Type |
Details |
Score |
Publication |
First Author: |
Weaver D |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. |
Volume: |
54 |
Issue: |
5 |
Pages: |
870-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Lactate metabolism is essential in early-onset mitochondrial myopathy. |
Volume: |
9 |
Issue: |
1 |
Pages: |
eadd3216 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. |
Volume: |
12 |
Issue: |
1 |
Pages: |
14883 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papanicolaou KN |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1309-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Che Y |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. |
Volume: |
42 |
Issue: |
1 |
Pages: |
112011 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sood A |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. |
Volume: |
111 |
Issue: |
45 |
Pages: |
16017-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. |
Volume: |
61 |
Issue: |
1 |
Pages: |
111-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song M |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. |
Volume: |
26 |
Issue: |
6 |
Pages: |
872-883.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwek XY |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Role of cardiac mitofusins in cardiac conduction following simulated ischemia-reperfusion. |
Volume: |
12 |
Issue: |
1 |
Pages: |
21049 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brooks C |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. |
Volume: |
300 |
Issue: |
3 |
Pages: |
C447-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horn A |
Year: |
2020 |
Journal: |
J Cell Biol |
Title: |
Mitochondrial fragmentation enables localized signaling required for cell repair. |
Volume: |
219 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
GÓ§bel J |
Year: |
2020 |
Journal: |
Cell Metab |
Title: |
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. |
Volume: |
31 |
Issue: |
4 |
Pages: |
791-808.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wani GA |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. |
Volume: |
38 |
Issue: |
7 |
Pages: |
110370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motori E |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction. |
Volume: |
6 |
Issue: |
35 |
Pages: |
eaba8271 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biel TG |
Year: |
2016 |
Journal: |
Cell Death Differ |
Title: |
Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner. |
Volume: |
23 |
Issue: |
2 |
Pages: |
279-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song Z |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. |
Volume: |
20 |
Issue: |
15 |
Pages: |
3525-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tondera D |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
SLP-2 is required for stress-induced mitochondrial hyperfusion. |
Volume: |
28 |
Issue: |
11 |
Pages: |
1589-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen H |
Year: |
2010 |
Journal: |
Cell |
Title: |
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. |
Volume: |
141 |
Issue: |
2 |
Pages: |
280-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song M |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. |
Volume: |
21 |
Issue: |
2 |
Pages: |
273-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra P |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
Mitochondrial Dynamics is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1033-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. |
Volume: |
27 |
Issue: |
22 |
Pages: |
3881-3900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dubinin MV |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis. |
Volume: |
22 |
Issue: |
18 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang KS |
Year: |
2005 |
Journal: |
Mamm Genome |
Title: |
Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. |
Volume: |
16 |
Issue: |
5 |
Pages: |
332-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichinohe T |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. |
Volume: |
110 |
Issue: |
44 |
Pages: |
17963-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan KQ |
Year: |
2019 |
Journal: |
Cell |
Title: |
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior. |
Volume: |
179 |
Issue: |
4 |
Pages: |
864-879.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kasahara A |
Year: |
2013 |
Journal: |
Science |
Title: |
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. |
Volume: |
342 |
Issue: |
6159 |
Pages: |
734-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whelan RS |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Bax regulates primary necrosis through mitochondrial dynamics. |
Volume: |
109 |
Issue: |
17 |
Pages: |
6566-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
CorrĂŞa da Silva F |
Year: |
2019 |
Journal: |
Free Radic Biol Med |
Title: |
Ghrelin effects on mitochondrial fitness modulates macrophage function. |
Volume: |
145 |
|
Pages: |
61-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waxman AB |
Year: |
2009 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. |
Volume: |
41 |
Issue: |
4 |
Pages: |
385-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishihara N |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. |
Volume: |
11 |
Issue: |
8 |
Pages: |
958-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fame RM |
Year: |
2019 |
Journal: |
Development |
Title: |
A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. |
Volume: |
146 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Moriya M |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. |
Volume: |
24 |
Issue: |
25 |
Pages: |
7349-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marta C |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. |
Volume: |
12 |
Issue: |
1 |
Pages: |
16152 |
|
•
•
•
•
•
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Publication |
First Author: |
Suh J |
Year: |
2023 |
Journal: |
Cell Metab |
Title: |
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. |
Volume: |
35 |
Issue: |
2 |
Pages: |
345-360.e7 |
|
•
•
•
•
•
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Publication |
First Author: |
Mirra S |
Year: |
2021 |
Journal: |
Neurobiol Dis |
Title: |
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina. |
Volume: |
156 |
|
Pages: |
105405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng TG |
Year: |
2023 |
Journal: |
Adv Sci (Weinh) |
Title: |
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. |
Volume: |
10 |
Issue: |
27 |
Pages: |
e2301940 |
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•
•
•
•
•
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Publication |
First Author: |
Shen T |
Year: |
2024 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. |
Volume: |
710 |
|
Pages: |
149883 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papanicolaou KN |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. |
Volume: |
111 |
Issue: |
8 |
Pages: |
1012-26 |
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•
•
•
•
•
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Publication |
First Author: |
GĂłmez-Del Arco P |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. |
Volume: |
23 |
Issue: |
5 |
Pages: |
881-92 |
|
•
•
•
•
•
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Publication |
First Author: |
Menendez-Montes I |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. |
Volume: |
39 |
Issue: |
6 |
Pages: |
724-739 |
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•
•
•
•
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Publication |
First Author: |
Kalsotra A |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. |
Volume: |
105 |
Issue: |
51 |
Pages: |
20333-8 |
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Publication |
First Author: |
Kiyama T |
Year: |
2018 |
Journal: |
Mol Neurodegener |
Title: |
Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. |
Volume: |
13 |
Issue: |
1 |
Pages: |
56 |
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•
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Publication |
First Author: |
Salazar-Petres E |
Year: |
2022 |
Journal: |
Biol Reprod |
Title: |
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in miceâ . |
Volume: |
106 |
Issue: |
6 |
Pages: |
1292-1311 |
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Publication |
First Author: |
Li J |
Year: |
2018 |
Journal: |
Database (Oxford) |
Title: |
CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. |
Volume: |
2018 |
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•
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Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
1 |
Pages: |
112-23 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
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Title: |
RIKEN Data Curation in Mouse Genome Informatics |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
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Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
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First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
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130-136 |
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GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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First Author: |
Okazaki Y |
Year: |
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Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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The Gene Ontology Consortium |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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PLoS Biol |
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Mouse Genome Informatics Scientific Curators |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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First Author: |
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Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
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Database Release |
Title: |
Entrez Gene Load |
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Mouse Genome Informatics Group |
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Database Procedure |
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Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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First Author: |
Mouse Genome Informatics Scientific Curators |
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2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Mouse Genome Informatics |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
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Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Martorell-Riera A |
Year: |
2014 |
Journal: |
EMBO J |
Title: |
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. |
Volume: |
33 |
Issue: |
20 |
Pages: |
2388-407 |
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Publication |
First Author: |
Sorianello E |
Year: |
2012 |
Journal: |
Cardiovasc Res |
Title: |
The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells. |
Volume: |
94 |
Issue: |
1 |
Pages: |
38-47 |
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Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Pleasure |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change |
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DO Term |
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Allele |
Name: |
transgene insertion L87, University of Geneva Faculty of Medicine |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nes-cre)1Kln/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Tg(Eno2-MFN2*R94Q)L87Ugfm/Tg(Eno2-MFN2*R94Q)L87Ugfm |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Interaction Experiment |
Description: |
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. |
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Interaction Experiment |
Description: |
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
757
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Fragment?: |
false |
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Allele |
Name: |
transgene insertion L51, University of Geneva Faculty of Medicine |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
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Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
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Allele |
Name: |
transgene insertion 1, David C Chan |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence, Reporter |
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Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
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Genotype |
Symbol: |
Tg(Eno2-MFN2*R94Q)L51Ugfm/? |
Background: |
involves: C57BL/6 * C57BL/6J * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Tg(Eno2-MFN2*R94Q)L51Ugfm/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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DO Term |
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Genotype |
Symbol: |
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Publication |
First Author: |
McLelland GL |
Year: |
2018 |
Journal: |
Elife |
Title: |
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. |
Volume: |
7 |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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