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Search results 301 to 400 out of 408 for Ptprz1

0.048s
Type Details Score
GXD Expression
Probe: MGI:7423852
Assay Type: RNA in situ
Annotation Date: 2023-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7424898
Age: embryonic day 11.5
Image: S6 - E11.5
Note: The mucosal OECs show expression.
Specimen Label: S6 - E11.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:7423852
Assay Type: RNA in situ
Annotation Date: 2023-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7424898
Age: embryonic day 13.0
Image: S6 - E13 - D2
Note: The mucosal OECs show expression.
Specimen Label: S6 - E13 - D2
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4365775
Assay Type: RNA in situ
Annotation Date: 2009-10-29
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689426
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:4365779
Age: embryonic day 20.0
Image: 7A
Note: High level of expression in ventricular and subventricular zones of the brain.
Specimen Label: 7A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4365775
Assay Type: RNA in situ
Annotation Date: 2009-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3548928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4365779
Age: postnatal adult
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5001049
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5541606
Age: embryonic day 12.5
Image: GUDMAP:7595
Note: caudal expression; specific restricted signal in caudal ovary may be associated with the signal seen in the mesentery and could represent a population of migrating cells
Specimen Label: GUDMAP:7595
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5758925
Assay Type: Immunohistochemistry
Annotation Date: 2016-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3561126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5758935
Age: embryonic day 20.5
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5758925
Assay Type: Immunohistochemistry
Annotation Date: 2016-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3561124
Stage: TS24
Assay Id: MGI:5758935
Age: embryonic day 16.5
Image: 7A
Specimen Label: 7A
Detected: false
Specimen Num: 7
GXD Expression
Probe: MGI:7423852
Assay Type: RNA in situ
Annotation Date: 2023-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3791721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7424898
Age: embryonic day 13.0
Image: S6 - E13 - D1
Note: The olfactory nerve layer OECs show expression.
Specimen Label: S6 - E13 - D1
Detected: true
Specimen Num: 3
Publication
First Author: Tamura H
Year: 2006
Journal: Neurosci Lett
Title: Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP.
Volume: 399
Issue: 1-2
Pages: 33-8
Publication
First Author: Lamprianou S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.
Volume: 108
Issue: 42
Pages: 17498-503
Publication
First Author: Nayak G
Year: 2011
Journal: Dev Neurobiol
Title: Evidence for multiple, developmentally regulated isoforms of Ptprq on hair cells of the inner ear.
Volume: 71
Issue: 2
Pages: 129-41
Publication
First Author: Himburg HA
Year: 2012
Journal: Cell Rep
Title: Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.
Volume: 2
Issue: 4
Pages: 964-75
Publication
First Author: Himburg HA
Year: 2014
Journal: J Clin Invest
Title: Pleiotrophin mediates hematopoietic regeneration via activation of RAS.
Volume: 124
Issue: 11
Pages: 4753-8
Publication
First Author: Fukazawa N
Year: 2008
Journal: Mol Cell Biol
Title: Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.
Volume: 28
Issue: 14
Pages: 4494-506
Publication  
First Author: Karus M
Year: 2012
Journal: Neural Dev
Title: Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiation.
Volume: 7
Pages: 20
Publication
First Author: Lee JK
Year: 2012
Journal: J Biol Chem
Title: Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.
Volume: 287
Issue: 34
Pages: 28526-36
Publication
First Author: Eill GJ
Year: 2020
Journal: J Biol Chem
Title: The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure.
Volume: 295
Issue: 4
Pages: 955-968
Publication
First Author: Baldauf C
Year: 2015
Journal: PLoS One
Title: The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.
Volume: 10
Issue: 9
Pages: e0137745
Publication
First Author: Dwyer CA
Year: 2015
Journal: J Biol Chem
Title: Neurons and glia modify receptor protein-tyrosine phosphatase ζ (RPTPζ)/phosphacan with cell-specific O-mannosyl glycans in the developing brain.
Volume: 290
Issue: 16
Pages: 10256-73
Publication
First Author: Bouyain S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.
Volume: 107
Issue: 6
Pages: 2443-8
Publication
First Author: Sakaguchi N
Year: 2003
Journal: Neurosci Res
Title: Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Volume: 45
Issue: 2
Pages: 219-24
Publication
First Author: Kuboyama K
Year: 2016
Journal: J Biol Chem
Title: Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.
Volume: 291
Issue: 35
Pages: 18117-28
Publication
First Author: Haunsø A
Year: 2000
Journal: Brain Res
Title: Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice.
Volume: 864
Issue: 1
Pages: 142-5
Publication
First Author: Karus M
Year: 2013
Journal: Neurochem Res
Title: Differential expression of micro-heterogeneous LewisX-type glycans in the stem cell compartment of the developing mouse spinal cord.
Volume: 38
Issue: 6
Pages: 1285-94
Publication
First Author: Tanga N
Year: 2019
Journal: Glia
Title: The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.
Volume: 67
Issue: 5
Pages: 967-984
Publication
First Author: Chow JP
Year: 2008
Journal: J Biol Chem
Title: Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.
Volume: 283
Issue: 45
Pages: 30879-89
Publication
First Author: Bekku Y
Year: 2009
Journal: J Neurochem
Title: Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.
Volume: 108
Issue: 5
Pages: 1266-76
Publication
First Author: Leung KM
Year: 2004
Journal: Brain Res Dev Brain Res
Title: Expression of phosphacan and neurocan during early development of mouse retinofugal pathway.
Volume: 152
Issue: 1
Pages: 1-10
Publication
First Author: Chow JP
Year: 2008
Journal: Neurosci Lett
Title: Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain.
Volume: 442
Issue: 3
Pages: 208-12
Publication
First Author: Nandi S
Year: 2013
Journal: J Biol Chem
Title: Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.
Volume: 288
Issue: 30
Pages: 21972-86
Publication
First Author: Garwood J
Year: 2003
Journal: J Biol Chem
Title: Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.
Volume: 278
Issue: 26
Pages: 24164-73
Publication
First Author: Cohen S
Year: 2012
Journal: J Immunol
Title: The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.
Volume: 188
Issue: 1
Pages: 259-69
Publication
First Author: Gonzalez-Gil A
Year: 2022
Journal: J Biol Chem
Title: Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.
Volume: 298
Issue: 6
Pages: 101960
Publication
First Author: Nagalakshmi VK
Year: 2015
Journal: Dev Dyn
Title: microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development.
Volume: 244
Issue: 3
Pages: 444-56
Publication
First Author: Clarris HJ
Year: 2000
Journal: J Comp Neurol
Title: Dynamic spatiotemporal expression patterns of neurocan and phosphacan indicate diverse roles in the developing and adult mouse olfactory system.
Volume: 423
Issue: 1
Pages: 99-111
Publication
First Author: Nguyen Ba-Charvet KT
Year: 1998
Journal: Development
Title: A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain.
Volume: 125
Issue: 21
Pages: 4273-82
Publication
First Author: Treloar HB
Year: 2009
Journal: J Neurosci
Title: Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb.
Volume: 29
Issue: 30
Pages: 9405-16
GXD Expression  
Probe: MGI:7423908
Assay Type: RNA in situ
Annotation Date: 2023-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689524
Pattern: Single cells
Stage: TS24
Assay Id: MGI:7425191
Age: embryonic day 16.5
Note: There is no significant difference in the number of GnRH neurons inside the forebrain of the mutant compared to wild type.
Specimen Label: Ptprz1 -/-
Detected: true
Specimen Num: 3
Publication  
First Author: Dwyer CA
Year: 2012
Journal: Neuroscience
Title: RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1.
Volume: 220
Pages: 47-61
Publication
First Author: Ohyama K
Year: 1998
Journal: Brain Res Dev Brain Res
Title: Coordinate expression of L1 and 6B4 proteoglycan/phosphacan is correlated with the migration of mesencephalic dopaminergic neurons in mice.
Volume: 107
Issue: 2
Pages: 219-26
Publication
First Author: Ohyama K
Year: 2004
Journal: Brain Res Dev Brain Res
Title: Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex.
Volume: 148
Issue: 1
Pages: 121-7
Publication
First Author: Klausmeyer A
Year: 2007
Journal: J Comp Neurol
Title: Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.
Volume: 504
Issue: 6
Pages: 659-79
Publication
First Author: Blackshear PJ
Year: 1997
Journal: Exp Neurol
Title: Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.
Volume: 145
Issue: 1
Pages: 46-61
Publication
First Author: Besser M
Year: 2012
Journal: Dev Biol
Title: Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment.
Volume: 369
Issue: 2
Pages: 163-76
Publication  
First Author: Schaberg E
Year: 2021
Journal: Front Cell Dev Biol
Title: Sulfation of Glycosaminoglycans Modulates the Cell Cycle of Embryonic Mouse Spinal Cord Neural Stem Cells.
Volume: 9
Pages: 643060
Publication
First Author: Bischof JM
Year: 2005
Journal: Physiol Genomics
Title: Genome-wide analysis of gene transcription in the hypothalamus.
Volume: 22
Issue: 2
Pages: 191-6
Publication
First Author: Maddala R
Year: 2011
Journal: Dev Biol
Title: Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.
Volume: 357
Issue: 1
Pages: 179-90
Publication
First Author: Hikake T
Year: 2003
Journal: Anat Embryol (Berl)
Title: Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.
Volume: 206
Issue: 5
Pages: 373-80
Publication
First Author: Nakagawa N
Year: 2019
Journal: Neuron
Title: Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
Volume: 103
Issue: 5
Pages: 836-852.e5
Publication
First Author: Horvat-Bröcker A
Year: 2008
Journal: Neuroscience
Title: Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina.
Volume: 152
Issue: 3
Pages: 618-45
Publication
First Author: Abramova N
Year: 2005
Journal: Dev Biol
Title: Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.
Volume: 283
Issue: 2
Pages: 269-81
Publication
First Author: Liu WA
Year: 2018
Journal: Genes Dev
Title: PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.
Volume: 32
Issue: 11-12
Pages: 763-780
Publication
First Author: Robel S
Year: 2009
Journal: Glia
Title: Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.
Volume: 57
Issue: 15
Pages: 1630-47
Publication
First Author: Shao W
Year: 2020
Journal: Nature
Title: Centrosome anchoring regulates progenitor properties and cortical formation.
Volume: 580
Issue: 7801
Pages: 106-112
Publication
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
Publication
First Author: Nagamachi A
Year: 2013
Journal: Cancer Cell
Title: Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Volume: 24
Issue: 3
Pages: 305-17
Publication    
First Author: Heng X
Year: 2017
Journal: Elife
Title: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
Volume: 6
Publication
First Author: Hecht J
Year: 2007
Journal: Gene Expr Patterns
Title: Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model.
Volume: 7
Issue: 1-2
Pages: 102-12
Publication    
First Author: Lee DR
Year: 2022
Journal: Elife
Title: Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
Volume: 11
Publication
First Author: Mayer C
Year: 2018
Journal: Nature
Title: Developmental diversification of cortical inhibitory interneurons.
Volume: 555
Issue: 7697
Pages: 457-462
Publication  
First Author: Yorgan TA
Year: 2019
Journal: Bone
Title: Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
Volume: 127
Pages: 155-163
Publication        
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
Publication
First Author: Loo L
Year: 2019
Journal: Nat Commun
Title: Single-cell transcriptomic analysis of mouse neocortical development.
Volume: 10
Issue: 1
Pages: 134
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Memic F
Year: 2018
Journal: Gastroenterology
Title: Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Volume: 154
Issue: 3
Pages: 624-636
Publication
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Interaction Experiment
Description: Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.