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Search results 3501 to 3600 out of 4694 for Notch1

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Type Details Score
HT Experiment
GSE110614 | Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
20960513 | J:168858
First Author: Kitamoto T
Year: 2010
Journal: Stem Cells
Title: Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration.
Volume: 28
Issue: 12
Pages: 2205-16
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Protein
E9Q6E8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q69Z97
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
F6UY95
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
Q8BMG4
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q5U409
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q6ZPH8
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
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Protein
Q3TZA9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
Q810L0
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
E9Q7L5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Publication
12050117 | -
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
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Protein Domain
IPR000800 | Notch_dom
Type: Domain
Description: The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator []. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [, ]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues []. The biochemical characterisation of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the firstand fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+,which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+binding, and thereby contribute to the native fold.
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Protein Domain
IPR046370 | MAML_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR046369 | MAML1-3
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR019082 | Mastermind-like_N
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR035993 | Notch-like_dom_sf
Type: Homologous_superfamily
Description: The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator []. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [, ]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues []. The biochemical characterisation of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the firstand fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+binding, and thereby contribute to the native fold.
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Publication
18927153 | J:143587
First Author: Tang H
Year: 2008
Journal: Development
Title: Notch signaling maintains Leydig progenitor cells in the mouse testis.
Volume: 135
Issue: 22
Pages: 3745-53
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Publication
29780306 | J:264391
 
First Author: McGovern MM
Year: 2018
Journal: Front Cell Neurosci
Title: Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells.
Volume: 12
Pages: 120
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Publication
28215940 | J:241013
First Author: Grassmeyer J
Year: 2017
Journal: Dev Biol
Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Volume: 424
Issue: 1
Pages: 77-89
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Publication
12753744 | J:83476
First Author: Saito T
Year: 2003
Journal: Immunity
Title: Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Volume: 18
Issue: 5
Pages: 675-85
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Publication
18676808 | J:139492
First Author: Jeon HM
Year: 2008
Journal: Genes Dev
Title: Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Volume: 22
Issue: 15
Pages: 2028-33
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Publication
8573724 | J:29516
First Author: Mallo M
Year: 1995
Journal: Dev Dyn
Title: Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.
Volume: 204
Issue: 3
Pages: 338-47
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Publication
21478879 | J:172130
First Author: Rathinam C
Year: 2011
Journal: Nat Immunol
Title: The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.
Volume: 12
Issue: 5
Pages: 399-407
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Publication
15288263 | J:92119
First Author: Lefort K
Year: 2004
Journal: Semin Cancer Biol
Title: Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.
Volume: 14
Issue: 5
Pages: 374-86
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Publication
16612405 | J:114914
First Author: Grabher C
Year: 2006
Journal: Nat Rev Cancer
Title: Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
Volume: 6
Issue: 5
Pages: 347-59
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Publication
25564622 | J:238903
First Author: Mori M
Year: 2015
Journal: Development
Title: Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Volume: 142
Issue: 2
Pages: 258-67
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Protein Coding Gene
MGI:1276116 | Ep300
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B2RWS6
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
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Publication
23520387 | J:195278
First Author: Yanger K
Year: 2013
Journal: Genes Dev
Title: Robust cellular reprogramming occurs spontaneously during liver regeneration.
Volume: 27
Issue: 7
Pages: 719-24
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Publication
30105024 | J:278727
 
First Author: Lin Y
Year: 2018
Journal: Front Immunol
Title: Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression.
Volume: 9
Pages: 1744
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Publication
25429074 | J:230688
First Author: Nakamura M
Year: 2015
Journal: J Immunol
Title: A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Volume: 194
Issue: 1
Pages: 243-51
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Publication
22991339 | J:233259
First Author: Chen S
Year: 2013
Journal: J Bone Miner Res
Title: Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9.
Volume: 28
Issue: 3
Pages: 649-59
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Strain
MGI:3044664 | B6.Cg-Tg(Nes-cre)1Kln Tg(ACTB-NOTCH1)1Shn
Attribute String: congenic, mutant stock, transgenic
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Publication
23748444 | J:204568
First Author: Maddaluno L
Year: 2013
Journal: Nature
Title: EndMT contributes to the onset and progression of cerebral cavernous malformations.
Volume: 498
Issue: 7455
Pages: 492-6
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Publication
20299358 | J:185844
First Author: Fujimura S
Year: 2010
Journal: J Am Soc Nephrol
Title: Notch2 activation in the embryonic kidney depletes nephron progenitors.
Volume: 21
Issue: 5
Pages: 803-10
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Allele
Gt(ROSA)26Sor<tm8(CAG-EYFP*,-mCherry*,-EGFP*,-Maml1*,-mCerulean*,-Notch1*)Ben> | MGI:6761439
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Rui Benedito
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Allele
Gt(ROSA)26Sor<tm9(CAG-mEYFP*,-tdTomato*,-Notch1*,-mKate2*,-Rbpj*)Ben> | MGI:6761546
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Rui Benedito
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Allele
Notch4<tm1Grid> | MGI:1929139
 
Name: notch 4; targeted mutation 1, Tom Gridley
Allele Type: Targeted
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Nes-cre)1Kln/? Tg(ACTB-NOTCH1)1Shn/?
Background: B6.Cg-Tg(Nes-cre)1Kln Tg(ACTB-NOTCH1)1Shn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Actb-NOTCH1)2Shn/? Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ACTB-NOTCH1)1Shn/? Tg(Syn1-cre)671Jxm/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ACTB-NOTCH1)1Shn/? Tg(Nes-cre/Esr1*)4Ynj/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp1/Mesp1<+> Rbpj/Rbpj Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp1/Mesp1<+> Pofut1/Pofut1 Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: C3H * C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras Tg(Pdx1-cre/Esr1*)35.10Dam/?
Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras Tg(Cela1-cre/ERT)1Dam/?
Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Neurod1-cre)1Able/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Neurog3-cre)C1Able/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ndor1/?
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alb/Alb<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2 Tg(Pax3-cre)1Joe/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Tg(Pax3-cre)1Joe/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Rbpj/Rbpj Tg(Col1a1-cre)1Kry/?
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adam10/Adam10 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Six3-cre)69Frty/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1
Background: involves: 129X1/SvJ * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
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Publication
8139658 | -
First Author: Tax FE
Year: 1994
Journal: Nature
Title: Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.
Volume: 368
Issue: 6467
Pages: 150-4
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Protein
Q6P1E1
Organism: Mus musculus/domesticus
Length: 1072  
Fragment?: false
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Publication
15146182 | J:90630
First Author: Hozumi K
Year: 2004
Journal: Nat Immunol
Title: Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.
Volume: 5
Issue: 6
Pages: 638-44
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Publication
14567914 | J:86140
First Author: Hu QD
Year: 2003
Journal: Cell
Title: F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Volume: 115
Issue: 2
Pages: 163-75
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Publication
20622884 | J:162388
First Author: Hodson DJ
Year: 2010
Journal: Nat Immunol
Title: Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.
Volume: 11
Issue: 8
Pages: 717-24
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Publication
32555153 | J:293238
First Author: Choi HY
Year: 2020
Journal: Nat Commun
Title: p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs.
Volume: 11
Issue: 1
Pages: 3084
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Publication
29311361 | J:274294
First Author: Kostrzewski T
Year: 2018
Journal: J Immunol
Title: Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Volume: 200
Issue: 4
Pages: 1370-1381
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Publication
27612641 | J:259932
First Author: Ettersperger J
Year: 2016
Journal: Immunity
Title: Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease.
Volume: 45
Issue: 3
Pages: 610-625
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Publication
36759621 | J:340160
First Author: Lu H
Year: 2023
Journal: Nat Commun
Title: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
Volume: 14
Issue: 1
Pages: 731
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Publication
23287858 | J:194772
First Author: García-Ojeda ME
Year: 2013
Journal: Blood
Title: GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice.
Volume: 121
Issue: 10
Pages: 1749-59
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Publication
21622646 | J:174869
First Author: Hauer J
Year: 2011
Journal: Blood
Title: Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.
Volume: 118
Issue: 3
Pages: 544-53
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Publication
27346341 | J:238522
First Author: Pasut A
Year: 2016
Journal: Cell Rep
Title: Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation.
Volume: 16
Issue: 2
Pages: 333-43
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Publication
15353549 | J:92520
First Author: Vanderluit JL
Year: 2004
Journal: J Cell Biol
Title: p107 regulates neural precursor cells in the mammalian brain.
Volume: 166
Issue: 6
Pages: 853-63
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Publication
21898766 | J:187874
First Author: Berquam-Vrieze KE
Year: 2012
Journal: Genesis
Title: Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.
Volume: 50
Issue: 2
Pages: 112-8
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Publication
24949995 | J:270134
First Author: Yoshizaki K
Year: 2014
Journal: PLoS One
Title: Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.
Volume: 9
Issue: 6
Pages: e99991
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Publication
19050235 | J:142081
First Author: Fiorini E
Year: 2008
Journal: J Immunol
Title: Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.
Volume: 181
Issue: 12
Pages: 8199-203
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Publication
18297084 | J:133658
First Author: Engin F
Year: 2008
Journal: Nat Med
Title: Dimorphic effects of Notch signaling in bone homeostasis.
Volume: 14
Issue: 3
Pages: 299-305
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Publication
12649319 | J:82745
First Author: Schmid RS
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex.
Volume: 100
Issue: 7
Pages: 4251-6
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