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Search results 101 to 200 out of 219 for Gga3

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Type Details Score
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
UniProt Feature
Begin: 1
Description: ADP-ribosylation factor-binding protein GGA3
Type: chain
End: 718
Publication
First Author: Kawasaki M
Year: 2005
Journal: Genes Cells
Title: Molecular mechanism of ubiquitin recognition by GGA3 GAT domain.
Volume: 10
Issue: 7
Pages: 639-54
Publication
First Author: Santonico E
Year: 2015
Journal: Oncogene
Title: RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Volume: 34
Issue: 26
Pages: 3377-90
Publication
First Author: Takatsu H
Year: 2002
Journal: Biochem J
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
Volume: 365
Issue: Pt 2
Pages: 369-78
Allele
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3; gene trap RRC067, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Strain
Attribute String: mutant stock, gene trap
Genotype
Symbol: Gga3/Gga3
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gga3/Gga3<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gga1/Gga1 Gga3/Gga3
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gga1/Gga1<+> Gga3/Gga3
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Ouchida R
Year: 2010
Journal: J Immunol
Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Volume: 185
Issue: 1
Pages: 294-301
Publication
First Author: Ouchida R
Year: 2008
Journal: Immunity
Title: A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Volume: 29
Issue: 1
Pages: 33-43
Publication
First Author: Glowacka WK
Year: 2012
Journal: J Biol Chem
Title: LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.
Volume: 287
Issue: 33
Pages: 27691-702
Publication
First Author: Pak Y
Year: 2006
Journal: J Cell Biol
Title: Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination.
Volume: 175
Issue: 4
Pages: 631-45
Protein Domain
Type: Family
Description: The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.This entry represents LAPTM5, which is a lysosomal protein expressed in cells of lymphoid and myeloid origin. LAPTM5 trafficking from the Golgi to the lysosome requires its association with the ubiquitin ligase Nedd4 and the clathrin adaptor GGA3 []. LAPTM5 negatively regulates T and B cell receptor signaling by directly interacting with these receptors and mediating their down-regulation [, ]. It is also a positive regulator of NF-kB and MAPK signaling allowing efficient proinflammatory cytokine production in response to macrophage activation [].
Publication
First Author: Doray B
Year: 2014
Journal: G3 (Bethesda)
Title: Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.
Volume: 4
Issue: 5
Pages: 885-90
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
Publication  
First Author: Albers S
Year: 2014
Journal: Neurobiol Dis
Title: Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice.
Volume: 69
Pages: 32-42
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein Domain
Type: Domain
Description: ADP-ribosylation factor-binding protein GGA3, also known as golgi-localised gamma ear-containing ARF-binding protein 3, plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. GGA3 mediates the ARF-dependent recruitment of clathrin to the TGN []and binds ubiquitinated proteins and membrane cargo molecules [].The GAT domain is a region of homology of ~130 residues, which is found in eukaryotic GGAs (for Golgi-localized, gamma ear-containing ADP ribosylation factor (ARF)-binding proteins) and vertebrate TOMs (for target of myb). The GAT domain is found in its entirety only in GGAs, although, at the C terminus it shares partial sequence similarity with a short region of TOMs. TheGAT domain is found in association with other domains, such as VHS and GAE. The GAT domain of GGAs serves as a molecular anchor of GGA to trans-Golgi network (TGN) membranes via its interaction with the GTP-bound form of a member of the ARF family of small GTPases and can bind specifically to the Rab GTPase effector rabaptin5 and to ubiquitin [, , , ].The GGA-GAT domain possesses an all α-helical structure, composed of four helices arranged in a somewhat unusual topology, which has been called the helical paper clip. The overall structure shows that the GAT domain has an elongated shape, in which the longest helix participates in two small independent subdomains: an N-terminal helix-loop-helix hook and a C-terminal three-helix bundle. The hook subdomain has been shown to be both necessary and sufficient for ARF-GTP binding and Golgi targeting of GGAs. The N-terminal hook subdomain contains a hydrophobic patch, which is found to interact directly with ARF []. It has been proposed that this interaction might stabilise the hook subdomain []. The C-terminal three-helix bundle is involved in the binding with Rabaptin5 and ubiquitin [].This entry represents the GAT domain found in ADP-ribosylation factor-binding protein GGA3.
Publication
First Author: Shiba T
Year: 2002
Journal: Nature
Title: Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Volume: 415
Issue: 6874
Pages: 937-41
Publication
First Author: Bai H
Year: 2004
Journal: J Biol Chem
Title: GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.
Volume: 279
Issue: 17
Pages: 17411-7
Publication
First Author: Nakayama K
Year: 2003
Journal: Cell Struct Funct
Title: The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads.
Volume: 28
Issue: 5
Pages: 431-42
Publication  
First Author: Nakayama K
Year: 2005
Journal: Methods Enzymol
Title: Analysis of Arf interaction with GGAs in vitro and in vivo.
Volume: 404
Pages: 367-77
Protein Domain
Type: Domain
Description: Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport []. Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric GGA (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors [, ].AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180, epsins and auxilin). There are different AP complexes in mammals. AP1 is responsible for the transport of lysosomal hydrolases between the TGN and endosomes []. AP2 associates with the plasma membrane and is responsible for endocytosis []. AP3 is responsible for protein trafficking to lysosomes and other related organelles []. AP4 is less well characterised. AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2-adaptin, mu-2 and sigma-2. Each subunit has a specific function. Adaptins recognise and bind to clathrin through their hinge region (clathrinbox), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. Mu recognises tyrosine-based sorting signals within the cytoplasmic domains of transmembrane cargo proteins []. One function of clathrin and AP2 complex-mediated endocytosis is to regulate the number of GABA(A) receptors available at the cell surface []. GGAs (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. GGAs regulate clathrin-mediated the transport of proteins (such as mannose 6-phosphate receptors) from the TGN to endosomes and lysosomes through interactions with TGN-sorting receptors, sometimes in conjunction with AP-1 [, ]. GGAs bind cargo, membranes, clathrin and accessory factors. GGA1, GGA2 and GGA3 all contain a domain homologous to the ear domain of gamma-adaptin. GGAs are composed of a single polypeptide with four domains: an N-terminal VHS (Vps27p/Hrs/Stam) domain, a GAT (GGA and Tom1) domain, a hinge region, and a C-terminal GAE (gamma-adaptin ear) domain. The VHS domain is responsible for endocytosis and signal transduction, recognising transmembrane cargo through the ACLL sequence in the cytoplasmic domains of sorting receptors []. The GAT domain (also found in Tom1 proteins) interacts with ARF (ADP-ribosylation factor) to regulate membrane trafficking [], and with ubiquitin for receptor sorting []. The hinge region contains a clathrin box for recognition and binding to clathrin, similar to that found in AP adaptins. The GAE domain is similar to the AP gamma-adaptin ear domain, and is responsible for the recruitment of accessory proteins that regulate clathrin-mediated endocytosis [].This entry represents a β-sandwich structural motif found in the appendage (ear) domain of alpha-, beta- and gamma-adaptin from AP clathrin adaptor complexes, and the GAE (gamma-adaptin ear) domain of GGA adaptor proteins. These domains have an immunoglobulin-like β-sandwich fold containing 7 or 8 strands in 2 β-sheets in a Greek key topology [, ]. Although these domains share a similar fold, there is little sequence identity between the alpha/beta-adaptins and gamma-adaptin/GAE.
Publication
First Author: Shiba T
Year: 2003
Journal: Nat Struct Biol
Title: Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.
Volume: 10
Issue: 5
Pages: 386-93
Publication
First Author: Collins BM
Year: 2003
Journal: Dev Cell
Title: The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs.
Volume: 4
Issue: 3
Pages: 321-32
Publication
First Author: Zhu G
Year: 2004
Journal: EMBO J
Title: Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5.
Volume: 23
Issue: 20
Pages: 3909-17
Publication
First Author: Lui WW
Year: 2003
Journal: Mol Biol Cell
Title: Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.
Volume: 14
Issue: 6
Pages: 2385-98
Publication
First Author: Nogi T
Year: 2002
Journal: Nat Struct Biol
Title: Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.
Volume: 9
Issue: 7
Pages: 527-31
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
Protein
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
Publication
First Author: Haucke V
Year: 2000
Journal: EMBO J
Title: Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.
Volume: 19
Issue: 22
Pages: 6011-9
Publication
First Author: Touz MC
Year: 2004
Journal: Mol Biol Cell
Title: Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi-like organelle to peripheral vacuoles in the primitive eukaryote Giardia lamblia.
Volume: 15
Issue: 7
Pages: 3053-60
Publication
First Author: Conner SD
Year: 2003
Journal: J Cell Biol
Title: Differential requirements for AP-2 in clathrin-mediated endocytosis.
Volume: 162
Issue: 5
Pages: 773-9
Publication
First Author: Gupta SN
Year: 2006
Journal: Eur J Cell Biol
Title: Re-routing of the invariant chain to the direct sorting pathway by introduction of an AP3-binding motif from LIMP II.
Volume: 85
Issue: 6
Pages: 457-67
Publication
First Author: Kanematsu T
Year: 2007
Journal: J Neurochem
Title: Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.
Volume: 101
Issue: 4
Pages: 898-905
Protein
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: false