Prp3 (also known as PRP3) participates in pre-mRNA splicing []. It may play a role in the assembly of the U4/U5/U6 tri-snRNP complex []. Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18). RP leads to degeneration of retinal photoreceptor cells [, , ]. In Arabidposis thaliana, protein RDM16 acts as a pre-mRNA splicing factor and functions in RNA-directed DNA methylation by influencing Pol V transcript levels [].
