Rab-like protein 6 (RABL6 or RBEL1) is one of several proteins identified as binding partners of the ARF tumour suppressor, which protects against cancer through protein-protein interactions, interacting with CDKN2A []. RABL6 binds GTP and is found either in the cytoplasm or the nucleus depending in the isoform; isoform 1 is O-glycosylated and cytoplasmic [].