This superfamily includes a domain found in the human RPAP2 (RNAP II associated polypeptide) protein and in the yeast Rtr1 protein []. It has been suggested that this group of proteins are regulators of core RNA polymerase II function [].
This entry represents a domain found in RPAP2 (RNAP II associated polypeptide) protein and the yeast Rtr1 proteins. It has been suggested that this family of proteins are regulators of core RNA polymerase II function [].
This entry includes Rtr1/2 from budding yeasts and its homologues, including RPAP2 from humans. Homologues are known from animals, plants and fungi. Rtr1 and Rtr2 are paralogues. Rtr1 is a RNA polymerase II (RNAPII)-binding protein. It is responsible for the transition of PolII into the elongation and termination phases of transcription by removing RNAPII CTD serine 5 phosphorylation (Ser5-P) at a selection of target genes [, ].Human RPAP2 is a CTD phosphatase that interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3'-end formation [].
