This entry includes SMPD2 from animals, Isc1/Css1 from yeasts and sphingomyelinase C (also known as sph) from bacteria.Neutral sphingomyelinase (nSMase) sphingomyelin phosphodiesterase SMPD2 hydrolyzes sphingomyelin to phosphocholine and ceramide. SMPD2, differently to nSMase SMPD3, which is prominent in brain, is ubiquitously expressed []. Both are involved in vesicle budding from the plasma membrane [].Budding yeast Isc1 is inositol phosphosphingolipid phospholipase C that localizes to mitochondria in the post-diauxic phase of yeast growth []. Fission yeast Isc1 homologue, Css1, localizes to the entire plasma membrane and secretory pathway [].
