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Search results 201 to 207 out of 207 for Mrgprd

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0.016s

Type

Details

Score

Protein Domain

IPR026232 | MRGPCRD

Type:

Family

Description:

Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor D (MRGPRD), it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. It has been demonstrated that beta-alanine can act as an agonist at MRGPRD [].

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Protein

Q91ZB8

Organism:	Mus musculus/domesticus
Length:	321
Fragment?:	false

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Protein

Q5UCB4

Organism:	Mus musculus/domesticus
Length:	321
Fragment?:	false

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Publication

20004959 | J:157470

First Author:	Liu Q
Year:	2009
Journal:	Cell
Title:	Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Volume:	139
Issue:	7
Pages:	1353-65

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Publication

12084918 | J:77352

First Author:	Bender E
Year:	2002
Journal:	Proc Natl Acad Sci U S A
Title:	Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Volume:	99
Issue:	13
Pages:	8573-8

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Publication

18250432 | -

First Author:	Lee MG
Year:	2008
Journal:	J Immunol
Title:	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.
Volume:	180
Issue:	4
Pages:	2251-5

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Publication

21460831 | J:172290

First Author:	Wilson SR
Year:	2011
Journal:	Nat Neurosci
Title:	TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Volume:	14
Issue:	5
Pages:	595-602

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