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Search results 1 to 100 out of 277 for Rai1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Domain
Description: Yeast RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z (DXO). They have both decapping and 5'-3' exoribonuclease activity and are a component of the mRNA 5'-end capping quality control mechanism [, ]. RAI1 is a single-copy gene in most organisms; however S. cerevisiae contains a second homologue, DXO1, which also possesses decapping and 5'-3' exoribonuclease activity, whereas RAI1 has decapping and pyrophosphohydrolase activities []. This domain is also found in DXO1 homologue from Arabidopsis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Wang VY
Year: 2015
Journal: Nucleic Acids Res
Title: Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.
Volume: 43
Issue: 13
Pages: 6596-606
Publication
First Author: Girirajan S
Year: 2008
Journal: Eur J Hum Genet
Title: How much is too much? Phenotypic consequences of Rai1 overexpression in mice.
Volume: 16
Issue: 8
Pages: 941-54
Publication
First Author: Bi W
Year: 2007
Journal: Hum Mol Genet
Title: Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes.
Volume: 16
Issue: 15
Pages: 1802-13
Publication
First Author: Chang HC
Year: 2023
Journal: J Biol Chem
Title: rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice.
Volume: 299
Issue: 1
Pages: 102728
Publication
First Author: Seranski P
Year: 2001
Journal: Gene
Title: RAI1 is a novel polyglutamine encoding gene that is deleted in Smith-Magenis syndrome patients.
Volume: 270
Issue: 1-2
Pages: 69-76
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
Publication
First Author: Chang JH
Year: 2012
Journal: Nat Struct Mol Biol
Title: Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.
Volume: 19
Issue: 10
Pages: 1011-7
Publication
First Author: Kwasnik A
Year: 2019
Journal: Nucleic Acids Res
Title: Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity.
Volume: 47
Issue: 9
Pages: 4751-4764
Publication
First Author: Bi W
Year: 2005
Journal: Hum Mol Genet
Title: Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome.
Volume: 14
Issue: 8
Pages: 983-95
Publication    
First Author: Javed S
Year: 2023
Journal: Elife
Title: Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.
Volume: 12
Publication
First Author: Walz K
Year: 2006
Journal: J Clin Invest
Title: Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2).
Volume: 116
Issue: 11
Pages: 3035-41
Publication
First Author: Cao L
Year: 2014
Journal: Hum Mol Genet
Title: Correct developmental expression level of Rai1 in forebrain neurons is required for control of body weight, activity levels and learning and memory.
Volume: 23
Issue: 7
Pages: 1771-82
Publication
First Author: Javed S
Year: 2021
Journal: Hum Mol Genet
Title: Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.
Volume: 31
Issue: 2
Pages: 275-288
Publication
First Author: Huang WH
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome.
Volume: 115
Issue: 42
Pages: 10744-10749
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191185
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rai1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191185
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rai1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191185
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rai1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191185
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rai1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191185
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rai1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191185
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rai1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6181852
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191185
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rai1
Detected: true
Specimen Num: 7
Publication
First Author: Burns B
Year: 2010
Journal: Hum Mol Genet
Title: Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome.
Volume: 19
Issue: 20
Pages: 4026-42
Publication
First Author: Williams SR
Year: 2012
Journal: Am J Hum Genet
Title: Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity.
Volume: 90
Issue: 6
Pages: 941-9
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
Publication    
First Author: Diessler S
Year: 2017
Journal: Elife
Title: Rai1 frees mice from the repression of active wake behaviors by light.
Volume: 6
Publication
First Author: Huang WH
Year: 2016
Journal: Neuron
Title: Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.
Volume: 92
Issue: 2
Pages: 392-406
Publication
First Author: Toulouse A
Year: 2003
Journal: Genomics
Title: Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia.
Volume: 82
Issue: 2
Pages: 162-71
Publication
First Author: Lacaria M
Year: 2012
Journal: PLoS Genet
Title: A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men.
Volume: 8
Issue: 5
Pages: e1002713
Publication
First Author: Alaimo JT
Year: 2014
Journal: PLoS One
Title: Dietary regimens modify early onset of obesity in mice haploinsufficient for Rai1.
Volume: 9
Issue: 8
Pages: e105077
Publication
First Author: Girirajan S
Year: 2009
Journal: Mamm Genome
Title: Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgenic mice.
Volume: 20
Issue: 4
Pages: 247-55
Publication
First Author: Lacaria M
Year: 2013
Journal: Am J Med Genet A
Title: Circadian abnormalities in mouse models of Smith-Magenis syndrome: evidence for involvement of RAI1.
Volume: 161A
Issue: 7
Pages: 1561-8
Protein
Organism: Mus musculus/domesticus
Length: 1840  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
Publication
First Author: Yan J
Year: 2007
Journal: Am J Hum Genet
Title: Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.
Volume: 80
Issue: 3
Pages: 518-25
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Imai Y
Year: 1995
Journal: Brain Res Mol Brain Res
Title: Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain.
Volume: 31
Issue: 1-2
Pages: 1-9
GXD Expression      
Probe: MGI:3687562
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687571
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3687562
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687571
Age: postnatal
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3687562
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687571
Age: postnatal
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3687563
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687572
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3687563
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687572
Age: postnatal
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3687563
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687572
Age: postnatal
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3687564
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687573
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3687564
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687573
Age: postnatal
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3687564
Assay Type: RT-PCR
Annotation Date: 2006-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3687573
Age: postnatal
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 8
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 9
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal
Specimen Label: 10
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6306288
Age: embryonic day 13.0
Specimen Label: 11
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:6306288
Age: embryonic day 17.0
Specimen Label: 12
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6306288
Age: postnatal day 1
Specimen Label: 13
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal day 7
Specimen Label: 14
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:25615
Assay Type: Northern blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6306288
Age: postnatal week 7
Specimen Label: 15
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:6306286
Assay Type: Western blot
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6306293
Age: postnatal adult
Specimen Label: A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4886406
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945106
Age: embryonic day 11.5
Image: g00561 E11.5
Specimen Label: g00561 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4886406
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945106
Age: embryonic day 15.5
Image: g00561 E15.5
Specimen Label: g00561 E15.5
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-11
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1876728
Pattern: Single cells
Stage: TS28
Assay Id: MGI:5523464
Age: postnatal adult
Note: Expressed in very few subsets of cells.
Specimen Label: 2I
Detected: true
Specimen Num: 17
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5523464
Age: postnatal day 1
Specimen Label: 2G
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4886406
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945106
Age: embryonic day 15.5
Image: g00561 E15.5
Specimen Label: g00561 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4886406
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945106
Age: postnatal day 7
Image: g00561 P7
Specimen Label: g00561 P7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:25615
Assay Type: RNA in situ
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6306291
Age: postnatal adult
Specimen Label: 6A
Detected: true
Specimen Num: 1