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Search results 1 to 4 out of 4 for Trrap

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
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Type Details Score
Protein Domain
IPR046805 | Tra1_ring
Type: Repeat
Description: This entry includes transcription-associated protein 1 (Tra1) from yeast and TRRAP from mammals. Budding yeast Tra1 is a subunit of SAGA and NuA4 histone acetyltransferase complexes [, ]. Human TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT) [].This entry represents part of the Tra1 protein composed of α-solenoid repeats that form a ring region [].
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Protein Domain
IPR033317 | TRA1/TRRAP
Type: Family
Description: This entry includes transcription-associated protein 1 (Tra1) from yeast and TRRAP from mammals. Budding yeast Tra1 is a subunit of SAGA and NuA4 histone acetyltransferase complexes [, ]. Human TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT) [].
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Protein Domain
IPR046807 | Tra1_central
Type: Repeat
Description: This entry includes transcription-associated protein 1 (Tra1) from yeast and TRRAP from mammals. Budding yeast Tra1 is a subunit of SAGA and NuA4 histone acetyltransferase complexes [, ]. Human TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT) [].This entry represents part of the Tra1 protein composed of α-solenoid repeats that forms the central region []. This is named as central due to its position relative to the ring region.
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Protein Domain
IPR037826 | TAF5L
Type: Family
Description: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65kDa subunit 5L (TAF5L) is a component of the a component of the PCAF complex, the human version of the yeast SAGA complex []. TAF5L is also a component of the STAGA transcription coactivator-HAT complex [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].The STAGA transcription coactivator-HAT complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors. The STAGA complex is composed of at least SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 [].
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