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Search results 601 to 686 out of 686 for Btk

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0.044s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein
P29387
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
Q9DAS9
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Protein
Q9CXP8
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Protein
P63213
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Protein
P63216
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
P50153
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
Q80SZ7
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Protein
Q61016
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Protein
P63078
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Protein
P61953
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: false
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Publication
21460216 | -
First Author: Dai Y
Year: 2011
Journal: J Biol Chem
Title: Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Volume: 286
Issue: 22
Pages: 19905-16
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Publication
10339589 | J:55122
First Author: Yamadori T
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
Volume: 96
Issue: 11
Pages: 6341-6
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Publication
8777721 | J:31230
First Author: Liao XC
Year: 1995
Journal: Immunity
Title: Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Volume: 3
Issue: 6
Pages: 757-69
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Publication
15304502 | J:119327
First Author: Shao Y
Year: 2004
Journal: J Biol Chem
Title: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
Volume: 279
Issue: 42
Pages: 43646-53
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Publication
15539154 | J:93888
First Author: Stork B
Year: 2004
Journal: Immunity
Title: Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Volume: 21
Issue: 5
Pages: 681-91
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Publication
25646432 | J:220007
First Author: Feng M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.
Volume: 112
Issue: 7
Pages: 2145-50
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Publication
26932182 | J:266713
 
First Author: Guo M
Year: 2016
Journal: Sci Rep
Title: Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption.
Volume: 6
Pages: 22378
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Publication
26851222 | J:299348
First Author: Guo B
Year: 2016
Journal: J Immunol
Title: RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen Receptors.
Volume: 196
Issue: 6
Pages: 2583-90
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Publication
30712845 | J:271176
First Author: Yin S
Year: 2019
Journal: Cancer Cell
Title: A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.
Volume: 35
Issue: 2
Pages: 283-296.e5
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Publication
28755662 | J:259881
   
First Author: Shaheen S
Year: 2017
Journal: Elife
Title: Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.
Volume: 6
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Publication
7829087 | J:20150
First Author: Janis EM
Year: 1994
Journal: Genomics
Title: Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Volume: 23
Issue: 1
Pages: 269-71
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Publication
18981111 | J:140944
First Author: Nixon JC
Year: 2008
Journal: J Immunol
Title: Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells.
Volume: 181
Issue: 10
Pages: 6913-22
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Publication
10556826 | J:243546
First Author: Su YW
Year: 1999
Journal: Eur J Immunol
Title: Interaction of SLP adaptors with the SH2 domain of Tec family kinases.
Volume: 29
Issue: 11
Pages: 3702-11
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Publication
30318148 | J:267413
First Author: Xu X
Year: 2018
Journal: Cell
Title: Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response.
Volume: 175
Issue: 5
Pages: 1336-1351.e17
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Protein Domain
IPR037776 | RASAL_RasGAP
Type: Domain
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].This entry represents the RasGAP domain of RASAL. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASA4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i). CAPRI and RASAL differ in that CAPRI is an amplitude sensor while RASAL senses calcium oscillations [, ]. This difference between them resides not in their C2 domains, but in their PH domains leading to speculation that this might reflect an association with either phosphoinositides and/or proteins [].
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Genotype
Genotype
Symbol: Blnk/Blnk Btk/? Tg(CD19-BTK*K430R)XK24Rwhe/?
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1925616 | Gng13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95781 | Gnb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109165 | Gngt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95785 | Gnb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101848 | Gnb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62881
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q61011
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
Q9JMF3
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: false
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Protein
Q61012
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
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Protein
P62874
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Publication
32484802 | J:297441
First Author: Dispenza MC
Year: 2020
Journal: J Clin Invest
Title: Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.
Volume: 130
Issue: 9
Pages: 4759-4770
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Publication
35313337 | J:326031
First Author: Leberzammer J
Year: 2022
Journal: Blood
Title: Targeting platelet-derived CXCL12 impedes arterial thrombosis.
Volume: 139
Issue: 17
Pages: 2691-2705
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Publication
28474779 | J:276807
First Author: Sacco A
Year: 2017
Journal: Am J Hematol
Title: A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation.
Volume: 92
Issue: 8
Pages: E138-E145
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Publication
29326436 | J:261034
First Author: Patrussi L
Year: 2018
Journal: Oncogene
Title: p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.
Volume: 37
Issue: 11
Pages: 1534-1550
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Publication
24812669 | J:212913
First Author: Tang CH
Year: 2014
Journal: J Clin Invest
Title: Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Volume: 124
Issue: 6
Pages: 2585-98
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Publication
28751718 | J:247687
First Author: Knittel G
Year: 2017
Journal: Nat Commun
Title: Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia.
Volume: 8
Issue: 1
Pages: 153
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Publication
20400514 | J:164469
First Author: Daniel JL
Year: 2010
Journal: J Biol Chem
Title: Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.
Volume: 285
Issue: 23
Pages: 17282-91
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Publication
10556550 | J:58472
First Author: Corcoran LM
Year: 1999
Journal: J Immunol Methods
Title: Generation of B lymphoma cell lines from knockout mice by transformation in vivo with an Emu-myc transgene.
Volume: 228
Issue: 1-2
Pages: 131-8
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Publication
19494314 | J:149286
First Author: Fehrenbach K
Year: 2009
Journal: J Immunol
Title: Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta.
Volume: 182
Issue: 12
Pages: 7897-905
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Publication
24193737 | J:211506
First Author: Chandra R
Year: 2014
Journal: J Leukoc Biol
Title: Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis.
Volume: 95
Issue: 3
Pages: 497-507
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Publication
32684632 | J:296461
First Author: Parting O
Year: 2020
Journal: Leukemia
Title: Therapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia.
Volume: 34
Issue: 10
Pages: 2635-2647
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Publication
11207264 | J:126693
First Author: Li X
Year: 2001
Journal: J Immunol
Title: Antigen receptor proximal signaling in splenic B-2 cell subsets.
Volume: 166
Issue: 5
Pages: 3122-9
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Publication
31611261 | J:282194
First Author: Lin Q
Year: 2019
Journal: J Immunol
Title: RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling.
Volume: 203
Issue: 11
Pages: 2862-2871
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Publication
25271622 | J:217616
First Author: Dubovsky JA
Year: 2014
Journal: J Clin Invest
Title: Ibrutinib treatment ameliorates murine chronic graft-versus-host disease.
Volume: 124
Issue: 11
Pages: 4867-76
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Publication
26845758 | J:246182
First Author: Win S
Year: 2016
Journal: Hepatology
Title: c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
Volume: 63
Issue: 6
Pages: 1987-2003
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Publication
31487267 | J:284270
First Author: Win S
Year: 2019
Journal: J Clin Invest
Title: Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
Volume: 129
Issue: 12
Pages: 5278-5293
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Publication
33831782 | J:305528
 
First Author: Vogel S
Year: 2021
Journal: Biochem Biophys Res Commun
Title: NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice.
Volume: 555
Pages: 196-201
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Publication
33639170 | J:304820
   
First Author: Whillock AL
Year: 2021
Journal: J Biol Chem
Title: TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells.
Pages: 100465
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Publication
32016488 | J:311707
First Author: Li N
Year: 2020
Journal: Cell Mol Life Sci
Title: CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling.
Volume: 77
Issue: 21
Pages: 4379-4395
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Publication
29615403 | J:264755
First Author: Kuo PY
Year: 2018
Journal: Blood
Title: SOX11 augments BCR signaling to drive MCL-like tumor development.
Volume: 131
Issue: 20
Pages: 2247-2255
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Publication
22084235 | J:181388
First Author: Li W
Year: 2012
Journal: J Biol Chem
Title: Core fucosylation of μ heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
Volume: 287
Issue: 4
Pages: 2500-8
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Publication
22180443 | J:181728
First Author: Ponader S
Year: 2012
Journal: Blood
Title: The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.
Volume: 119
Issue: 5
Pages: 1182-9
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Publication
11606584 | J:73459
First Author: Rodriguez R
Year: 2001
Journal: J Biol Chem
Title: Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
Volume: 276
Issue: 51
Pages: 47982-92
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Publication
7515712 | J:18757
First Author: Matsuda T
Year: 1994
Journal: Blood
Title: Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor.
Volume: 83
Issue: 12
Pages: 3457-61
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Publication
7934162 | J:21143
First Author: Sato K
Year: 1994
Journal: Leukemia
Title: Molecular cloning and analysis of the human Tec protein-tyrosine kinase.
Volume: 8
Issue: 10
Pages: 1663-72
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Publication
7536925 | J:24355
First Author: Alexandropoulos K
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
Volume: 92
Issue: 8
Pages: 3110-4
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Publication
8632917 | J:31642
First Author: Ohta Y
Year: 1996
Journal: Oncogene
Title: Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.
Volume: 12
Issue: 4
Pages: 937-42
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Publication
14635049 | J:90001
First Author: Wilson EL
Year: 2003
Journal: Eur J Immunol
Title: A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107.
Volume: 33
Issue: 12
Pages: 3398-408
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Publication
15383560 | J:93730
First Author: Kitaura J
Year: 2004
Journal: J Immunol
Title: Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.
Volume: 173
Issue: 7
Pages: 4317-23
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Publication
10521450 | J:115128
First Author: Craxton A
Year: 1999
Journal: J Biol Chem
Title: Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.
Volume: 274
Issue: 43
Pages: 30644-50
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Publication
19214191 | J:146814
First Author: Schmidt C
Year: 2009
Journal: EMBO J
Title: Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.
Volume: 28
Issue: 6
Pages: 711-24
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Publication
25634698 | J:220331
First Author: Sakuma C
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages.
Volume: 458
Issue: 1
Pages: 28-33
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Publication
25838351 | J:222632
First Author: Hing ZA
Year: 2015
Journal: Blood
Title: Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Volume: 125
Issue: 20
Pages: 3128-32
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Publication
28202459 | J:241537
First Author: Pandey S
Year: 2017
Journal: Blood
Title: IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma.
Volume: 129
Issue: 18
Pages: 2507-2518
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Publication
27904138 | J:241799
First Author: Yu J
Year: 2017
Journal: Leukemia
Title: Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib.
Volume: 31
Issue: 6
Pages: 1333-1339
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Publication
26450454 | J:259732
First Author: Sochalska M
Year: 2016
Journal: Cell Death Differ
Title: Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Volume: 23
Issue: 4
Pages: 628-39
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Publication
30700840 | J:273244
First Author: Nguyen PH
Year: 2019
Journal: Leukemia
Title: New roles for B cell receptor associated kinases: when the B cell is not the target.
Volume: 33
Issue: 3
Pages: 576-587
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Publication
31365830 | J:298808
First Author: Keshari S
Year: 2019
Journal: FASEB J
Title: IL-6/p-BTK/p-ERK signaling mediates calcium phosphate-induced pruritus.
Volume: 33
Issue: 11
Pages: 12036-12046
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Publication
37979447 | J:343487
 
First Author: Liu C
Year: 2023
Journal: Redox Biol
Title: CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Volume: 68
Pages: 102960
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Publication
34156977 | J:327664
 
First Author: Pará C
Year: 2021
Journal: JCI Insight
Title: Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission.
Volume: 6
Issue: 15
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Publication
19157556 | J:148300
First Author: Tsukamoto Y
Year: 2009
Journal: Mol Immunol
Title: Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
Volume: 46
Issue: 7
Pages: 1278-88
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Publication
34331779 | J:346111
First Author: Win S
Year: 2021
Journal: Hepatology
Title: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
Volume: 74
Issue: 6
Pages: 3127-3145
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Publication
17947660 | -
First Author: Cao L
Year: 2007
Journal: J Immunol
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Volume: 179
Issue: 9
Pages: 5864-76
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Protein
P42682
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q0VBP6
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
B2RQ20
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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