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Search results 401 to 500 out of 514 for Grm3

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Type Details Score
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3639194
Age: postnatal day 49
Specimen Label: Mouse 436442
Detected: false
Specimen Num: 25
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Very strong
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639194
Age: postnatal day 49
Image: Mouse 436442 - Image 99245808
Note: Expression is present in practically all cells of the brain.
Specimen Label: Mouse 436442 - Image 99245808
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691496
Age: postnatal adult
Image: MRC Harwell_892253
Specimen Label: MRC Harwell_892253
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691496
Age: postnatal adult
Image: MRC Harwell_892257
Specimen Label: MRC Harwell_892257
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691496
Age: postnatal adult
Image: MRC Harwell_892259
Specimen Label: MRC Harwell_892259
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Strong
Sex: Male
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639194
Age: postnatal day 49
Image: Mouse 436438 - Image 99247119
Note: There is scattered expression in the granule layer.
Specimen Label: Mouse 436438 - Image 99247119
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5707690
Assay Type: Immunohistochemistry
Annotation Date: 2016-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5707694
Age: postnatal adult
Note: Expression was detected in Goli cells. Co-expression with Gad1 and Kcnj6 was noted on some cells.
Specimen Label: 6C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5707690
Assay Type: Immunohistochemistry
Annotation Date: 2016-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5707694
Age: postnatal adult
Note: Expression was detected in Goli cells. Some cells were noted that did not co-express Gad1 and Kcnj6.
Specimen Label: 6D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3639194
Age: postnatal day 49
Specimen Label: Mouse 436442
Detected: false
Specimen Num: 25
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691496
Age: postnatal adult
Image: MRC Harwell_892247
Specimen Label: MRC Harwell_892247
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3724332
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5420992
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH371; Specimen C1114
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3724332
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826626
Stage: TS26
Assay Id: MGI:5540356
Age: embryonic day 17.5
Image: GUDMAP:15487
Specimen Label: GUDMAP:15487
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3724332
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2826628
Stage: TS28
Assay Id: MGI:5540356
Age: postnatal day 84
Image: GUDMAP:15488
Specimen Label: GUDMAP:15488
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3724332
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772126
Stage: TS26
Assay Id: MGI:5540356
Age: embryonic day 17.5
Image: GUDMAP:15487
Specimen Label: GUDMAP:15487
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3724332
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5420992
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH371; Specimen C1114
Detected: false
Specimen Num: 1
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Publication
28285415 | J:264962
First Author: Olszewski RT
Year: 2017
Journal: Neurochem Res
Title: NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Volume: 42
Issue: 9
Pages: 2646-2657
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Publication
24053122 | J:202321
 
First Author: Lane TA
Year: 2013
Journal: BMC Neurosci
Title: Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.
Volume: 14
Pages: 102
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Publication
21628565 | J:173317
First Author: Ster J
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Volume: 108
Issue: 24
Pages: 9993-7
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Publication
27911756 | J:273178
First Author: Rosenberg N
Year: 2016
Journal: J Neurosci
Title: Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.
Volume: 36
Issue: 45
Pages: 11521-11531
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Publication
25950516 | J:235346
First Author: Pritchett D
Year: 2015
Journal: PLoS One
Title: Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.
Volume: 10
Issue: 5
Pages: e0125523
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Publication
17670976 | J:123686
First Author: Corti C
Year: 2007
Journal: J Neurosci
Title: The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.
Volume: 27
Issue: 31
Pages: 8297-308
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Publication
24291464 | J:215281
 
First Author: Durand D
Year: 2014
Journal: Neuropharmacology
Title: Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.
Volume: 79
Pages: 180-9
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Publication
25434487 | J:218605
 
First Author: Battaglia G
Year: 2015
Journal: Neurobiol Dis
Title: Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.
Volume: 74
Pages: 126-36
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Publication
25583490 | J:219273
First Author: Walker AG
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Volume: 112
Issue: 4
Pages: 1196-201
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Publication
30939596 | J:294666
First Author: Highland JN
Year: 2019
Journal: Neuropsychopharmacology
Title: Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.
Volume: 44
Issue: 10
Pages: 1788-1796
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Publication
7965099 | J:21416
First Author: Chavis P
Year: 1994
Journal: J Neurosci
Title: The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Volume: 14
Issue: 11 Pt 2
Pages: 7067-76
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Publication
8838577 | J:31160
First Author: Bergmann M
Year: 1996
Journal: J Neurosci Res
Title: Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.
Volume: 43
Issue: 1
Pages: 78-86
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Publication
8915890 | J:36610
First Author: Winder DG
Year: 1996
Journal: J Neurosci Res
Title: Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication.
Volume: 46
Issue: 2
Pages: 131-7
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Publication
23307741 | J:193245
First Author: Sun W
Year: 2013
Journal: Science
Title: Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.
Volume: 339
Issue: 6116
Pages: 197-200
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Publication
23616537 | J:196948
First Author: Brunner J
Year: 2013
Journal: J Neurosci
Title: Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.
Volume: 33
Issue: 17
Pages: 7285-98
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Publication
27818290 | J:237209
First Author: McOmish CE
Year: 2016
Journal: Gene Expr Patterns
Title: Developmental expression of mGlu2 and mGlu3 in the mouse brain.
Volume: 22
Issue: 2
Pages: 46-53
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Publication
30040841 | J:265812
First Author: Berry S
Year: 2018
Journal: PLoS One
Title: Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.
Volume: 13
Issue: 7
Pages: e0200896
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Publication
7722646 | J:24532
First Author: Duvoisin RM
Year: 1995
Journal: J Neurosci
Title: A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb.
Volume: 15
Issue: 4
Pages: 3075-83
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Publication
31735403 | J:283385
First Author: Joffe ME
Year: 2020
Journal: Neuron
Title: mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.
Volume: 105
Issue: 1
Pages: 46-59.e3
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Publication
34245686 | J:314414
First Author: Kellner V
Year: 2021
Journal: Neuron
Title: Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains.
Volume: 109
Issue: 16
Pages: 2545-2555.e7
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Publication
25781000 | J:329119
First Author: Kupferschmidt DA
Year: 2015
Journal: J Physiol
Title: Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.
Volume: 593
Issue: 10
Pages: 2295-310
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Publication
29079293 | J:283292
 
First Author: Di Menna L
Year: 2018
Journal: Neuropharmacology
Title: Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.
Volume: 128
Pages: 301-313
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Publication
15619115 | J:113260
First Author: Linden AM
Year: 2005
Journal: Psychopharmacology (Berl)
Title: Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.
Volume: 179
Issue: 1
Pages: 284-91
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Publication
19477188 | J:155779
First Author: Linden AM
Year: 2009
Journal: Neuropharmacology
Title: Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.
Volume: 57
Issue: 2
Pages: 172-82
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Publication
16733060 | J:111663
First Author: Linden AM
Year: 2006
Journal: Neuropharmacology
Title: Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.
Volume: 51
Issue: 2
Pages: 213-28
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Publication
29024663 | J:256101
First Author: Nasca C
Year: 2017
Journal: Neuron
Title: Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Volume: 96
Issue: 2
Pages: 402-413.e5
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Publication
23261870 | J:193529
 
First Author: Aguado C
Year: 2013
Journal: J Chem Neuroanat
Title: Differential maturation of GIRK2-expressing neurons in the mouse cerebellum.
Volume: 47
Pages: 79-89
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Publication
27056679 | J:233703
First Author: Schmitz SK
Year: 2016
Journal: EMBO J
Title: Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.
Volume: 35
Issue: 11
Pages: 1236-50
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Publication
9920659 | J:52411
First Author: Masugi M
Year: 1999
Journal: J Neurosci
Title: Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.
Volume: 19
Issue: 3
Pages: 955-63
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Publication
9069281 | J:39076
First Author: Kaupmann K
Year: 1997
Journal: Nature
Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Volume: 386
Issue: 6622
Pages: 239-46
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Publication
12074840 | J:101575
First Author: Fukami S
Year: 2002
Journal: Neurosci Res
Title: Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
Volume: 43
Issue: 1
Pages: 39-56
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Publication
15579147 | J:101279
First Author: Nakamura M
Year: 2004
Journal: Eur J Neurosci
Title: Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.
Volume: 20
Issue: 11
Pages: 2929-44
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Publication
22243746 | J:179898
First Author: Coate TM
Year: 2012
Journal: Neuron
Title: Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.
Volume: 73
Issue: 1
Pages: 49-63
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Publication
30926747 | J:275806
First Author: Wu D
Year: 2019
Journal: J Neurosci
Title: A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype.
Volume: 39
Issue: 22
Pages: 4252-4267
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Publication
31665922 | J:292850
First Author: Imbriglio T
Year: 2019
Journal: FASEB J
Title: Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.
Volume: 33
Issue: 12
Pages: 14204-14220
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Publication
35746896 | J:335422
First Author: Špirková A
Year: 2022
Journal: Biol Reprod
Title: Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Volume: 107
Issue: 4
Pages: 916-927
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Publication
21192082 | J:171106
First Author: Suzuki-Hirano A
Year: 2011
Journal: J Comp Neurol
Title: Dynamic spatiotemporal gene expression in embryonic mouse thalamus.
Volume: 519
Issue: 3
Pages: 528-43
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
17953485 | J:127119
First Author: Visel A
Year: 2007
Journal: PLoS Genet
Title: Regulatory pathway analysis by high-throughput in situ hybridization.
Volume: 3
Issue: 10
Pages: 1867-83
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Publication
19554387 | J:156036
First Author: Schilling K
Year: 2009
Journal: Cerebellum
Title: The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.
Volume: 8
Issue: 4
Pages: 477-89
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
31925813 | -
First Author: Gregory JM
Year: 2020
Journal: Neuropathol Appl Neurobiol
Title: Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.
Volume: 46
Issue: 5
Pages: 441-457
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Publication
35095492 | J:326684
 
First Author: Yao Y
Year: 2021
Journal: Front Pharmacol
Title: Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations.
Volume: 12
Pages: 775328
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Publication
8840013 | -
First Author: Makoff A
Year: 1996
Journal: Brain Res Mol Brain Res
Title: Molecular characterization and localization of human metabotropic glutamate receptor type 3.
Volume: 40
Issue: 1
Pages: 55-63
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Publication
28114282 | -
First Author: Yi H
Year: 2017
Journal: Oncogene
Title: The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis.
Volume: 36
Issue: 24
Pages: 3477-3489
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Publication
30488581 | -
First Author: Huang CY
Year: 2018
Journal: Cancer Med
Title: Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.
Volume: 7
Issue: 12
Pages: 6104-6111
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Protein Domain
IPR001234 | GPCR_3_mGluR3
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.GRM3 is brain-specific, and is expressed in neurones in the cerebral cortex, caudate-putamen,thalamus and cerebellum []. GRM3 inhibits adenylyl cyclase through apertussis-toxin-sensitive G-protein, probably of the Gi/Go class. It has been related to neurological diseases such as amyotrophic lateral sclerosis []and to cancer [, ].
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Protein
Q9QYS2
Organism: Mus musculus/domesticus
Length: 879  
Fragment?: false
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Protein
Q6PAT5
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: true
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Publication
1320017 | -
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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