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Search results 101 to 105 out of 105 for Rab3gap1

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0.017s

Type

Details

Score

Protein Domain

IPR045698 | Rab3GAP1_C

Type:

Domain

Description:

This entry represents the C-terminal domain found in the Rab3 GTPase-activating protein catalytic subunit (Rab3GAP1) predominantly in animals.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].

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Protein

Q8BYZ6

Organism:	Mus musculus/domesticus
Length:	183
Fragment?:	true

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Protein

Q3UEY3

Organism:	Mus musculus/domesticus
Length:	468
Fragment?:	true

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Publication

30856165 | J:273099

First Author:	Handley MT
Year:	2019
Journal:	PLoS Genet
Title:	ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.
Volume:	15
Issue:	3
Pages:	e1007605

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Publication

25476608 | J:315009

First Author:	Park AK
Year:	2014
Journal:	BMC Genet
Title:	Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice.
Volume:	15

Pages:	135

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