Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (theIFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ]. |
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•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2002 |
Journal: |
Biochem J |
Title: |
The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR). |
Volume: |
366 |
Issue: |
Pt 1 |
Pages: |
175-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh M |
Year: |
2012 |
Journal: |
J Cell Biochem |
Title: |
Increased interaction between PACT molecules in response to stress signals is required for PKR activation. |
Volume: |
113 |
Issue: |
8 |
Pages: |
2754-64 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the first DSRM of PRKRA. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the second DSRM of PRKRA. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the third DSRM of PRKRA. |
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•
•
•
•
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Strain |
Attribute String: |
mutant strain, chemically induced mutation, coisogenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
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•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 |
Background: |
C57BL/6J-Dicer1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 |
Background: |
involves: 129S7/SvEvBrd * FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1<+> |
Background: |
involves: 129S7/SvEvBrd * FVB/N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 |
Background: |
involves: 129S7/SvEvBrd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE69882 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE69881 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Davalos V |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
Rolling the dice to discover the role of DICER in tumorigenesis. |
Volume: |
21 |
Issue: |
6 |
Pages: |
717-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(KRT14-cre)52Smr/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Zp3-cre)93Knw/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
313
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee Y |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
The role of PACT in the RNA silencing pathway. |
Volume: |
25 |
Issue: |
3 |
Pages: |
522-32 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Myh6-cre)2182Mds/? |
Background: |
involves: 129S7/SvEvBrd * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/? |
Background: |
involves: 129S7/SvEvBrd * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
Background: |
involves: 129S2/SvPas * 129S7/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/? |
Background: |
involves: 129S7/SvEvBrd * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/? |
Background: |
involves: 129S7/SvEvBrd * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE22023 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(KRT5-rtTA)1Glk/? Tg(tetO-cre)1Jaw/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Pax8/Pax8<+> |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1<+> Emx1/Emx1<+> |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Stra8-icre)1Reb/? |
Background: |
involves: 129S1/SvImJ * 129S7/SvEvBrd * FVB/NJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2007 |
Journal: |
Nat Genet |
Title: |
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. |
Volume: |
39 |
Issue: |
3 |
Pages: |
380-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao H |
Year: |
2010 |
Journal: |
J Dent Res |
Title: |
MicroRNAs play a critical role in tooth development. |
Volume: |
89 |
Issue: |
8 |
Pages: |
779-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gelfand BD |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1686-93 |
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•
•
•
•
•
|
Publication |
First Author: |
Yi R |
Year: |
2008 |
Journal: |
Nature |
Title: |
A skin microRNA promotes differentiation by repressing 'stemness'. |
Volume: |
452 |
Issue: |
7184 |
Pages: |
225-9 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE68537 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dicer1/Dicer1 Tg(Ddx4-cre)1Dcas/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE46264 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Kerur N |
Year: |
2018 |
Journal: |
Nat Med |
Title: |
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. |
Volume: |
24 |
Issue: |
1 |
Pages: |
50-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin HP |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination. |
Volume: |
8 |
Issue: |
1 |
Pages: |
3817 |
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•
•
•
•
•
|
Publication |
First Author: |
Chuang CH |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells. |
Volume: |
40 |
Issue: |
11 |
Pages: |
4914-24 |
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•
•
•
•
•
|
Publication |
First Author: |
Goettsch C |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
miR-125b regulates calcification of vascular smooth muscle cells. |
Volume: |
179 |
Issue: |
4 |
Pages: |
1594-600 |
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•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2019 |
Journal: |
Biol Reprod |
Title: |
CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†. |
Volume: |
101 |
Issue: |
1 |
Pages: |
50-62 |
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•
•
•
•
•
|
Publication |
First Author: |
Landry-Truchon K |
Year: |
2020 |
Journal: |
Dis Model Mech |
Title: |
Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis. |
Volume: |
13 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tiwari P |
Year: |
2014 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents. |
Volume: |
278 |
Issue: |
2 |
Pages: |
148-58 |
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•
•
•
•
•
|
Publication |
First Author: |
Akpa MM |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells. |
Volume: |
291 |
Issue: |
8 |
Pages: |
3785-95 |
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•
•
•
•
•
|
Publication |
First Author: |
Han X |
Year: |
2017 |
Journal: |
Biol Reprod |
Title: |
MicroRNA-21 plays a pivotal role in the oocyte-secreted factor-induced suppression of cumulus cell apoptosis. |
Volume: |
96 |
Issue: |
6 |
Pages: |
1167-1180 |
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•
•
•
•
•
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Publication |
First Author: |
Ruiz-Roso MB |
Year: |
2020 |
Journal: |
Front Genet |
Title: |
Intestinal Lipid Metabolism Genes Regulated by miRNAs. |
Volume: |
11 |
|
Pages: |
707 |
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•
•
•
•
•
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Publication |
First Author: |
Kerur N |
Year: |
2013 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. |
Volume: |
54 |
Issue: |
12 |
Pages: |
7395-401 |
|
•
•
•
•
•
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Publication |
First Author: |
Anderegg A |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e1003973 |
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•
•
•
•
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Publication |
First Author: |
Ota H |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions. |
Volume: |
14 |
Issue: |
2 |
Pages: |
e0211739 |
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•
•
•
•
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Publication |
First Author: |
Tapocik JD |
Year: |
2016 |
Journal: |
Front Mol Neurosci |
Title: |
MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1. |
Volume: |
9 |
|
Pages: |
20 |
|
•
•
•
•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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