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Search results 101 to 106 out of 106 for Cep55

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Type Details Score
Protein Domain
IPR039339 | Tex14
Type: Family
Description: TEX14 is an inactive serine/threonine-protein kinase because the active site aspartic acid residue has been replaced. It localizes to germ cell intercellular bridges during spermatogenesis. In germ cell cytokinesis a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel forms, unlike in somatic cells. This bridge does not form in TEX14 deficient mice and male mice are sterile []; female knockout mice are fertile []. TEX14 binds to CEP55, which is a stable component of the intercellular bridge, via a GPPX3Y motif and preventing proteins with a similar motif (such as ALIX and TSG101) from binding to CEP55 []. During mitosis, TEX14 is recruited to kinetochores by Plk1 and without TEX14, kinetochores are unable to bind other essential components leading to chromosome instability. Phosphorylation of TEX14 by Plk1 leads to its degradation, which is essential for metaphase-to-anaphase transition and chromosome segregation []. TEX14 contains ankyrin repeat-containing domains and a protein kinase domain.
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Publication
20616062 | J:320142
First Author: Morita E
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
Volume: 107
Issue: 29
Pages: 12889-94
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Protein
I6L9F2
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
B2KGK9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
Q7M6U3
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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Protein
A0A571BD42
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
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