In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation []. In plants this family includes , which is involved in water permeability in the cuticles of fruit []. has been found to be expressed during early embryogenesis in mice []. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.
