Tubulin polyglutamylation plays an important role for several MT-related processes, such as motility of cilia and flagella, stability of centrosomes, and neurite outgrowth. Glutamylation is catalyzed by polyglutamylases, also called as tubulin tyrosine ligase-like (TTLL) enzymes[].TTLL1 is a catalytic subunit of the neuronal tubulin polyglutamylase complex. It modifies alpha and beta tubulin, generating side chains of glutamate on the γ-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha and beta tubulin [].
