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Search results 1 to 95 out of 95 for Bscl2

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Category: Publication
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Type Details Score
Publication
24358199 | J:211142
First Author: Chen W
Year: 2013
Journal: PLoS One
Title: Altered lipid metabolism in residual white adipose tissues of Bscl2 deficient mice.
Volume: 8
Issue: 12
Pages: e82526
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Publication
31185001 | J:287909
   
First Author: Zhou H
Year: 2019
Journal: JCI Insight
Title: Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy.
Volume: 5
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Publication
30552349 | J:268439
First Author: Mcilroy GD
Year: 2018
Journal: Sci Rep
Title: Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.
Volume: 8
Issue: 1
Pages: 17863
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Publication
33498782 | J:320952
 
First Author: Roumane A
Year: 2021
Journal: J Clin Med
Title: Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy.
Volume: 10
Issue: 3
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Publication
27748422 | J:249911
 
First Author: Dollet L
Year: 2016
Journal: Sci Rep
Title: Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode.
Volume: 6
Pages: 35487
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Publication
23680914 | J:200947
First Author: Prieur X
Year: 2013
Journal: Diabetologia
Title: Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice.
Volume: 56
Issue: 8
Pages: 1813-25
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Publication
35145475 | J:320109
 
First Author: McGrath C
Year: 2021
Journal: Front Endocrinol (Lausanne)
Title: Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.
Volume: 12
Pages: 782194
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Publication
29088395 | J:247896
First Author: Zowalaty AEE
Year: 2017
Journal: Biol Reprod
Title: Seipin deficiency leads to defective parturition in mice.
Volume: 97
Issue: 3
Pages: 378-386
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Publication
29236949 | J:262654
First Author: El Zowalaty AE
Year: 2018
Journal: Biol Reprod
Title: Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation.
Volume: 98
Issue: 4
Pages: 570-578
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Publication
26269358 | J:226025
First Author: Zhou H
Year: 2015
Journal: J Lipid Res
Title: Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals.
Volume: 56
Issue: 10
Pages: 1912-25
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Publication
26181198 | J:333297
First Author: El Zowalaty AE
Year: 2015
Journal: Cell Death Dis
Title: Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility.
Volume: 6
Issue: 7
Pages: e1817
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Publication
31776610 | J:285227
First Author: Xiong J
Year: 2020
Journal: Diabetologia
Title: Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARĪ³ expression.
Volume: 63
Issue: 2
Pages: 338-350
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Publication
28052965 | J:249396
First Author: Joubert M
Year: 2017
Journal: Diabetes
Title: The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model.
Volume: 66
Issue: 4
Pages: 1030-1040
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Publication
27554469 | J:249468
First Author: Dollet L
Year: 2016
Journal: Diabetes
Title: FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency.
Volume: 65
Issue: 11
Pages: 3410-3417
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Publication
31848133 | J:284065
 
First Author: Mcilroy GD
Year: 2020
Journal: Dis Model Mech
Title: Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy.
Volume: 13
Issue: 1
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Publication
24622797 | J:229489
First Author: Liu L
Year: 2014
Journal: Diabetes
Title: Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy.
Volume: 63
Issue: 7
Pages: 2320-31
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Publication
22269949 | J:183701
First Author: Chen W
Year: 2012
Journal: Mol Cell Biol
Title: Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation.
Volume: 32
Issue: 6
Pages: 1099-111
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Publication
30521848 | J:273218
 
First Author: Xu W
Year: 2019
Journal: Mol Cell Endocrinol
Title: Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice.
Volume: 482
Pages: 1-10
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Publication
25093462 | J:218333
First Author: Chen W
Year: 2014
Journal: Endocrinology
Title: Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice.
Volume: 155
Issue: 11
Pages: 4215-25
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Publication
31909301 | J:302911
First Author: Bai B
Year: 2019
Journal: JACC Basic Transl Sci
Title: Seipin Knockout Mice Develop HeartĀ Failure With Preserved EjectionĀ Fraction.
Volume: 4
Issue: 8
Pages: 924-937
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Publication
34638939 | J:320800
 
First Author: Bruder-Nascimento T
Year: 2021
Journal: Int J Mol Sci
Title: Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy.
Volume: 22
Issue: 19
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Publication
33778025 | J:307874
 
First Author: Wu X
Year: 2021
Journal: Front Cardiovasc Med
Title: Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice.
Volume: 8
Pages: 644128
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Publication
27287266 | J:285076
First Author: Qian Y
Year: 2016
Journal: J Neuroinflammation
Title: Neuronal seipin knockout facilitates AĪ²-induced neuroinflammation and neurotoxicity via reduction of PPARĪ³ in hippocampus of mouse.
Volume: 13
Issue: 1
Pages: 145
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Publication
27109482 | J:235397
First Author: Chen Y
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Seinpin knockout exacerbates cerebral ischemia/reperfusion damage in mice.
Volume: 474
Issue: 2
Pages: 377-383
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Publication
30457912 | J:274024
First Author: Wang H
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice.
Volume: 316
Issue: 1
Pages: E54-E62
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Publication
29738274 | J:282753
First Author: Liu XJ
Year: 2018
Journal: FASEB J
Title: Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk.
Volume: 32
Issue: 10
Pages: 5550-5562
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Publication
21551454 | J:173404
First Author: Cui X
Year: 2011
Journal: Hum Mol Genet
Title: Seipin ablation in mice results in severe generalized lipodystrophy.
Volume: 20
Issue: 15
Pages: 3022-30
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Publication
31873720 | J:288248
First Author: Gao M
Year: 2020
Journal: Hum Mol Genet
Title: GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy.
Volume: 29
Issue: 3
Pages: 432-443
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Publication
29459250 | J:260853
 
First Author: Mcilroy GD
Year: 2018
Journal: Mol Metab
Title: Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease.
Volume: 10
Pages: 55-65
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Publication
24778225 | J:211072
First Author: Jiang M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Lack of testicular seipin causes teratozoospermia syndrome in men.
Volume: 111
Issue: 19
Pages: 7054-9
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Publication
21737754 | J:176075
First Author: Peng XG
Year: 2011
Journal: J Lipid Res
Title: Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy.
Volume: 52
Issue: 10
Pages: 1847-55
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Publication
27806294 | J:242338
First Author: Pagac M
Year: 2016
Journal: Cell Rep
Title: SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.
Volume: 17
Issue: 6
Pages: 1546-1559
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Publication
29428127 | J:271940
 
First Author: Liao J
Year: 2018
Journal: Gene
Title: Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion.
Volume: 648
Pages: 82-88
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Publication
30910747 | J:278137
 
First Author: Chang H
Year: 2019
Journal: Neurobiol Dis
Title: Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARĪ³ and insulin resistance.
Volume: 127
Pages: 350-361
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Publication
25866184 | J:228386
First Author: Wang M
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Dysfunction of lipid metabolism in lipodystrophic Seipin-deficient mice.
Volume: 461
Issue: 2
Pages: 206-10
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Publication
26921684 | J:251544
First Author: Wang M
Year: 2016
Journal: Biochim Biophys Acta
Title: Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice.
Volume: 1861
Issue: 5
Pages: 410-8
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Publication
35021082 | J:322568
First Author: Combot Y
Year: 2022
Journal: Cell Rep
Title: Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.
Volume: 38
Issue: 2
Pages: 110213
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Publication
27087445 | J:234498
First Author: Romere C
Year: 2016
Journal: Cell
Title: Asprosin, a Fasting-Induced Glucogenic Protein Hormone.
Volume: 165
Issue: 3
Pages: 566-79
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Publication
24651066 | J:210974
First Author: Zhou L
Year: 2014
Journal: Hum Mol Genet
Title: Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARĪ³.
Volume: 23
Issue: 15
Pages: 4094-102
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Publication
18585921 | J:139166
First Author: Ito D
Year: 2008
Journal: Neurobiol Dis
Title: Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17.
Volume: 31
Issue: 2
Pages: 266-77
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Publication
12584444 | J:82436
First Author: Kaisaki PJ
Year: 2002
Journal: Cytogenet Genome Res
Title: Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus.
Volume: 98
Issue: 1
Pages: 71-4
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Publication
23458123 | J:198139
First Author: Yang W
Year: 2013
Journal: Biochem J
Title: Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus.
Volume: 452
Issue: 1
Pages: 37-44
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Publication
26398946 | J:226846
First Author: Li G
Year: 2015
Journal: Dis Model Mech
Title: Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARĪ³.
Volume: 8
Issue: 12
Pages: 1615-24
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Publication
32246911 | J:305811
 
First Author: Zhou H
Year: 2020
Journal: Mol Metab
Title: Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing.
Volume: 36
Pages: 100971
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Publication
31656096 | J:327446
First Author: Bruder-Nascimento T
Year: 2019
Journal: Hypertension
Title: Leptin Restores Endothelial Function via Endothelial PPARĪ³-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy.
Volume: 74
Issue: 6
Pages: 1399-1408
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Publication
23149622 | J:195942
First Author: Peng XG
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and (1)H-MR spectroscopy.
Volume: 304
Issue: 2
Pages: E160-7
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Publication
26818512 | J:231465
First Author: Zhou L
Year: 2016
Journal: J Neurosci
Title: Activation of PPARĪ³ Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice.
Volume: 36
Issue: 4
Pages: 1242-53
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Publication
23173741 | J:193536
First Author: Wei S
Year: 2013
Journal: J Neurochem
Title: Seipin regulates excitatory synaptic transmission in cortical neurons.
Volume: 124
Issue: 4
Pages: 478-89
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Publication
15314181 | J:92791
First Author: Schwindinger WF
Year: 2004
Journal: Mol Cell Biol
Title: Mice with deficiency of G protein gamma3 are lean and have seizures.
Volume: 24
Issue: 17
Pages: 7758-68
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27185876 | J:236180
First Author: Zhou H
Year: 2016
Journal: Mol Cell Biol
Title: Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function.
Volume: 36
Issue: 15
Pages: 2027-38
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Publication
24026679 | J:204619
First Author: Yang W
Year: 2014
Journal: Hum Mol Genet
Title: BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling.
Volume: 23
Issue: 2
Pages: 502-13
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Publication
9790771 | J:50600
First Author: Downes GB
Year: 1998
Journal: Genomics
Title: Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg.
Volume: 53
Issue: 2
Pages: 220-30
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14517553 | J:86371
First Author: Floyd JA
Year: 2003
Journal: Nat Genet
Title: A natural allele of Nxf1 suppresses retrovirus insertional mutations.
Volume: 35
Issue: 3
Pages: 221-8
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10679242 | J:64911
First Author: Inoue S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains.
Volume: 268
Issue: 2
Pages: 553-61
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31097699 | J:275567
First Author: Zurkirchen L
Year: 2019
Journal: Nat Commun
Title: Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Volume: 10
Issue: 1
Pages: 2192
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16964442 | J:112870
First Author: Mager J
Year: 2006
Journal: Mamm Genome
Title: Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Volume: 17
Issue: 9
Pages: 941-9
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21308776 | J:233118
First Author: Abdallah BM
Year: 2011
Journal: J Bone Miner Res
Title: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Volume: 26
Issue: 7
Pages: 1457-71
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29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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23049863 | -
First Author: Garfield AS
Year: 2012
Journal: PLoS One
Title: Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain.
Volume: 7
Issue: 9
Pages: e45790
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30970241 | J:284991
First Author: Li D
Year: 2019
Journal: Cell Rep
Title: The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
Volume: 27
Issue: 2
Pages: 343-358.e5
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Publication
25934999 | J:226956
First Author: Ebihara C
Year: 2015
Journal: Hum Mol Genet
Title: Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.
Volume: 24
Issue: 15
Pages: 4238-49
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27638887 | J:239250
First Author: RenvoisƩ B
Year: 2016
Journal: Hum Mol Genet
Title: Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation.
Volume: 25
Issue: 23
Pages: 5111-5125
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22234369 | J:184643
First Author: Cui X
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy.
Volume: 302
Issue: 6
Pages: E705-13
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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