Volume: 42
Issue: 1
Pages: 176-85
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16951310 | J:138057
First Author: Turnbull IR
Year: 2006
Journal: J Immunol
Title: Cutting edge: TREM-2 attenuates macrophage activation.
Volume: 177
Issue: 6
Pages: 3520-4
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Publication
34644146 | J:324411
First Author: Xiang X
Year: 2021
Journal: Sci Transl Med
Title: Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Volume: 13
Issue: 615
Pages: eabe5640
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Publication
16046394 | J:132544
First Author: Kim Y
Year: 2005
Journal: J Biol Chem
Title: Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
Volume: 280
Issue: 38
Pages: 32905-13
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Publication
36280798 | J:337595
First Author: Kaya T
Year: 2022
Journal: Nat Neurosci
Title: CD8(+) T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging.
Volume: 25
Issue: 11
Pages: 1446-1457
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Publication
33172468 | J:341531
First Author: Preuss C
Year: 2020
Journal: Mol Neurodegener
Title: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.
Volume: 15
Issue: 1
Pages: 67
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Publication
37016304 | J:341529
First Author: Pandey RS
Year: 2023
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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