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Search results 1 to 100 out of 161 for Fezf2

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Category: Publication
Type Details Score
Publication
First Author: Wang ZB
Year: 2011
Journal: Cereb Cortex
Title: Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells.
Volume: 21
Issue: 9
Pages: 2177-86
Publication  
First Author: Eckler MJ
Year: 2014
Journal: Neural Dev
Title: Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.
Volume: 9
Pages: 6
Publication
First Author: Takaba H
Year: 2015
Journal: Cell
Title: Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Volume: 163
Issue: 4
Pages: 975-87
Publication
First Author: McKenna WL
Year: 2011
Journal: J Neurosci
Title: Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.
Volume: 31
Issue: 2
Pages: 549-64
Publication
First Author: Tsyporin J
Year: 2021
Journal: Cell Rep
Title: Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.
Volume: 35
Issue: 12
Pages: 109269
Publication
First Author: Lodato S
Year: 2014
Journal: Nat Neurosci
Title: Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.
Volume: 17
Issue: 8
Pages: 1046-54
Publication
First Author: Tantirigama ML
Year: 2016
Journal: J Comp Neurol
Title: Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.
Volume: 524
Issue: 4
Pages: 829-45
Publication
First Author: Han W
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract.
Volume: 108
Issue: 7
Pages: 3041-6
Publication
First Author: Shimizu T
Year: 2010
Journal: Development
Title: Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.
Volume: 137
Issue: 11
Pages: 1875-85
Publication
First Author: Guo C
Year: 2013
Journal: Neuron
Title: Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes.
Volume: 80
Issue: 5
Pages: 1167-74
Publication
First Author: Eckler MJ
Year: 2011
Journal: J Comp Neurol
Title: Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.
Volume: 519
Issue: 10
Pages: 1829-46
Publication
First Author: Muralidharan B
Year: 2017
Journal: J Neurosci
Title: LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.
Volume: 37
Issue: 1
Pages: 194-203
Publication
First Author: McKenna WL
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex.
Volume: 112
Issue: 37
Pages: 11702-7
Publication
First Author: Zuccotti A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: The transcription factor Fezf2 directs the differentiation of neural stem cells in the subventricular zone toward a cortical phenotype.
Volume: 111
Issue: 29
Pages: 10726-31
Publication
First Author: Hirata-Fukae C
Year: 2014
Journal: Dev Dyn
Title: The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.
Volume: 243
Issue: 8
Pages: 1030-6
Publication
First Author: Tantirigama ML
Year: 2014
Journal: J Neurosci
Title: Expression of the developmental transcription factor Fezf2 identifies a distinct subpopulation of layer 5 intratelencephalic-projection neurons in mature mouse motor cortex.
Volume: 34
Issue: 12
Pages: 4303-8
Publication
First Author: Sadegh C
Year: 2021
Journal: PLoS One
Title: Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.
Volume: 16
Issue: 9
Pages: e0254113
Publication  
First Author: Suzuki-Kerr H
Year: 2018
Journal: Exp Eye Res
Title: Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina.
Volume: 171
Pages: 142-154
Publication
First Author: Shim S
Year: 2012
Journal: Nature
Title: Cis-regulatory control of corticospinal system development and evolution.
Volume: 486
Issue: 7401
Pages: 74-9
Publication
First Author: Deng H
Year: 2021
Journal: Cell
Title: A genetically defined insula-brainstem circuit selectively controls motivational vigor.
Volume: 184
Issue: 26
Pages: 6344-6360.e18
Publication
First Author: Hou Y
Year: 2021
Journal: Cell Rep
Title: Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain.
Volume: 34
Issue: 6
Pages: 108712
Publication
First Author: Zhang X
Year: 2021
Journal: Nat Neurosci
Title: Genetically identified amygdala-striatal circuits for valence-specific behaviors.
Volume: 24
Issue: 11
Pages: 1586-1600
Publication
First Author: Tomofuji Y
Year: 2020
Journal: Nat Immunol
Title: Chd4 choreographs self-antigen expression for central immune tolerance.
Volume: 21
Issue: 8
Pages: 892-901
Publication
First Author: Hirata T
Year: 2006
Journal: Development
Title: Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.
Volume: 133
Issue: 20
Pages: 3993-4004
Publication
First Author: Srinivasan K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Volume: 109
Issue: 47
Pages: 19071-8
Publication
First Author: Kwan KY
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.
Volume: 105
Issue: 41
Pages: 16021-6
Publication
First Author: Liu J
Year: 2022
Journal: Sci Adv
Title: FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons.
Volume: 8
Issue: 21
Pages: eabh3568
Publication
First Author: Galazo MJ
Year: 2023
Journal: Cell Rep
Title: Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.
Volume: 42
Issue: 8
Pages: 112957
Publication
First Author: Diao Y
Year: 2018
Journal: Cereb Cortex
Title: Reciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus.
Volume: 28
Issue: 4
Pages: 1168-1182
Publication
First Author: Ehrman JM
Year: 2022
Journal: J Neurosci
Title: Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants.
Volume: 42
Issue: 16
Pages: 3344-3364
Publication
First Author: Hashimoto H
Year: 2000
Journal: Mech Dev
Title: Expression of the zinc finger gene fez-like in zebrafish forebrain.
Volume: 97
Issue: 1-2
Pages: 191-5
Publication
First Author: Matsuo-Takasaki M
Year: 2000
Journal: Mech Dev
Title: Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos.
Volume: 93
Issue: 1-2
Pages: 201-4
Publication
First Author: Wuttke TV
Year: 2018
Journal: Nat Neurosci
Title: Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation.
Volume: 21
Issue: 4
Pages: 517-529
Publication
First Author: Yang Z
Year: 2001
Journal: Dev Biol
Title: A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression.
Volume: 231
Issue: 1
Pages: 138-48
Publication
First Author: Rouaux C
Year: 2013
Journal: Nat Cell Biol
Title: Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo.
Volume: 15
Issue: 2
Pages: 214-21
Publication
First Author: BRAIN Initiative Cell Census Network (BICCN).
Year: 2021
Journal: Nature
Title: A multimodal cell census and atlas of the mammalian primary motor cortex.
Volume: 598
Issue: 7879
Pages: 86-102
Publication
First Author: Huilgol D
Year: 2023
Journal: Neuron
Title: Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex.
Volume: 111
Issue: 16
Pages: 2557-2569.e4
Publication
First Author: Matho KS
Year: 2021
Journal: Nature
Title: Genetic dissection of the glutamatergic neuron system in cerebral cortex.
Volume: 598
Issue: 7879
Pages: 182-187
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Peng H
Year: 2021
Journal: Nature
Title: Morphological diversity of single neurons in molecularly defined cell types.
Volume: 598
Issue: 7879
Pages: 174-181
Publication
First Author: Chen JG
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex.
Volume: 102
Issue: 49
Pages: 17792-7
Publication
First Author: Sahni V
Year: 2021
Journal: Cell Rep
Title: Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting.
Volume: 37
Issue: 3
Pages: 109843
Publication
First Author: Janssens DH
Year: 2017
Journal: Dev Cell
Title: An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division.
Volume: 40
Issue: 4
Pages: 367-380.e7
Publication
First Author: Weng M
Year: 2010
Journal: Dev Cell
Title: dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.
Volume: 18
Issue: 1
Pages: 126-35
Publication
First Author: Qu C
Year: 2013
Journal: Gene Expr Patterns
Title: Gene expression and IG-DMR hypomethylation of maternally expressed gene 3 in developing corticospinal neurons.
Volume: 13
Issue: 1-2
Pages: 51-6
Publication
First Author: Itoh Y
Year: 2023
Journal: Cell Rep
Title: Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations.
Volume: 42
Issue: 3
Pages: 112182
Publication
First Author: Fujita Y
Year: 2020
Journal: Cell Rep
Title: Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain.
Volume: 31
Issue: 4
Pages: 107580
Publication  
First Author: Azim E
Year: 2009
Journal: Cereb Cortex
Title: Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development.
Volume: 19 Suppl 1
Pages: i62-9
Publication
First Author: Hirata T
Year: 2004
Journal: Dev Dyn
Title: Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.
Volume: 230
Issue: 3
Pages: 546-56
Publication
First Author: Qu C
Year: 2016
Journal: J Biol Chem
Title: Transient Expression of Fez Family Zinc Finger 2 Protein Regulates the Brn3b Gene in Developing Retinal Ganglion Cells.
Volume: 291
Issue: 14
Pages: 7661-8
Publication
First Author: Gu Z
Year: 2017
Journal: Science
Title: Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
Volume: 357
Issue: 6349
Pages: 400-404
Publication
First Author: Sagan SA
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
Volume: 120
Issue: 30
Pages: e2306572120
Publication  
First Author: MacDonald JL
Year: 2018
Journal: eNeuro
Title: Caveolin1 Identifies a Specific Subpopulation of Cerebral Cortex Callosal Projection Neurons (CPN) Including Dual Projecting Cortical Callosal/Frontal Projection Neurons (CPN/FPN).
Volume: 5
Issue: 1
Publication
First Author: Maynard KR
Year: 2012
Journal: J Neurosci
Title: DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.
Volume: 32
Issue: 47
Pages: 16637-50
Publication
First Author: Song JHT
Year: 2023
Journal: J Neurosci
Title: Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord.
Volume: 43
Issue: 11
Pages: 1871-1887
Publication  
First Author: Bayam E
Year: 2015
Journal: BMC Genomics
Title: Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.
Volume: 16
Pages: 681
Publication
First Author: Armentano M
Year: 2007
Journal: Nat Neurosci
Title: COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.
Volume: 10
Issue: 10
Pages: 1277-86
Publication
First Author: Leone DP
Year: 2015
Journal: Cereb Cortex
Title: Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.
Volume: 25
Issue: 10
Pages: 3406-19
Publication
First Author: Flore G
Year: 2017
Journal: Cereb Cortex
Title: Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis.
Volume: 27
Issue: 2
Pages: 1629-1643
Publication
First Author: Arlotta P
Year: 2005
Journal: Neuron
Title: Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
Volume: 45
Issue: 2
Pages: 207-21
Publication
First Author: Cain JT
Year: 2014
Journal: Dev Neurobiol
Title: Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain.
Volume: 74
Issue: 1
Pages: 63-81
Publication
First Author: Sansom SN
Year: 2005
Journal: Development
Title: Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap.
Volume: 132
Issue: 17
Pages: 3947-61
Publication
First Author: Ben-Reuven L
Year: 2021
Journal: Mol Psychiatry
Title: Dynamics of cortical progenitors and production of subcerebral neurons are altered in embryos of a maternal inflammation model for autism.
Volume: 26
Issue: 5
Pages: 1535-1550
Publication
First Author: Nielsen JV
Year: 2014
Journal: Cereb Cortex
Title: Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex.
Volume: 24
Issue: 5
Pages: 1216-29
Publication
First Author: Fame RM
Year: 2017
Journal: Cereb Cortex
Title: Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Volume: 27
Issue: 3
Pages: 1817-1830
Publication
First Author: Molyneaux BJ
Year: 2005
Journal: Neuron
Title: Fezl is required for the birth and specification of corticospinal motor neurons.
Volume: 47
Issue: 6
Pages: 817-31
Publication
First Author: Britanova O
Year: 2008
Journal: Neuron
Title: Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.
Volume: 57
Issue: 3
Pages: 378-92
Publication
First Author: Caubit X
Year: 2016
Journal: Nat Genet
Title: TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
Volume: 48
Issue: 11
Pages: 1359-1369
Publication
First Author: Kaur N
Year: 2020
Journal: Neuron
Title: Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.
Volume: 107
Issue: 6
Pages: 1197-1211.e9
Publication
First Author: Roberts JM
Year: 2014
Journal: J Comp Neurol
Title: Splicing factor TRA2B is required for neural progenitor survival.
Volume: 522
Issue: 2
Pages: 372-92
Publication
First Author: Sun J
Year: 2015
Journal: Nucleic Acids Res
Title: Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.
Volume: 43
Issue: 14
Pages: 6827-46
Publication
First Author: Gan Q
Year: 2014
Journal: Stem Cells
Title: Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells.
Volume: 32
Issue: 1
Pages: 45-58
Publication
First Author: Faedo A
Year: 2008
Journal: Cereb Cortex
Title: COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
Volume: 18
Issue: 9
Pages: 2117-31
Publication
First Author: Woodworth MB
Year: 2016
Journal: Cell Rep
Title: Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.
Volume: 15
Issue: 5
Pages: 999-1012
Publication
First Author: Shetty AS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Lhx2 regulates a cortex-specific mechanism for barrel formation.
Volume: 110
Issue: 50
Pages: E4913-21
Publication  
First Author: He L
Year: 2021
Journal: Development
Title: PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.
Volume: 148
Issue: 6
Publication
First Author: Zhou CJ
Year: 2006
Journal: Neuroscience
Title: Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.
Volume: 142
Issue: 4
Pages: 1119-31
Publication  
First Author: Han S
Year: 2018
Journal: Development
Title: A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.
Volume: 145
Issue: 19
Publication
First Author: Markenscoff-Papadimitriou E
Year: 2021
Journal: Cell Rep
Title: Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.
Volume: 37
Issue: 10
Pages: 110089
Publication
First Author: Stottmann RW
Year: 2013
Journal: Hum Mol Genet
Title: A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse.
Volume: 22
Issue: 20
Pages: 4053-63
Publication
First Author: Betancourt J
Year: 2014
Journal: J Comp Neurol
Title: Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons.
Volume: 522
Issue: 1
Pages: 6-35
Publication
First Author: Lodato S
Year: 2011
Journal: Neuron
Title: Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex.
Volume: 69
Issue: 4
Pages: 763-79
Publication
First Author: Mattar P
Year: 2008
Journal: Mol Cell Biol
Title: Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity.
Volume: 28
Issue: 5
Pages: 1456-69
Publication
First Author: Cho A
Year: 2014
Journal: Neuron
Title: Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.
Volume: 82
Issue: 1
Pages: 109-124
Publication
First Author: Lai T
Year: 2008
Journal: Neuron
Title: SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.
Volume: 57
Issue: 2
Pages: 232-47
Publication
First Author: Flore G
Year: 2017
Journal: Cereb Cortex
Title: Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome.
Volume: 27
Issue: 3
Pages: 2210-2225
Publication
First Author: Dennis DJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex.
Volume: 114
Issue: 25
Pages: E4934-E4943
Publication
First Author: Galazo MJ
Year: 2016
Journal: Neuron
Title: Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.
Volume: 91
Issue: 1
Pages: 90-106
Publication
First Author: Caronia G
Year: 2010
Journal: J Neurosci
Title: Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior.
Volume: 30
Issue: 18
Pages: 6291-301
Publication
First Author: Cappello S
Year: 2012
Journal: Neuron
Title: A radial glia-specific role of RhoA in double cortex formation.
Volume: 73
Issue: 5
Pages: 911-24
Publication
First Author: Inoue T
Year: 2008
Journal: J Neurosci
Title: Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.
Volume: 28
Issue: 18
Pages: 4712-25
Publication
First Author: Baranek C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.
Volume: 109
Issue: 9
Pages: 3546-51
Publication
First Author: Bedogni F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Volume: 107
Issue: 29
Pages: 13129-34
Publication
First Author: Tonchev AB
Year: 2016
Journal: Mol Brain
Title: Zbtb20 modulates the sequential generation of neuronal layers in developing cortex.
Volume: 9
Issue: 1
Pages: 65
Publication
First Author: Sakurai Y
Year: 2010
Journal: Dev Biol
Title: Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.
Volume: 347
Issue: 2
Pages: 392-403
Publication
First Author: Ideguchi M
Year: 2010
Journal: J Neurosci
Title: Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.
Volume: 30
Issue: 3
Pages: 894-904
Publication
First Author: Lavado A
Year: 2008
Journal: Development
Title: Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
Volume: 135
Issue: 3
Pages: 441-50
Publication  
First Author: Ypsilanti AR
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional network orchestrating regional patterning of cortical progenitors.
Volume: 118
Issue: 51
Publication
First Author: Tan SL
Year: 2012
Journal: Development
Title: Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.
Volume: 139
Issue: 20
Pages: 3806-16
Publication
First Author: Tuoc TC
Year: 2009
Journal: J Neurosci
Title: Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.
Volume: 29
Issue: 26
Pages: 8335-49