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Search results 101 to 115 out of 115 for Thoc1

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Type Details Score
Protein Domain
IPR021861 | THO_THOC1
Type: Family
Description: THO complex subunit 1 (THOC1; its homologues from plants and yeast HPR1) is a component of the THO subcomplex of the TREX complex, which is involved in coupling mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX plays central roles during mRNP (messenger ribonucleoprotein) maturation and export from the nucleus to the cytoplasm []. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase [, , ]. In plants, HPR1 plays a role in disease resistance [].
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Allele
Thoc1<em2Smoc> | MGI:7292777
Name: THO complex 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
Q8R3N6
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
A0A3Q4EBV8
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: true
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Publication
14527416 | -
First Author: Huertas P
Year: 2003
Journal: Mol Cell
Title: Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
Volume: 12
Issue: 3
Pages: 711-21
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Strain
MGI:6771215 | C57BL/6-Thoc1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Thoc1<em1Smoc> | MGI:7292776
Name: THO complex 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
17095540 | -
First Author: Merz C
Year: 2007
Journal: RNA
Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
Volume: 13
Issue: 1
Pages: 116-28
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Protein Domain
IPR021726 | THO_THOC2_N
Type: Domain
Description: The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats []. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex []. This entry represents a conserved domain found towards the N terminus of these proteins.
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Publication
33397987 | J:300953
First Author: Yu T
Year: 2021
Journal: Nat Commun
Title: Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes.
Volume: 12
Issue: 1
Pages: 73
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Protein
B1AZI6
Organism: Mus musculus/domesticus
Length: 1594  
Fragment?: false
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Protein
E9Q5E2
Organism: Mus musculus/domesticus
Length: 1589  
Fragment?: false
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Protein
Q3UYT9
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: true
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Protein
Q3US09
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: true
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Publication
9707445 | -
First Author: Piruat JI
Year: 1998
Journal: EMBO J
Title: A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.
Volume: 17
Issue: 16
Pages: 4859-72
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