Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:7532890 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3577227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7536960 |
Age: |
postnatal day 2 |
Image: |
8E |
Note: |
Expressed in a small cluster of cells. |
Specimen Label: |
8E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6719594 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3812820 |
|
Stage: |
TS20 |
Assay Id: |
MGI:6726291 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
2H |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huber K |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. |
Volume: |
380 |
Issue: |
2 |
Pages: |
286-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lymperopoulos A |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction. |
Volume: |
285 |
Issue: |
21 |
Pages: |
16378-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Souza Cordeiro LM |
Year: |
2021 |
Journal: |
Diabetologia |
Title: |
Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice. |
Volume: |
64 |
Issue: |
1 |
Pages: |
181-194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wen PJ |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane. |
Volume: |
7 |
|
Pages: |
12604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kennedy B |
Year: |
2002 |
Journal: |
Ann N Y Acad Sci |
Title: |
Reduction of adrenal and kidney epinephrine and phenylethanolamine N-methyltransferase in AP-2 knockout mouse fetuses. |
Volume: |
971 |
|
Pages: |
92-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson MA |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. |
Volume: |
61 |
Issue: |
3 |
Pages: |
285-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zammit DJ |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. |
Volume: |
22 |
Issue: |
3 |
Pages: |
946-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allmendinger A |
Year: |
2003 |
Journal: |
Mech Dev |
Title: |
Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret. |
Volume: |
120 |
Issue: |
3 |
Pages: |
299-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan WH |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3929 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonthuis PJ |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions. |
Volume: |
38 |
Issue: |
10 |
Pages: |
110500 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan WH |
Year: |
2016 |
Journal: |
Dev Neurobiol |
Title: |
Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells. |
Volume: |
76 |
Issue: |
2 |
Pages: |
137-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
VanDusen NJ |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. |
Volume: |
388 |
Issue: |
2 |
Pages: |
149-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang CC |
Year: |
2012 |
Journal: |
Mol Cell Endocrinol |
Title: |
Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice. |
Volume: |
361 |
Issue: |
1-2 |
Pages: |
165-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gut P |
Year: |
2005 |
Journal: |
Development |
Title: |
Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells. |
Volume: |
132 |
Issue: |
20 |
Pages: |
4611-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gahring LC |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Nicotinic receptor Alpha7 expression during mouse adrenal gland development. |
Volume: |
9 |
Issue: |
8 |
Pages: |
e103861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reiprich S |
Year: |
2008 |
Journal: |
Mol Biol Cell |
Title: |
SoxE proteins are differentially required in mouse adrenal gland development. |
Volume: |
19 |
Issue: |
4 |
Pages: |
1575-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van de Putte T |
Year: |
2007 |
Journal: |
Hum Mol Genet |
Title: |
Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome. |
Volume: |
16 |
Issue: |
12 |
Pages: |
1423-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oberle S |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla. |
Volume: |
26 |
Issue: |
6 |
Pages: |
1823-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang CC |
Year: |
2012 |
Journal: |
Endocrinology |
Title: |
Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. |
Volume: |
153 |
Issue: |
10 |
Pages: |
4749-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang CC |
Year: |
2010 |
Journal: |
Endocrinology |
Title: |
Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog. |
Volume: |
151 |
Issue: |
3 |
Pages: |
1119-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cole TJ |
Year: |
1995 |
Journal: |
Genes Dev |
Title: |
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. |
Volume: |
9 |
Issue: |
13 |
Pages: |
1608-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guillemot F |
Year: |
1993 |
Journal: |
Cell |
Title: |
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. |
Volume: |
75 |
Issue: |
3 |
Pages: |
463-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wildner H |
Year: |
2008 |
Journal: |
Development |
Title: |
Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. |
Volume: |
135 |
Issue: |
3 |
Pages: |
473-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanemaaijer ES |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype. |
Volume: |
118 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magli A |
Year: |
2014 |
Journal: |
Stem Cells |
Title: |
Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells. |
Volume: |
32 |
Issue: |
8 |
Pages: |
2072-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Novoselova TV |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. |
|
|
Pages: |
fj201701274RR |
|
•
•
•
•
•
|
Publication |
First Author: |
Martersteck EM |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Diverse Central Projection Patterns of Retinal Ganglion Cells. |
Volume: |
18 |
Issue: |
8 |
Pages: |
2058-2072 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harris JA |
Year: |
2014 |
Journal: |
Front Neural Circuits |
Title: |
Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. |
Volume: |
8 |
|
Pages: |
76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Q |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Regional and cell-type-specific afferent and efferent projections of the mouse claustrum. |
Volume: |
42 |
Issue: |
2 |
Pages: |
112118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuoco JA |
Year: |
2018 |
Journal: |
Cerebellum |
Title: |
Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background. |
Volume: |
17 |
Issue: |
2 |
Pages: |
173-190 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sundberg JP |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. |
Volume: |
12 |
Issue: |
7 |
Pages: |
e0180682 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 59, Ralph L Brinster |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447990 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7536965 |
Age: |
postnatal newborn |
Image: |
2E/F |
Note: |
Similar to Pnmt and XGAL staining, but there were a few cells that stained positively for Th that were not stained with XGAL (noradrenergic minority). |
Specimen Label: |
2E/F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baetge EE |
Year: |
1988 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina. |
Volume: |
85 |
Issue: |
10 |
Pages: |
3648-52 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion EX45, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Fung KM |
Year: |
1994 |
Journal: |
Lab Invest |
Title: |
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. |
Volume: |
70 |
Issue: |
1 |
Pages: |
114-24 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Conserved_site |
Description: |
Several cytoplasmic vertebrate methyltransferases are evolutionary related [], includingnicotinamide N-methyltransferase () (NNMT); phenylethanolamine N-methyltransferase () (PNMT); and thioether S-methyltransferase () (TEMT). NNMT catalyses the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. PNMT catalyses the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin; and TEMT catalyses themethylation of dimethyl sulphide into trimethylsulphonium. These three enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32kDa.This entry represents the most conserved region, a stretch of 16 residues which are located in the N-terminal section of these enzymes. |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson CS |
Year: |
2018 |
Journal: |
J Comp Neurol |
Title: |
Neurotransmitter diversity in pre-synaptic terminals located in the parvicellular neuroendocrine paraventricular nucleus of the rat and mouse hypothalamus. |
Volume: |
526 |
Issue: |
8 |
Pages: |
1287-1306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida-Hiroi M |
Year: |
2002 |
Journal: |
Mol Psychiatry |
Title: |
Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice. |
Volume: |
7 |
Issue: |
9 |
Pages: |
967-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi E |
Year: |
2006 |
Journal: |
Comp Med |
Title: |
Enhanced expression of Ca2+ channel alpha1A and beta4 subunits and phosphorylated tyrosine hydroxylase in the adrenal gland of N-type Ca2+ channel alpha1B subunit-deficient mice with a CBA/JN genetic background. |
Volume: |
56 |
Issue: |
3 |
Pages: |
168-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeong KH |
Year: |
2000 |
Journal: |
Endocrinology |
Title: |
Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. |
Volume: |
141 |
Issue: |
3 |
Pages: |
1142-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoehe MR |
Year: |
1992 |
Journal: |
Hum Mol Genet |
Title: |
Genetic linkage of the human gene for phenylethanolamine N-methyltransferase (PNMT), the adrenaline-synthesizing enzyme, to DNA markers on chromosome 17q21-q22. |
Volume: |
1 |
Issue: |
3 |
Pages: |
175-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haemisch A |
Year: |
1994 |
Journal: |
Physiol Behav |
Title: |
Effects of environmental enrichment on aggressive behavior, dominance hierarchies, and endocrine states in male DBA/2J mice. |
Volume: |
56 |
Issue: |
5 |
Pages: |
1041-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haemisch A |
Year: |
1996 |
Journal: |
Physiol Behav |
Title: |
Dissociation between adrenal tyrosinehydroxylase and phenylethanolamine N-methyltransferase activities following repeated experience of defeats in individually housed male DBA/2J mice. |
Volume: |
59 |
Issue: |
6 |
Pages: |
1117-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaneda N |
Year: |
1998 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Identification of the essential cysteinyl residue located in the active site of human phenylethanolamine N-methyltransferase. |
Volume: |
249 |
Issue: |
2 |
Pages: |
405-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bornstein SR |
Year: |
1999 |
Journal: |
FASEB J |
Title: |
Adrenomedullary function is severely impaired in 21-hydroxylase-deficient mice. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1185-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hill GD |
Year: |
2003 |
Journal: |
Endocr Pathol |
Title: |
A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice. |
Volume: |
14 |
Issue: |
1 |
Pages: |
81-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aksoy S |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. |
Volume: |
269 |
Issue: |
20 |
Pages: |
14835-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stroth N |
Year: |
2010 |
Journal: |
Neuroscience |
Title: |
Stress hormone synthesis in mouse hypothalamus and adrenal gland triggered by restraint is dependent on pituitary adenylate cyclase-activating polypeptide signaling. |
Volume: |
165 |
Issue: |
4 |
Pages: |
1025-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haemisch A |
Year: |
1994 |
Journal: |
J Exp Anim Sci |
Title: |
The cage design affects intermale aggression in small groups of male laboratory mice: strain specific consequences on social organization, and endocrine activations in two inbred strains (DBA/2J and CBA/J). |
Volume: |
36 |
Issue: |
4-5 |
Pages: |
101-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang P |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis. |
Volume: |
12 |
|
Pages: |
616583 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Methyl transfer from the ubiquitous S-adenosyl-L-methionine (AdoMet) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms ranging from bacteria to plants and mammals. The reaction is catalysed by methyltransferases (Mtases) and modifies DNA, RNA, proteins and small molecules, such as catechol for regulatory purposes. The various aspects of the role of DNA methylation in prokaryotic restriction-modification systems and in a number of cellular processes in eukaryotes including gene regulation and differentiation is well documented.Three classes of DNA Mtases transfer the methyl group from AdoMet to the target base to form either N-6-methyladenine, or N-4-methylcytosine, or C-5- methylcytosine. In C-5-cytosine Mtases, ten conserved motifs are arranged in the same order []. Motif I (a glycine-rich or closely related consensus sequence; FAGxGG in M.HhaI []), shared by other AdoMet-Mtases [], is part of the cofactor binding site and motif IV (PCQ) is part of the catalytic site. In contrast, sequence comparison among N-6-adenine and N-4-cytosine Mtases indicated two of the conserved segments [], although more conserved segments may be present. One of them corresponds to motif I in C-5-cytosine Mtases, and the other is named (D/N/S)PP(Y/F). Crystal structures are known for a number of Mtases [, , , ]. The cofactor binding sites are almost identical and the essential catalytic amino acids coincide. The comparable protein folding and the existence of equivalent amino acids in similar secondary and tertiary positions indicate that many (if not all) AdoMet-Mtases have a common catalytic domain structure. This permits tertiary structure prediction of other DNA, RNA, protein, and small-molecule AdoMet-Mtases from their amino acid sequences [].Several cytoplasmic vertebrate methyltransferases are evolutionary related [], includingnicotinamide N-methyltransferase () (NNMT); phenylethanolamine N-methyltransferase () (PNMT); and thioether S-methyltransferase () (TEMT). NNMT catalyses the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. PNMT catalyses the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin; and TEMT catalyses themethylation of dimethyl sulphide into trimethylsulphonium. These three enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32kDa. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng X |
Year: |
1993 |
Journal: |
Cell |
Title: |
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. |
Volume: |
74 |
Issue: |
2 |
Pages: |
299-307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klimasauskas S |
Year: |
1989 |
Journal: |
Nucleic Acids Res |
Title: |
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases. |
Volume: |
17 |
Issue: |
23 |
Pages: |
9823-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ingrosso D |
Year: |
1989 |
Journal: |
J Biol Chem |
Title: |
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases. |
Volume: |
264 |
Issue: |
33 |
Pages: |
20131-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schluckebier G |
Year: |
1995 |
Journal: |
Gene |
Title: |
A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase. |
Volume: |
157 |
Issue: |
1-2 |
Pages: |
131-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar S |
Year: |
1994 |
Journal: |
Nucleic Acids Res |
Title: |
The DNA (cytosine-5) methyltransferases. |
Volume: |
22 |
Issue: |
1 |
Pages: |
1-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labahn J |
Year: |
1994 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine. |
Volume: |
91 |
Issue: |
23 |
Pages: |
10957-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schluckebier G |
Year: |
1995 |
Journal: |
J Mol Biol |
Title: |
Universal catalytic domain structure of AdoMet-dependent methyltransferases. |
Volume: |
247 |
Issue: |
1 |
Pages: |
16-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|