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Search results 1 to 100 out of 379 for Shc1

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Type Details Score
Gene
6464 | SHC1
Type: gene
Organism: human
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Gene
490439 | SHC1
Type: gene
Organism: dog, domestic
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Gene
507196 | SHC1
Type: gene
Organism: cattle
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Gene
395934 | SHC1
Type: gene
Organism: chicken
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Gene
323818 | shc1
Type: gene
Organism: zebrafish
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Gene
718982 | SHC1
Type: gene
Organism: macaque, rhesus
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Gene
100492349 | shc1
Type: gene
Organism: frog, western clawed
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Gene
116406911 | shc1
Type: gene
Organism: frog, western clawed
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Gene
85385 | Shc1
Type: gene
Organism: rat
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Gene
457351 | SHC1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:98296 | Shc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28276425 | J:244404
 
First Author: Ahn R
Year: 2017
Journal: Nat Commun
Title: The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
Volume: 8
Pages: 14638
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Gene
101928120 | PYGO2-AS1
Type: gene
Organism: human
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Publication
16982683 | J:118108
First Author: Trampont P
Year: 2006
Journal: Mol Cell Biol
Title: ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Volume: 26
Issue: 23
Pages: 9035-44
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Publication
16870734 | J:111058
First Author: McFarland KN
Year: 2006
Journal: J Neurosci
Title: Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
Volume: 26
Issue: 30
Pages: 7885-97
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Publication
23846654 | J:204749
First Author: Zheng Y
Year: 2013
Journal: Nature
Title: Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
Volume: 499
Issue: 7457
Pages: 166-71
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Publication
22286768 | J:191777
First Author: Ursini-Siegel J
Year: 2012
Journal: Oncogene
Title: The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
Volume: 31
Issue: 48
Pages: 5038-44
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Publication
23695548 | J:199117
First Author: Ahn R
Year: 2013
Journal: Cancer Res
Title: The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Volume: 73
Issue: 14
Pages: 4521-32
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Publication
24550542 | J:259722
First Author: Soliman MA
Year: 2014
Journal: Sci Signal
Title: The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.
Volume: 7
Issue: 313
Pages: ra17
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Publication
29540796 | J:263705
First Author: Abou-Jaoude A
Year: 2018
Journal: Sci Rep
Title: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.
Volume: 8
Issue: 1
Pages: 4501
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Publication
30109811 | J:309095
First Author: Onnis A
Year: 2018
Journal: Autophagy
Title: The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Volume: 14
Issue: 12
Pages: 2117-2138
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Publication
20226234 | J:161488
First Author: Ponti G
Year: 2010
Journal: Neuroscience
Title: Neural-specific inactivation of ShcA functions results in anatomical disorganization of subventricular zone neural stem cell niche in the adult brain.
Volume: 168
Issue: 1
Pages: 314-22
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Publication
12101399 | J:78180
First Author: Zhang L
Year: 2002
Journal: Nat Immunol
Title: A nonredundant role for the adapter protein Shc in thymic T cell development.
Volume: 3
Issue: 8
Pages: 749-55
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Publication
1623525 | J:17164
First Author: Pelicci G
Year: 1992
Journal: Cell
Title: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Volume: 70
Issue: 1
Pages: 93-104
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Publication
15716419 | J:98227
First Author: Miyamoto Y
Year: 2005
Journal: J Neurosci
Title: Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.
Volume: 25
Issue: 7
Pages: 1826-35
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Publication
25488665 | J:217881
First Author: Mlih M
Year: 2015
Journal: J Biol Chem
Title: The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Volume: 290
Issue: 4
Pages: 2419-30
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Publication
25691660 | J:224420
First Author: Trampont PC
Year: 2015
Journal: Mol Cell Biol
Title: ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
Volume: 35
Issue: 8
Pages: 1462-76
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Publication
19828641 | J:156802
First Author: Giles AJ
Year: 2009
Journal: J Immunol
Title: The adaptor protein Shc plays a key role during early B cell development.
Volume: 183
Issue: 9
Pages: 5468-76
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Publication
25153088 | J:212898
First Author: Buckley MW
Year: 2014
Journal: PLoS One
Title: Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Volume: 9
Issue: 8
Pages: e105576
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Protein Coding Gene
MGP_CAROLIEiJ_G0025210 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027154 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026654 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026153 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12571362 | J:81977
First Author: Napoli C
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Volume: 100
Issue: 4
Pages: 2112-6
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Publication
20924104 | J:165565
First Author: Ursini-Siegel J
Year: 2010
Journal: Cancer Res
Title: Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Volume: 70
Issue: 20
Pages: 7776-87
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Publication
29930100 | J:265552
First Author: Im YK
Year: 2018
Journal: Cancer Res
Title: Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.
Volume: 78
Issue: 17
Pages: 4826-4838
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Publication
22096252 | J:181797
First Author: Sweet DT
Year: 2012
Journal: Blood
Title: The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.
Volume: 119
Issue: 8
Pages: 1946-55
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Publication
23661718 | J:213409
First Author: Sweet DT
Year: 2013
Journal: Circ Res
Title: Endothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-κ-light-chain-enhancer of activated B-cell pathways.
Volume: 113
Issue: 1
Pages: 32-39
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Publication
10580504 | J:58535
First Author: Migliaccio E
Year: 1999
Journal: Nature
Title: The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Volume: 402
Issue: 6759
Pages: 309-13
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Publication
25810038 | J:220826
First Author: Natalicchio A
Year: 2015
Journal: Diabetologia
Title: The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.
Volume: 58
Issue: 6
Pages: 1260-71
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Publication
19889727 | J:158867
First Author: Naldini A
Year: 2010
Journal: J Leukoc Biol
Title: The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells.
Volume: 87
Issue: 3
Pages: 365-9
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Publication
18334675 | J:135994
First Author: Finetti F
Year: 2008
Journal: Blood
Title: The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
Volume: 111
Issue: 10
Pages: 5017-27
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Publication
28740219 | J:253031
First Author: Granatiero V
Year: 2017
Journal: Sci Rep
Title: Role of p66shc in skeletal muscle function.
Volume: 7
Issue: 1
Pages: 6283
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Publication
20061561 | J:160277
First Author: Capitani N
Year: 2010
Journal: Blood
Title: Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia.
Volume: 115
Issue: 18
Pages: 3726-36
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Publication
30819907 | J:293864
First Author: Patrussi L
Year: 2019
Journal: Haematologica
Title: p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape.
Volume: 104
Issue: 10
Pages: 2040-2052
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Publication
15173034 | J:102204
First Author: Zaccagnini G
Year: 2004
Journal: Circulation
Title: p66ShcA modulates tissue response to hindlimb ischemia.
Volume: 109
Issue: 23
Pages: 2917-23
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Publication
24078705 | J:209538
First Author: Masi G
Year: 2014
Journal: J Leukoc Biol
Title: p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics.
Volume: 95
Issue: 2
Pages: 285-92
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Publication
21430228 | J:172861
First Author: Ulivieri C
Year: 2011
Journal: J Immunol
Title: p66Shc is a negative regulator of FcεRI-dependent signaling in mast cells.
Volume: 186
Issue: 9
Pages: 5095-106
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Publication
25880638 | J:233488
First Author: Hagopian K
Year: 2015
Journal: PLoS One
Title: Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins.
Volume: 10
Issue: 4
Pages: e0124204
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Publication
16731826 | J:111881
First Author: Menini S
Year: 2006
Journal: Diabetes
Title: Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.
Volume: 55
Issue: 6
Pages: 1642-50
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Publication
22573912 | J:187462
First Author: Gong J
Year: 2012
Journal: FASEB J
Title: Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.
Volume: 26
Issue: 8
Pages: 3537-49
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Publication
17726026 | J:126839
First Author: Zaccagnini G
Year: 2007
Journal: J Biol Chem
Title: p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.
Volume: 282
Issue: 43
Pages: 31453-9
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Publication
16763167 | J:123667
First Author: Rota M
Year: 2006
Journal: Circ Res
Title: Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Volume: 99
Issue: 1
Pages: 42-52
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Publication
25257068 | J:215532
First Author: Tomilov A
Year: 2014
Journal: Aging Cell
Title: Shc depletion stimulates brown fat activity in vivo and in vitro.
Volume: 13
Issue: 6
Pages: 1049-58
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Publication
38389706 | J:345583
 
First Author: Lopresti L
Year: 2024
Journal: Front Cell Dev Biol
Title: p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation.
Volume: 12
Pages: 1297116
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Publication
20085805 | J:164150
First Author: Berry A
Year: 2010
Journal: Exp Gerontol
Title: Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.
Volume: 45
Issue: 5
Pages: 343-50
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Publication
18065182 | J:132508
First Author: Berry A
Year: 2008
Journal: Exp Gerontol
Title: Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Volume: 43
Issue: 3
Pages: 200-8
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Publication
10797480 | J:61892
First Author: Lithgow GJ
Year: 2000
Journal: Bioessays
Title: The real Dorian Gray mouse.
Volume: 22
Issue: 5
Pages: 410-3
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Publication
21040401 | J:214936
First Author: Tomilov AA
Year: 2011
Journal: Aging Cell
Title: The Shc locus regulates insulin signaling and adiposity in mammals.
Volume: 10
Issue: 1
Pages: 55-65
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Publication
25790295 | J:229198
First Author: Lunghi B
Year: 2015
Journal: PLoS One
Title: Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
Volume: 10
Issue: 3
Pages: e0119797
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Publication
29466053 | J:271723
First Author: Ciciliot S
Year: 2018
Journal: FASEB J
Title: Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.
Volume: 32
Issue: 7
Pages: 4004-4015
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Publication
23033271 | J:190938
First Author: Capitani N
Year: 2012
Journal: Blood
Title: S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis.
Volume: 120
Issue: 22
Pages: 4391-9
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Publication
15998704 | J:114367
First Author: Graiani G
Year: 2005
Journal: Hypertension
Title: Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Volume: 46
Issue: 2
Pages: 433-40
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Publication
19362067 | J:153487
First Author: Carpi A
Year: 2009
Journal: Biochim Biophys Acta
Title: The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury.
Volume: 1787
Issue: 7
Pages: 774-80
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Publication
21527937 | J:203100
First Author: Magenta A
Year: 2011
Journal: Cell Death Differ
Title: miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition.
Volume: 18
Issue: 10
Pages: 1628-39
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Publication
16809014 | J:123169
First Author: Berry A
Year: 2007
Journal: Exp Gerontol
Title: Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Volume: 42
Issue: 1-2
Pages: 37-45
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Publication
18490896 | J:137098
First Author: Koch OR
Year: 2008
Journal: Lab Invest
Title: Role of the life span determinant P66(shcA) in ethanol-induced liver damage.
Volume: 88
Issue: 7
Pages: 750-60
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Publication
20566667 | J:169633
First Author: Fadini GP
Year: 2010
Journal: Diabetes
Title: The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Volume: 59
Issue: 9
Pages: 2306-14
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Publication
23144971 | J:195591
First Author: Stern JH
Year: 2012
Journal: PLoS One
Title: The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice.
Volume: 7
Issue: 11
Pages: e48790
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Publication
17360381 | J:120110
First Author: Camici GG
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.
Volume: 104
Issue: 12
Pages: 5217-22
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Publication
36827872 | J:335037
 
First Author: Huang C
Year: 2023
Journal: J Mol Cell Cardiol
Title: The longevity protein p66(Shc) is required for neonatal heart regeneration.
Volume: 177
Pages: 21-27
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Publication
29326436 | J:261034
First Author: Patrussi L
Year: 2018
Journal: Oncogene
Title: p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.
Volume: 37
Issue: 11
Pages: 1534-1550
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Publication
21828072 | J:176680
First Author: Pesaresi MG
Year: 2011
Journal: Hum Mol Genet
Title: Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation.
Volume: 20
Issue: 21
Pages: 4196-208
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Publication
26968134 | J:233002
First Author: Giorgio M
Year: 2016
Journal: Aging Cell
Title: P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.
Volume: 15
Issue: 3
Pages: 446-54
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Publication
21993884 | J:180074
First Author: Salhan D
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.
Volume: 302
Issue: 1
Pages: F129-40
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Publication
18413607 | J:248220
First Author: Gertz M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
Volume: 105
Issue: 15
Pages: 5705-9
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Publication
9049300 | J:38655
First Author: Migliaccio E
Year: 1997
Journal: EMBO J
Title: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Volume: 16
Issue: 4
Pages: 706-16
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Publication
9346957 | J:43710
First Author: Okada S
Year: 1997
Journal: J Biol Chem
Title: The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
Volume: 272
Issue: 44
Pages: 28042-9
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Publication
16520382 | J:107918
First Author: Khanday FA
Year: 2006
Journal: J Cell Biol
Title: Sos-mediated activation of rac1 by p66shc.
Volume: 172
Issue: 6
Pages: 817-22
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Publication
8887653 | J:113674
First Author: Borg JP
Year: 1996
Journal: Mol Cell Biol
Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Volume: 16
Issue: 11
Pages: 6229-41
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Publication
18606845 | J:138196
First Author: Liu Y
Year: 2008
Journal: J Cell Biol
Title: Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.
Volume: 182
Issue: 1
Pages: 185-96
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Publication
17431427 | J:139292
First Author: Kasuno K
Year: 2007
Journal: Cell Death Differ
Title: Antagonism of p66shc by melanoma inhibitory activity.
Volume: 14
Issue: 8
Pages: 1414-21
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Publication
19327338 | J:151016
First Author: Lebiedzinska M
Year: 2009
Journal: Arch Biochem Biophys
Title: Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
Volume: 486
Issue: 1
Pages: 73-80
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Publication
19386228 | J:154261
First Author: Papadimou E
Year: 2009
Journal: Mol Cell Neurosci
Title: p66(ShcA) adaptor molecule accelerates ES cell neural induction.
Volume: 41
Issue: 1
Pages: 74-84
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Publication
19696221 | J:155165
First Author: Kumar A
Year: 2009
Journal: FASEB J
Title: Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.
Volume: 23
Issue: 12
Pages: 4344-52
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