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Search results 301 to 359 out of 359 for Smc4

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Type Details Score
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR012371 | NCAPD3
Type: Family
Description: This group contains condensin-2 complex subunit D3. It is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2), a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [, ].
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Protein Domain
IPR026971 | CND1/NCAPD3
Type: Family
Description: This entry includes condensin subunit 1 (CND1) and condensin-2 complex subunit D3 (NCAPD3).CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes []. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [, , , ]. NCAPD3 is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2), a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [].
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HT Experiment
GSE158166 | Single cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
34789782 | J:314667
First Author: Bais AS
Year: 2021
Journal: Sci Rep
Title: Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis.
Volume: 11
Issue: 1
Pages: 22434
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Publication
11854418 | -
First Author: Bhalla N
Year: 2002
Journal: Mol Biol Cell
Title: Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior.
Volume: 13
Issue: 2
Pages: 632-45
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Protein Domain
IPR041738 | SMC4_ABC_euk
Type: Domain
Description: The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 [].This entry represents the ATP-binding cassette domain of eukaryotic SMC4 proteins.
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Protein
A0A087WNQ1
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
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Publication
11136719 | -
First Author: Kimura K
Year: 2001
Journal: J Biol Chem
Title: Chromosome condensation by a human condensin complex in Xenopus egg extracts.
Volume: 276
Issue: 8
Pages: 5417-20
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Publication
14532007 | -
First Author: Ono T
Year: 2003
Journal: Cell
Title: Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.
Volume: 115
Issue: 1
Pages: 109-21
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Publication
27737959 | J:242515
First Author: Martin CA
Year: 2016
Journal: Genes Dev
Title: Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.
Volume: 30
Issue: 19
Pages: 2158-2172
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Protein Domain
IPR007673 | Condensin_cplx_su1
Type: Family
Description: This entry includes condensin subunit 1 (CND1). CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes []. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [, , , ]. Condensin is a multi-subunit protein complex that acts as an essential regulator of chromosome condensation [, ]. It contains both SMC (structural maintenance of chromosomes) and non-SMC subunits. Condensin plays an important role during mitosis in the compaction and resolution of chromosomes to remove and prevent catenations that would otherwise inhibit segregation. This is thought to be achieved by the introduction of positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. During interphase condensin promotes clustering of dispersed loci into subnuclear domains and inhibits associations between homologues. In meiosis, condensin has been shown to influence the number of crossover events by regulating programmed double-strand breaks. Roles in gene regulation and lymphocyte development have also been defined.
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Protein
D6RGR7
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: false
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Protein Domain
IPR031719 | H2_M
Type: Domain
Description: This is the middle domain of the H2 subunit of the condensin II complex, found in eukaryotes but not fungi. This region represents the disordered section of CNDH2 between the N- and the C-terminal domains.Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits. The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII are concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi. CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2. All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex). The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit. The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII [, ].
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Protein Domain
IPR009378 | H2_N
Type: Domain
Description: This entry represents the N-terminal domain of the H2 subunit of the condensing II complex, found in eukaryotes but not in fungi. Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits. The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII is concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi. CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2. All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex). The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit. The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII [, ].
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Protein
Q6ZQK0
Organism: Mus musculus/domesticus
Length: 1506  
Fragment?: false
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Protein
A0EQY3
Organism: Mus musculus/domesticus
Length: 1506  
Fragment?: false
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Protein
K4DI67
Organism: Mus musculus/domesticus
Length: 1506  
Fragment?: false
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Protein
Q3UTU7
Organism: Mus musculus/domesticus
Length: 1506  
Fragment?: false
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Protein
Q80W41
Organism: Mus musculus/domesticus
Length: 1223  
Fragment?: false
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Publication
12138188 | -
First Author: Ball AR Jr
Year: 2002
Journal: Mol Cell Biol
Title: Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.
Volume: 22
Issue: 16
Pages: 5769-81
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Publication
9774278 | -
First Author: Kimura K
Year: 1998
Journal: Science
Title: Phosphorylation and activation of 13S condensin by Cdc2 in vitro.
Volume: 282
Issue: 5388
Pages: 487-90
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Protein
Q8K2Z4
Organism: Mus musculus/domesticus
Length: 1392  
Fragment?: false
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Protein
A0A0R4J0H7
Organism: Mus musculus/domesticus
Length: 1392  
Fragment?: false
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Protein
Q3UZJ7
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: true
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Protein
Q3U763
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: true
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Protein
Q8BSP2
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Protein
E9PY48
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Publication
22855829 | -
First Author: Hirano T
Year: 2012
Journal: Genes Dev
Title: Condensins: universal organizers of chromosomes with diverse functions.
Volume: 26
Issue: 15
Pages: 1659-78
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Publication
20442714 | -
First Author: Wood AJ
Year: 2010
Journal: Nat Rev Genet
Title: Condensin and cohesin complexity: the expanding repertoire of functions.
Volume: 11
Issue: 6
Pages: 391-404
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Protein
Q8CG47
Organism: Mus musculus/domesticus
Length: 1286  
Fragment?: false
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Protein
Q6P7V9
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
E9Q2X6
Organism: Mus musculus/domesticus
Length: 1261  
Fragment?: false
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Publication
11864377 | -
First Author: Harvey SH
Year: 2002
Journal: Genome Biol
Title: Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases.
Volume: 3
Issue: 2
Pages: REVIEWS3003
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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