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Search results 801 to 900 out of 1034 for Rel

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Type Details Score
Publication
3118464 | -
First Author: Steward R
Year: 1987
Journal: Science
Title: Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel.
Volume: 238
Issue: 4827
Pages: 692-4
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Publication
8242747 | -
First Author: Ip YT
Year: 1993
Journal: Cell
Title: Dif, a dorsal-related gene that mediates an immune response in Drosophila.
Volume: 75
Issue: 4
Pages: 753-63
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Protein Domain
IPR011363 | Dif
Type: Family
Description: The Dorsal morphogen directs formation of the Drosophila dorsoventral axis by both activating and repressing transcription. It contains an N-terminal Rel homology domain (RHD), which is responsible for DNA binding and regulated nuclear import, and a C-terminal domain (CTD) that contains activation and repression motifs []. In wild-type embryos, the dorsal protein is found in the cytoplasm during cleavage. After the nuclei migrate to the periphery of the embryo, a ventral-to-dorsal gradient of nuclear dorsal protein is established [].Dorsal-related immunity factor Dif does not appear to participate in dorsoventral patterning, but instead mediates an immune response in Drosophila larvae. Dif is normally localised in the cytoplasm of the larval fat body, but quickly accumulates in the nucleus upon bacterial infection or injury. Once in the nucleus, Dif binds to kappa B-like sequence motifs present in promoter regions of immunity genes [].
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Publication
9388475 | J:44350
First Author: Pan S
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.
Volume: 240
Issue: 2
Pages: 314-23
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Publication
9548511 | J:44265
First Author: Tanabe S
Year: 1997
Journal: J Immunol
Title: Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.
Volume: 159
Issue: 11
Pages: 5671-9
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Publication
9405619 | J:45073
First Author: Simeonidis S
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Cloning and functional characterization of mouse IkappaBepsilon.
Volume: 94
Issue: 26
Pages: 14372-7
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Publication
12162804 | J:77925
First Author: Jin R
Year: 2002
Journal: DNA Cell Biol
Title: Regulation of the gadd45beta promoter by NF-kappaB.
Volume: 21
Issue: 7
Pages: 491-503
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Publication
21734074 | J:179171
First Author: Ali S
Year: 2011
Journal: J Immunol
Title: The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.
Volume: 187
Issue: 4
Pages: 1609-16
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Publication
15790681 | J:97353
First Author: Bettelli E
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
Volume: 102
Issue: 14
Pages: 5138-43
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Publication
7650004 | J:28305
First Author: Ho SN
Year: 1995
Journal: J Biol Chem
Title: NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.
Volume: 270
Issue: 34
Pages: 19898-907
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Publication
11278367 | J:87345
First Author: Plyte S
Year: 2001
Journal: J Biol Chem
Title: Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain.
Volume: 276
Issue: 17
Pages: 14350-8
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Publication
8281153 | J:36279
First Author: Deloukas P
Year: 1993
Journal: Hum Mol Genet
Title: Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.
Volume: 2
Issue: 11
Pages: 1895-900
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Publication
10702415 | J:60742
First Author: Rosenfeld ME
Year: 2000
Journal: Am J Pathol
Title: Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.
Volume: 156
Issue: 3
Pages: 997-1007
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Publication
24550492 | J:207405
First Author: Silva A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: NF-κB signaling mediates homeostatic maturation of new T cells.
Volume: 111
Issue: 9
Pages: E846-55
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Publication
10878354 | J:63191
First Author: Yamada T
Year: 2000
Journal: J Immunol
Title: Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase.
Volume: 165
Issue: 2
Pages: 804-12
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Publication
8035813 | J:106465
First Author: Liou HC
Year: 1994
Journal: Mol Cell Biol
Title: Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.
Volume: 14
Issue: 8
Pages: 5349-59
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Publication
33228790 | J:313916
First Author: Takadera M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes.
Volume: 8
Issue: 1
Pages: 203
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Publication
33932404 | J:316229
 
First Author: Tapryal N
Year: 2021
Journal: J Biol Chem
Title: Intrapulmonary administration of purified NEIL2 abrogates NF-κB-mediated inflammation.
Volume: 296
Pages: 100723
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Publication
24302727 | J:318623
First Author: Vogel CF
Year: 2014
Journal: J Biol Chem
Title: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.
Volume: 289
Issue: 3
Pages: 1866-75
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Publication
28381543 | J:242297
First Author: Redd PS
Year: 2017
Journal: Cancer Res
Title: SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.
Volume: 77
Issue: 11
Pages: 2834-2843
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Publication
16260608 | J:102395
First Author: Dai YS
Year: 2005
Journal: Mol Cell Biol
Title: The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.
Volume: 25
Issue: 22
Pages: 9936-48
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Publication
7513199 | J:17896
First Author: Dunn SM
Year: 1994
Journal: Blood
Title: Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter.
Volume: 83
Issue: 9
Pages: 2469-79
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Publication
10919279 | J:65563
First Author: Yao GQ
Year: 2000
Journal: Endocrinology
Title: Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts.
Volume: 141
Issue: 8
Pages: 2914-22
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Publication
7739550 | J:24519
First Author: Masuda ES
Year: 1995
Journal: Mol Cell Biol
Title: NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.
Volume: 15
Issue: 5
Pages: 2697-706
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Publication
7565674 | J:28788
First Author: Murphy TL
Year: 1995
Journal: Mol Cell Biol
Title: Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.
Volume: 15
Issue: 10
Pages: 5258-67
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Publication
8887559 | J:35402
First Author: Wu M
Year: 1996
Journal: EMBO J
Title: Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
Volume: 15
Issue: 17
Pages: 4682-90
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Publication
9143705 | J:40177
 
First Author: Rao A
Year: 1997
Journal: Annu Rev Immunol
Title: Transcription factors of the NFAT family: regulation and function.
Volume: 15
Pages: 707-47
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Publication
23630580 | J:200629
First Author: Zhao W
Year: 2013
Journal: PLoS One
Title: SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function.
Volume: 8
Issue: 4
Pages: e61123
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Publication
28842479 | J:246728
First Author: Johnson ZI
Year: 2017
Journal: J Biol Chem
Title: TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Volume: 292
Issue: 42
Pages: 17561-17575
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Publication
34695199 | J:344043
First Author: Kogure Y
Year: 2022
Journal: Blood
Title: Whole-genome landscape of adult T-cell leukemia/lymphoma.
Volume: 139
Issue: 7
Pages: 967-982
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Publication
12750314 | J:84138
First Author: Bushdid PB
Year: 2003
Journal: Circ Res
Title: NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.
Volume: 92
Issue: 12
Pages: 1305-13
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Publication
17693409 | J:126797
First Author: Wu H
Year: 2007
Journal: J Biol Chem
Title: Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.
Volume: 282
Issue: 42
Pages: 30673-9
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Publication
32778883 | J:320917
First Author: Rivaud MR
Year: 2020
Journal: Europace
Title: Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Volume: 22
Issue: 10
Pages: 1579-1589
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Publication
10925280 | J:63747
First Author: Zuklys S
Year: 2000
Journal: J Immunol
Title: Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Volume: 165
Issue: 4
Pages: 1976-83
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Publication
17573907 | J:148571
First Author: Bourteele S
Year: 2007
Journal: Cell Microbiol
Title: Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein.
Volume: 9
Issue: 9
Pages: 2202-17
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Publication
9058787 | J:107546
First Author: DeKoning J
Year: 1997
Journal: J Immunol
Title: Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.
Volume: 158
Issue: 6
Pages: 2558-66
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Publication
25630465 | J:229270
First Author: Dietz L
Year: 2015
Journal: Eur J Immunol
Title: NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms.
Volume: 45
Issue: 5
Pages: 1377-89
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Publication
17982070 | J:153863
First Author: Qin J
Year: 2007
Journal: J Immunol
Title: Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs.
Volume: 179
Issue: 10
Pages: 6799-807
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Publication
18799149 | J:139649
First Author: Akiyama T
Year: 2008
Journal: Immunity
Title: The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Volume: 29
Issue: 3
Pages: 423-37
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Publication
11932402 | J:126282
First Author: Oldstone MB
Year: 2002
Journal: J Virol
Title: Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.
Volume: 76
Issue: 9
Pages: 4357-63
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Publication
22425250 | J:187054
First Author: Roberts NA
Year: 2012
Journal: Immunity
Title: Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.
Volume: 36
Issue: 3
Pages: 427-37
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Publication
37045811 | J:334816
First Author: Lucas B
Year: 2023
Journal: Nat Commun
Title: Embryonic keratin19(+) progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Volume: 14
Issue: 1
Pages: 2066
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Publication
16554754 | J:109139
First Author: Arron JR
Year: 2006
Journal: Nature
Title: NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Volume: 441
Issue: 7093
Pages: 595-600
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Publication
14595020 | J:86543
First Author: Berland R
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Normal B-1a cell development requires B cell-intrinsic NFATc1 activity.
Volume: 100
Issue: 23
Pages: 13459-64
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Publication
12787506 | J:83744
First Author: Graef IA
Year: 2003
Journal: Cell
Title: Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
Volume: 113
Issue: 5
Pages: 657-70
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Publication
24510964 | J:209925
First Author: White AJ
Year: 2014
Journal: J Immunol
Title: An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Volume: 192
Issue: 6
Pages: 2659-66
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Publication
18354221 | J:133370
First Author: Castiglioni P
Year: 2008
Journal: J Immunol
Title: Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells.
Volume: 180
Issue: 7
Pages: 4956-64
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Publication
21900177 | J:179324
First Author: O'Sullivan BJ
Year: 2011
Journal: J Immunol
Title: Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.
Volume: 187
Issue: 8
Pages: 4018-30
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Publication
24656046 | J:209992
First Author: Jin J
Year: 2014
Journal: Immunity
Title: Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.
Volume: 40
Issue: 3
Pages: 342-54
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Publication
17984055 | J:127244
First Author: Li J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice.
Volume: 104
Issue: 46
Pages: 18175-80
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Publication
9209490 | J:40940
First Author: Naspetti M
Year: 1997
Journal: Eur J Immunol
Title: Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells.
Volume: 27
Issue: 6
Pages: 1392-7
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Genotype
Genotype
Symbol: Nfatc2/Nfatc2 Nfatc3/Nfatc3 Nfatc4/Nfatc4
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Publication
7561058 | J:28785
First Author: Ohmori Y
Year: 1995
Journal: J Immunol
Title: Two structurally distinct kappa B sequence motifs cooperatively control LPS-induced KC gene transcription in mouse macrophages.
Volume: 155
Issue: 7
Pages: 3593-600
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Publication
7969179 | J:21614
First Author: Grumont RJ
Year: 1994
Journal: Mol Cell Biol
Title: Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription.
Volume: 14
Issue: 12
Pages: 8460-70
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Publication
34010296 | J:307264
First Author: Helmer RA
Year: 2021
Journal: PLoS One
Title: Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis.
Volume: 16
Issue: 5
Pages: e0251132
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Publication
22403241 | J:212523
First Author: Liu Q
Year: 2012
Journal: Circ Res
Title: Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling.
Volume: 110
Issue: 8
Pages: 1077-86
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Publication
11133232 | J:102613
First Author: Dawn B
Year: 2001
Journal: J Mol Cell Cardiol
Title: Cardiac-specific abrogation of NF- kappa B activation in mice by transdominant expression of a mutant I kappa B alpha.
Volume: 33
Issue: 1
Pages: 161-73
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Publication
7963540 | J:21378
First Author: Tebo JM
Year: 1994
Journal: J Immunol
Title: Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Volume: 153
Issue: 10
Pages: 4713-20
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Publication
9426183 | -
First Author: Piette J
Year: 1997
Journal: Biol Chem
Title: Multiple redox regulation in NF-kappaB transcription factor activation.
Volume: 378
Issue: 11
Pages: 1237-45
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Publication
17431096 | -
First Author: Neumann M
Year: 2007
Journal: FASEB J
Title: Beyond IkappaBs: alternative regulation of NF-kappaB activity.
Volume: 21
Issue: 11
Pages: 2642-54
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Protein Domain
IPR042845 | RHD-n_c-Rel
Type: Domain
Description: NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel) [, ]. c-Rel plays an important role in B cell proliferation and survival [].Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains. This entry represents the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD) [, ].
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Publication
19414766 | J:148241
First Author: Becker M
Year: 2009
Journal: J Immunol
Title: Impaired mast cell-driven immune responses in mice lacking the transcription factor NFATc2.
Volume: 182
Issue: 10
Pages: 6136-42
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Publication
18505785 | J:138422
First Author: Guo F
Year: 2008
Journal: Blood
Title: Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.
Volume: 112
Issue: 3
Pages: 551-9
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Publication
23962643 | J:225391
 
First Author: Nicholson CK
Year: 2013
Journal: J Mol Cell Cardiol
Title: Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
Volume: 64
Pages: 1-10
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Publication
24316970 | J:207911
First Author: Xiu Y
Year: 2014
Journal: J Clin Invest
Title: Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
Volume: 124
Issue: 1
Pages: 297-310
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Publication
28894104 | J:247562
First Author: Klein-Hessling S
Year: 2017
Journal: Nat Commun
Title: NFATc1 controls the cytotoxicity of CD8+ T cells.
Volume: 8
Issue: 1
Pages: 511
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Publication
22991461 | J:190104
First Author: Vaeth M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Volume: 109
Issue: 40
Pages: 16258-63
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Publication
12810684 | J:120660
First Author: Sivakumar V
Year: 2003
Journal: J Exp Med
Title: Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development.
Volume: 197
Issue: 12
Pages: 1613-21
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Publication
12505990 | J:81255
First Author: Yilmaz ZB
Year: 2003
Journal: EMBO J
Title: RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF.
Volume: 22
Issue: 1
Pages: 121-30
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Publication
15057750 | J:93475
First Author: Gerth AJ
Year: 2004
Journal: Gastroenterology
Title: An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells.
Volume: 126
Issue: 4
Pages: 1115-21
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Publication
15728489 | J:97710
First Author: Rodriguez-Galán MC
Year: 2005
Journal: J Immunol
Title: Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
Volume: 174
Issue: 5
Pages: 2796-804
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Publication
28082356 | J:240695
First Author: Diamanti MA
Year: 2017
Journal: J Exp Med
Title: IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Volume: 214
Issue: 2
Pages: 423-437
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Publication
24882009 | J:211784
First Author: Göktuna SI
Year: 2014
Journal: Cell Rep
Title: IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Volume: 7
Issue: 6
Pages: 1914-25
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Publication
16810633 | J:115794
First Author: Le Bon A
Year: 2006
Journal: Eur J Immunol
Title: A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming.
Volume: 36
Issue: 8
Pages: 2085-93
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Publication
24324158 | J:206133
First Author: Jenkinson SR
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Volume: 110
Issue: 52
Pages: 21107-12
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Publication
25520665 | J:310509
 
First Author: Mamidi R
Year: 2014
Journal: Front Physiol
Title: Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.
Volume: 5
Pages: 461
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Publication
26913007 | J:312086
 
First Author: Mamidi R
Year: 2016
Journal: Front Physiol
Title: Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent Activation.
Volume: 7
Pages: 38
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Protein Domain
IPR035897 | Toll_tir_struct_dom_sf
Type: Homologous_superfamily
Description: Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor (IL-1R) superfamily areboth involved in innate antibacterial and antifungalimmunity in insects as well as in mammals. These receptors share a conserved cytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1R homologous region (TIR). The similarity between TLRs and IL-1Rs is not restricted to sequence homology since these proteins also share a similar signalling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase []. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain [, , ]. Besides the mammalian and Drosophila proteins, a TIR domain is also found in a number of plant cytoplasmic proteins implicated in host defense [].Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signalling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal element [].Resolution of the crystal structures of the TIR domains of human Toll-like receptors 1 and 2 has shown that they contain a central five-stranded parallel β-sheet that is surrounded by a total of five helices on both sides, with connecting loop structures []. The loop regions appear to play an important role in mediating the specificity of protein-proteininteractions [, ].
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Publication
29246443 | J:259282
First Author: Man K
Year: 2017
Journal: Immunity
Title: Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.
Volume: 47
Issue: 6
Pages: 1129-1141.e5
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Publication
16896157 | J:140442
First Author: Gray DH
Year: 2006
Journal: Blood
Title: Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.
Volume: 108
Issue: 12
Pages: 3777-85
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Publication
34289356 | J:323836
First Author: Chappaz S
Year: 2021
Journal: Cell Rep
Title: Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells.
Volume: 36
Issue: 3
Pages: 109430
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Publication
30170810 | J:275850
First Author: Hou Y
Year: 2018
Journal: Immunity
Title: Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.
Volume: 49
Issue: 3
Pages: 490-503.e4
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Publication
29030115 | J:259234
First Author: Vaeth M
Year: 2017
Journal: Immunity
Title: Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Volume: 47
Issue: 4
Pages: 664-679.e6
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Publication
25105474 | J:274172
 
First Author: Pereira RM
Year: 2014
Journal: Nat Commun
Title: Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Volume: 5
Pages: 4540
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Publication
21469133 | J:175402
First Author: Ripen AM
Year: 2011
Journal: Eur J Immunol
Title: Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t.
Volume: 41
Issue: 5
Pages: 1278-87
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Publication
28348230 | J:242023
First Author: Briseño CG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Volume: 114
Issue: 15
Pages: 3957-3962
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Publication
24892805 | J:213803
First Author: Zhang H
Year: 2014
Journal: J Clin Invest
Title: NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.
Volume: 124
Issue: 7
Pages: 3200-14
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Publication
29485182 | J:263501
First Author: Andreas N
Year: 2018
Journal: Eur J Immunol
Title: A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.
Volume: 48
Issue: 6
Pages: 923-936
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Publication
31387996 | J:279496
First Author: Lee HH
Year: 2019
Journal: Nat Commun
Title: TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging.
Volume: 10
Issue: 1
Pages: 3536
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Publication
20200955 | J:183365
First Author: Otero JE
Year: 2010
Journal: J Bone Miner Res
Title: IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis.
Volume: 25
Issue: 6
Pages: 1282-94
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Publication
30018073 | J:266034
First Author: Huang T
Year: 2018
Journal: J Exp Med
Title: CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis.
Volume: 215
Issue: 8
Pages: 1999-2017
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Publication
29395922 | -
First Author: Essuman K
Year: 2018
Journal: Curr Biol
Title: TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.
Volume: 28
Issue: 3
Pages: 421-430.e4
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Publication
34184985 | -
   
First Author: Loring HS
Year: 2021
Journal: Elife
Title: A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Volume: 10
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Protein Domain
IPR000157 | TIR_dom
Type: Domain
Description: This entry represents the Toll/interleukin-1 receptor (TIR) domain, which is the conserved cytoplasmic domain of approximately 200 amino acids, found in Toll-like receptors (TLRs) and their adaptors. Proteins containing this domain can also be found in plants, where they mediate disease resistance [], and in bacteria, where they have been associated with virulence. Interestingly, the TIR domains from proteins present in all three major domains of life have been shown to cleave nicotinamide adenine dinucleotide (NAD+). In plants, TIR domains require self-association interfaces and a putative catalytic glutamic acid that is conserved in both bacterial TIR NAD+-cleaving enzymes (NADases) and the mammalian SARM1 (sterile alpha and TIR motif containing 1) NADase for cell death induction and NAD+ cleavage activity [, ]. It has been suggested that the primordial function of the TIR domain is the enzymatic cleavage of NAD+ and that the scaffolding function, which is best characterised in mammalian TIR domains involved in innate immunity, may be a more recent evolutionary adaptation [].Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor (IL-1R) superfamily are both involved in innate antibacterial and antifungalimmunity in insects as well as in mammals. These receptors share a conserved cytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1R homologous region (TIR). The similarity between TLRs and IL-1Rs is not restricted to sequence homology since these proteins also share a similar signalling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase []. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain [, , ]. Besides the mammalian and Drosophila proteins, a TIR domain is also found in a number of plant cytoplasmic proteins implicated in host defense [].Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signalling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal element [].Resolution of the crystal structures of the TIR domains of human Toll-like receptors 1 and 2 has shown that they contain a central five-stranded parallel β-sheet that is surrounded by a total of five helices on both sides, with connecting loop structures []. The loop regions appear to play an important role in mediating the specificity of protein-protein interactions [, ].
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Protein
Q80VH0
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
Q9EQ32
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
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Protein
Q80UF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Publication
10231569 | J:54928
First Author: Takeuchi O
Year: 1999
Journal: Gene
Title: TLR6: A novel member of an expanding toll-like receptor family.
Volume: 231
Issue: 1-2
Pages: 59-65
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Protein
Q8BJQ4
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q99JY1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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