The Notch signaling pathway regulates genes involved in cell fate decision throughout development. Its activity relies notably on the CSL transcription factors. BEND6 is a BEN-solo (bears a single BEN domain) factor that binds CSL via its BEN domain and acts as a CSL co-repressor. BEND6 associates with and represses Notch target genes, antagonizing Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis [].
