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Search results 501 to 531 out of 531 for Atrx

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0.019s

Type

Details

Score

Publication

17609377 | -

First Author:	Argentaro A
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Volume:	104
Issue:	29
Pages:	11939-44

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Publication

23452848 | J:194039

First Author:	Baker SA
Year:	2013
Journal:	Cell
Title:	An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.
Volume:	152
Issue:	5
Pages:	984-96

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Publication

28368372 | J:246103

First Author:	Chatzinikolaou G
Year:	2017
Journal:	Nat Cell Biol
Title:	ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.
Volume:	19
Issue:	5
Pages:	421-432

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Publication

29107533 | J:249297

First Author:	Pathania M
Year:	2017
Journal:	Cancer Cell
Title:	H3.3^K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Volume:	32
Issue:	5
Pages:	684-700.e9

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Publication

24463520 | J:205556

First Author:	Christophorou MA
Year:	2014
Journal:	Nature
Title:	Citrullination regulates pluripotency and histone H1 binding to chromatin.
Volume:	507
Issue:	7490
Pages:	104-8

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Publication

10857753 | J:62173

First Author:	Aapola U
Year:	2000
Journal:	Genomics
Title:	Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Volume:	65
Issue:	3
Pages:	293-8

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Protein Domain

IPR025766 | ADD

Type:

Domain

Description:

One of the largest protein families in the human genome is the zinc fingerfamily that contains members involved in the regulation of transcriptionprocesses. The zinc finger domains have been classified based on the order ofcysteine (C) and histidine (H) residues. Zinc fingers are thought to mediateprotein-DNA and protein-protein interactions. The ADD (ATRX, DNMT3, DNMT3L)domain is a cysteine-rich region that consists of a C2C2-type zinc finger anda closely located domain of an imperfect PHD-type zinc finger with C4C4. The region between the two subdomains has a constant length, andit contains identical and conserved amino acids [, ]. The ADD domain binds to the histone H3 tail that is unmethylated at lysine 4 [, ].The ADD domain is present in chromatin-associated proteins that play a role inestablishing and/or maintaining a normal pattern of DNA methylation:DNMT3A, DNMT3B, DNA methyltransferases.DNMT3L, a DNMT3-like enzymatically inactive regulatory factor.ATRX, a large nuclear protein predominantly localized to heterochromatinand nuclear PML bodies. At the C terminus is a helicase/ATPase domain, which characterises ATRX as a member of the SNF2 (SWI/SNF) family of chromatin-associated proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].

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Publication

12058073 | J:122948

First Author:	Rouleau N
Year:	2002
Journal:	Mol Biol Cell
Title:	Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.
Volume:	13
Issue:	6
Pages:	2106-19

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Publication

26304540 | J:233377

First Author:	Udugama M
Year:	2015
Journal:	Nucleic Acids Res
Title:	Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.
Volume:	43
Issue:	21
Pages:	10227-37

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Publication

32395866 | J:313429

First Author:	Liu Z
Year:	2020
Journal:	EMBO J
Title:	SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.
Volume:	39
Issue:	13
Pages:	e103697

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Publication

16322236 | J:104088

First Author:	Datta J
Year:	2005
Journal:	Cancer Res
Title:	Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Volume:	65
Issue:	23
Pages:	10891-900

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Publication

10433969 | J:56959

First Author:	Xie S
Year:	1999
Journal:	Gene
Title:	Cloning, expression and chromosome locations of the human DNMT3 gene family.
Volume:	236
Issue:	1
Pages:	87-95

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Publication

17687327 | J:123743

First Author:	Ooi SK
Year:	2007
Journal:	Nature
Title:	DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Volume:	448
Issue:	7154
Pages:	714-7

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Publication

19834512 | -

First Author:	Otani J
Year:	2009
Journal:	EMBO Rep
Title:	Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
Volume:	10
Issue:	11
Pages:	1235-41

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Protein

P0DOY1

Organism:	Mus musculus/domesticus
Length:	740
Fragment?:	false

•

Protein

Q9CWR8

Organism:	Mus musculus/domesticus
Length:	421
Fragment?:	false

•

Protein

A3EWM2

Organism:	Mus musculus/domesticus
Length:	421
Fragment?:	false

•

Protein

O88508

Organism:	Mus musculus/domesticus
Length:	908
Fragment?:	false

•

Protein

O88509

Organism:	Mus musculus/domesticus
Length:	859
Fragment?:	false

•

Protein

Q3KR45

Organism:	Mus musculus/domesticus
Length:	860
Fragment?:	false

•

Protein

Q541E5

Organism:	Mus musculus/domesticus
Length:	796
Fragment?:	false

•

Publication

19131326 | -

First Author:	Sweet SM
Year:	2009
Journal:	Mol Cell Proteomics
Title:	Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume:	8
Issue:	5
Pages:	904-12

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Publication

24129315 | J:306378

First Author:	Guo A
Year:	2014
Journal:	Mol Cell Proteomics
Title:	Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Volume:	13
Issue:	1
Pages:	372-87

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Publication

19144319 | J:143718

First Author:	Trost M
Year:	2009
Journal:	Immunity
Title:	The phagosomal proteome in interferon-gamma-activated macrophages.
Volume:	30
Issue:	1
Pages:	143-54

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Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

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Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

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Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

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Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

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Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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