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Search results 401 to 500 out of 500 for Raf1

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Type Details Score
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 216
Description: Phosphothreonine; by PKC/PRKCA and RAF1
Type: modified residue
End: 216
Publication
First Author: Hausherr CK
Year: 2006
Journal: Mol Carcinog
Title: Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model.
Volume: 45
Issue: 5
Pages: 302-8
Allele
Name: v-raf-leukemia viral oncogene 1; targeted mutation 2.1, Toshiyuki Araki
Allele Type: Targeted
Attribute String: Not Specified
Allele
Name: v-raf-leukemia viral oncogene 1; targeted mutation 1.1, Benjamin G Neel
Allele Type: Targeted
Attribute String: Not Specified
UniProt Feature
Begin: 694
Description: Phosphothreonine; by ROCK1, ROCK2, CDC42BP, ZIPK/DAPK3 and RAF1
Type: modified residue
End: 694
Publication
First Author: Ramakrishna G
Year: 2002
Journal: Toxicol Appl Pharmacol
Title: Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Volume: 179
Issue: 1
Pages: 21-34
Allele
Name: v-raf-leukemia viral oncogene 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Genotype
Symbol: Raf1/Raf1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCr
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Raf1/Raf1
Background: involves: 129S6/SvEvTac * C57BL/6NCr
Zygosity: hm
Has Mutant Allele: true
DO Term
UniProt Feature
Begin: 112
Description: Phosphoserine; by PKA, PKB, PIM2, PIM3, PAK1, PAK2, PAK4, PAK5, RPS6KA1 AND RAF1
Type: modified residue
End: 112
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
DO Term
Publication
First Author: Smith J
Year: 2009
Journal: Exp Cell Res
Title: Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.
Volume: 315
Issue: 13
Pages: 2241-8
DO Term
Publication
First Author: Deiss K
Year: 2012
Journal: J Biol Chem
Title: Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.
Volume: 287
Issue: 28
Pages: 23407-17
Allele
Name: v-raf-leukemia viral oncogene 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Publication
First Author: Jones DT
Year: 2009
Journal: Oncogene
Title: Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
Volume: 28
Issue: 20
Pages: 2119-23
Allele
Name: transgene insertion 87, Ulf R Rapp
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Protein Domain
Type: Family
Description: Ribulose-1,5-bis-phosphate carboxylase/oxygenase (Rubisco) is the rate-limiting carbon fixing enzyme of photosynthesis. Rubisco is a complex of eight large (RbcL) and eight small (RbcS) subunits that requires assembly chaperones. Rubisco accumulation factor 1 (Raf1) is a mayor chaperone involved in Rubisco assembly []. It acts downstream of chaperonin-assisted RbcL folding by stabilizing RbcL antiparallel dimers for assembly into RbcL8 complexes with four Raf1 dimers bound. Raf1 displacement by RbcS results in holoenzyme formation [, ]. It might regulate RuBisCO condensation and decondensation [].This protein family includes Raf1 proteins from cyanobacteria.
Publication
First Author: Li W
Year: 2000
Journal: Genes Dev
Title: The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Volume: 14
Issue: 8
Pages: 895-900
Publication
First Author: Rodriguez-Viciana P
Year: 2006
Journal: Mol Cell
Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Volume: 22
Issue: 2
Pages: 217-30
Publication
First Author: Cordeddu V
Year: 2009
Journal: Nat Genet
Title: Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
Volume: 41
Issue: 9
Pages: 1022-6
Publication
First Author: Selfors LM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Volume: 95
Issue: 12
Pages: 6903-8
Protein Domain
Type: Family
Description: Leucine-rich repeat protein SHOC2 is a regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, it targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialised signaling complexes [, ]. In humans, defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) []. In Caenorhabditis elegans the homologue is known as Soc2 [].
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Londhe KB
Year: 2012
Journal: PLoS One
Title: A cross-platform comparison of genome-wide expression changes of laser microdissected lung tissue of C-Raf transgenic mice using 3'IVT and exon array.
Volume: 7
Issue: 7
Pages: e40778
Genotype
Symbol: Tg(SFTPC-RAF1)87Urr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Protein Domain
Type: Domain
Description: This is the C-terminal domain, also known as the beta domain, of Rubsico Assembly Chaperone protein (Raf1). Raf1 is necessary for rubisco to catalyze the rate-limiting step of carbon fixation through carboxylating the five-carbon sugar substrate ribulose-1,5-bisphosphate. The beta domains primary function is dimerization, which is critical for Raf1 to achieve the necessary avidity for complex formation with RbcL (the large complex sub-unbit of Rubsico) assembly intermediates. The beta domain is also involved, to a small extent, in binding to RbcL with use of the lustiness near the beta domain's conserved top surface [].
Allele
Name: transgene insertion 1, Ulf R Rapp
Allele Type: Transgenic
Attribute String: Constitutively active, Humanized sequence, Inserted expressed sequence
Publication
First Author: Sasaki A
Year: 2003
Journal: Nat Cell Biol
Title: Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Volume: 5
Issue: 5
Pages: 427-32
Publication
First Author: Li M
Year: 2014
Journal: Gynecol Endocrinol
Title: SPRY4-mediated ERK1/2 signaling inhibition abolishes 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell.
Volume: 30
Issue: 8
Pages: 600-4
Publication
First Author: Fukaya T
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression.
Volume: 447
Issue: 3
Pages: 471-8
Protein Domain
Type: Domain
Description: This is the N-terminal alpha helical domain found in Rubisco accumulation factor1 (Raf1). Raf1 from Arabidopsis thaliana consists of an N-terminal alpha-domain, a flexible linker segment and a C-terminal β-sheet domain that mediates dimerization. The α-domains mediate the majority of functionally important contacts with RbcL (Rubisco large subunits) by bracketing each RbcL dimer at the top and bottom. The alpha-domain alone is essentially inactive [].
Protein Domain
Type: Family
Description: Protein sprouty homologue 4 (SPRY4) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY4 is a feedback negative regulator of FGFs-induced ERK1/2 signalling. It suppresses Ras-independent ERK activation by binding to Raf1 []. It may function as a tumour suppressor in endometrial adenocarcinoma []. It plays a critical role in developing inflammatory Th17 cells in Th17 cell-driven autoimmune diseases [].
Protein Domain
Type: Domain
Description: This is helix turn helix domain found in alpha helical region of Rubisco accumulation factor1 (Raf1). Raf1 from Arabidopsis thaliana consists of an N-terminal alpha-domain, a flexible linker segment and a C-terminal β-sheet domain that mediates dimerization. The α-domains mediate the majority of functionally important contacts with RbcL (Rubisco large subunits) by bracketing each RbcL dimer at the top and bottom. The alpha-domain alone is essentially inactive [].
Publication
First Author: Olschläger V
Year: 2004
Journal: Oncogene
Title: Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice.
Volume: 23
Issue: 39
Pages: 6639-46
Publication
First Author: Rütters H
Year: 2006
Journal: Proteomics
Title: Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice.
Volume: 6
Issue: 10
Pages: 3127-37
Publication
First Author: Chatterji B
Year: 2007
Journal: Proteomics
Title: Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers.
Volume: 7
Issue: 21
Pages: 3980-91
Genotype
Symbol: Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Publication  
First Author: Götz R
Year: 2004
Journal: BMC Cancer
Title: BAG-1 haplo-insufficiency impairs lung tumorigenesis.
Volume: 4
Pages: 85
Genotype
Symbol: Bag1/Bag1<+> Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Hosoe S
Year: 1990
Journal: Genomics
Title: Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3.
Volume: 8
Issue: 4
Pages: 634-40
Publication
First Author: Drosten M
Year: 2020
Journal: Cancer Cell
Title: Targeting the MAPK Pathway in KRAS-Driven Tumors.
Volume: 37
Issue: 4
Pages: 543-550
Publication
First Author: Ulaganathan VK
Year: 2015
Journal: Nature
Title: Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.
Volume: 528
Issue: 7583
Pages: 570-4
Publication
First Author: Rapp UR
Year: 2009
Journal: PLoS One
Title: MYC is a metastasis gene for non-small-cell lung cancer.
Volume: 4
Issue: 6
Pages: e6029
Publication
First Author: Müller-Brüsselbach S
Year: 2007
Journal: Int J Oncol
Title: Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene.
Volume: 31
Issue: 3
Pages: 607-11
Publication
First Author: Fedorov LM
Year: 2003
Journal: Cancer Res
Title: Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch.
Volume: 63
Issue: 9
Pages: 2268-77
Genotype
Symbol: Bcl2/Bcl2<+> Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2/Bcl2 Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(H2-K-BCL2)1Josd/? Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Publication  
First Author: Zhao Y
Year: 2016
Journal: Nat Commun
Title: Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Volume: 7
Pages: 12368
Publication
First Author: Maher ER
Year: 1991
Journal: Genomics
Title: Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis.
Volume: 10
Issue: 4
Pages: 957-60
Publication
First Author: Threadgill DS
Year: 1991
Journal: Genomics
Title: Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.
Volume: 11
Issue: 4
Pages: 1143-8
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
Publication
First Author: Ceteci F
Year: 2007
Journal: Cancer Cell
Title: Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer.
Volume: 12
Issue: 2
Pages: 145-59
Publication  
First Author: Pullamsetti SS
Year: 2017
Journal: Sci Transl Med
Title: Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.
Volume: 9
Issue: 416
Publication
First Author: Kogan D
Year: 2018
Journal: J Clin Invest
Title: STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion.
Volume: 128
Issue: 5
Pages: 1867-1872
Publication
First Author: Fedorov LM
Year: 2002
Journal: Cancer Res
Title: Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.
Volume: 62
Issue: 21
Pages: 6297-303
Genotype
Symbol: Bcl2/Bcl2 Tg(H2-K-BCL2)1Josd/? Tg(SFTPC-RAF1-BxB)1Urr/?
Background: involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Araki T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.
Volume: 106
Issue: 12
Pages: 4736-41
Publication
First Author: Oceandy D
Year: 2009
Journal: Circulation
Title: Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
Volume: 120
Issue: 7
Pages: 607-16
Publication
First Author: Asher JH Jr
Year: 1990
Journal: J Med Genet
Title: Mouse and hamster mutants as models for Waardenburg syndromes in humans.
Volume: 27
Issue: 10
Pages: 618-26
Publication
First Author: Sun Y
Year: 2018
Journal: J Immunol
Title: Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection.
Volume: 201
Issue: 9
Pages: 2767-2775
Publication  
First Author: Aonurm-Helm A
Year: 2010
Journal: Brain Res
Title: NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice.
Volume: 1309
Pages: 1-8
Publication
First Author: Jackson AM
Year: 2006
Journal: J Immunol
Title: A role for MAPK in feedback inhibition of Tcrb recombination.
Volume: 176
Issue: 11
Pages: 6824-30
Publication
First Author: Dorard C
Year: 2019
Journal: FEBS J
Title: RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.
Volume: 286
Issue: 12
Pages: 2277-2294
Publication
First Author: Dalin MG
Year: 2014
Journal: Cardiovasc Res
Title: Myocardial KRAS(G12D) expression does not cause cardiomyopathy in mice.
Volume: 101
Issue: 2
Pages: 229-35
Publication  
First Author: Zhou J
Year: 2023
Journal: Int J Mol Sci
Title: The Phosphoproteome of the Rd1 Mouse Retina, a Model of Inherited Photoreceptor Degeneration, Changes after Protein Kinase G Inhibition.
Volume: 24
Issue: 12
Publication
First Author: Seizinger BR
Year: 1988
Journal: Nature
Title: Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma.
Volume: 332
Issue: 6161
Pages: 268-9
Publication
First Author: Matsui T
Year: 2002
Journal: EMBO J
Title: K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development.
Volume: 21
Issue: 5
Pages: 1021-30
Publication
First Author: Zacchia M
Year: 2018
Journal: J Am Soc Nephrol
Title: Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways.
Volume: 29
Issue: 6
Pages: 1720-1730
Publication
First Author: Xi C
Year: 2012
Journal: J Biol Chem
Title: Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.
Volume: 287
Issue: 42
Pages: 35646-35657
Publication  
First Author: Lalley PA
Year: 1989
Journal: Cytogenet Cell Genet
Title: Comparative gene map of mouse Chromosome 9 and human Chromosome 3.
Volume: 51
Pages: 1028-29 (Abstr.)
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Publication
First Author: Reichert N
Year: 2010
Journal: Mol Cell Biol
Title: Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.
Volume: 30
Issue: 12
Pages: 2896-908
Publication  
First Author: Liu MY
Year: 2014
Journal: Neuroscience
Title: Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice.
Volume: 273
Pages: 141-51
Publication
First Author: Zhuang S
Year: 2000
Journal: Mutat Res
Title: Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice.
Volume: 452
Issue: 1
Pages: 19-26
Protein
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true