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Search results 101 to 178 out of 178 for Spred1

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5000689
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5541249
Age: embryonic day 15.5
Image: GUDMAP:6911
Specimen Label: GUDMAP:6911
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4437631
Assay Type: RNA in situ
Annotation Date: 2010-03-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4437633
Age: embryonic day 17.0
Specimen Label: 1A E17
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4437631
Assay Type: RNA in situ
Annotation Date: 2010-03-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4437633
Age: embryonic day 17.0
Specimen Label: S1a
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:5000689
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541249
Age: embryonic day 15.5
Image: GUDMAP:6911
Specimen Label: GUDMAP:6911
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000689
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541249
Age: embryonic day 15.5
Image: GUDMAP:6912
Specimen Label: GUDMAP:6912
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5000689
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5541249
Age: embryonic day 15.5
Image: GUDMAP:6911
Specimen Label: GUDMAP:6911
Detected: false
Specimen Num: 1
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Publication
11493923 | J:70801
First Author: Wakioka T
Year: 2001
Journal: Nature
Title: Spred is a Sprouty-related suppressor of Ras signalling.
Volume: 412
Issue: 6847
Pages: 647-51
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Publication
16115197 | J:106893
First Author: Nonami A
Year: 2005
Journal: Genes Cells
Title: The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.
Volume: 10
Issue: 9
Pages: 887-95
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Publication
15580519 | J:108170
First Author: Engelhardt CM
Year: 2004
Journal: Histochem Cell Biol
Title: Expression and subcellular localization of Spred proteins in mouse and human tissues.
Volume: 122
Issue: 6
Pages: 527-38
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Publication
18694565 | J:139708
First Author: Wang S
Year: 2008
Journal: Dev Cell
Title: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis.
Volume: 15
Issue: 2
Pages: 261-71
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Publication
12646235 | J:82566
First Author: Kato R
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
Volume: 302
Issue: 4
Pages: 767-72
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Publication
26075267 | J:312570
 
First Author: Assinder SJ
Year: 2015
Journal: Biomed Res Int
Title: Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer: a working hypothesis.
Volume: 2015
Pages: 827462
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Publication
17974561 | J:130605
First Author: Chandramouli S
Year: 2008
Journal: J Biol Chem
Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Volume: 283
Issue: 3
Pages: 1679-91
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Publication
29501879 | J:287039
 
First Author: Zhao G
Year: 2018
Journal: Exp Eye Res
Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.
Volume: 170
Pages: 148-159
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Publication
17438136 | J:122355
First Author: Taniguchi K
Year: 2007
Journal: Mol Cell Biol
Title: Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.
Volume: 27
Issue: 12
Pages: 4541-50
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Publication
26362256 | J:226487
First Author: Bagheri-Fam S
Year: 2015
Journal: Hum Mol Genet
Title: FGFR2 mutation in 46,XY sex reversal with craniosynostosis.
Volume: 24
Issue: 23
Pages: 6699-710
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Publication
32452519 | J:293772
First Author: Bird AD
Year: 2020
Journal: Hum Mol Genet
Title: Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes.
Volume: 29
Issue: 13
Pages: 2148-2161
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Publication
18270576 | J:154087
First Author: Trimarchi JM
Year: 2008
Journal: PLoS One
Title: Individual retinal progenitor cells display extensive heterogeneity of gene expression.
Volume: 3
Issue: 2
Pages: e1588
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Publication
28489004 | J:259186
   
First Author: Heng X
Year: 2017
Journal: Elife
Title: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
Volume: 6
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Publication
28705898 | J:243411
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Spred1<em2Smoc> | MGI:7292576
Name: sprouty protein with EVH-1 domain 1, related sequence; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
15710406 | -
First Author: Harmer NJ
Year: 2005
Journal: FEBS Lett
Title: 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
Volume: 579
Issue: 5
Pages: 1161-6
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Allele
Spred1<em1Smoc> | MGI:7292575
Name: sprouty protein with EVH-1 domain 1, related sequence; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0070484 | Legius syndrome
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Strain
MGI:6476373 | C57BL/6J-Spred1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
26635368 | -
First Author: Hirata Y
Year: 2016
Journal: J Biol Chem
Title: Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1.
Volume: 291
Issue: 7
Pages: 3124-34
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Publication
15213456 | -
First Author: Zimmermann J
Year: 2004
Journal: J Biomol NMR
Title: 1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.
Volume: 29
Issue: 3
Pages: 435-6
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Protein Domain
IPR041937 | SPRE_EVH1
Type: Domain
Description: The SPRE (also known as SPRED) proteins have the following domains: an N-terminal EVH1 domain, a unique KBD (c-Kit kinase binding) domain which is phosphorylated by the stem cell factor receptor c-Kit, and a C-terminal cysteine-rich SPR (Sprouty-related) domain which is involved in membrane localization. This entry represents the EVH1 domain of SPRE. Proteins containing this domaininclude Spred1 which interacts with both Ras and Raf through its SPR domain; Spred2 which is the most abundant isoform; and Spred3 which has a non-functional KBD and maintains the inhibitory action on Raf. Legius syndrome is caused by heterozygous mutations in Spred1. Both EVH1 and SPR domains are involved in the inhibition of the MAP kinase pathway by SPRE proteins. The specific function of the EVH1 domain is unknown and there are no known interacting proteins to date. EVH1 has a PH-like fold, despite having minimal sequence similarity to PH or PTB domains [, , ].
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Publication
34895467 | J:320780
   
First Author: Kim S
Year: 2021
Journal: Elife
Title: Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua.
Volume: 10
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Publication
33589748 | J:308178
First Author: Nguyen LXT
Year: 2021
Journal: Leukemia
Title: Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia.
Volume: 35
Issue: 8
Pages: 2285-2298
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Publication
35412895 | J:329928
First Author: Hoang DH
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: MicroRNA networks in FLT3-ITD acute myeloid leukemia.
Volume: 119
Issue: 16
Pages: e2112482119
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Publication
33188851 | J:302114
First Author: Gui Y
Year: 2020
Journal: Exp Cell Res
Title: Soluble epoxide hydrolase inhibitors improve angiogenic function of endothelial progenitor cells via ERK/p38-mediated miR-126 upregulation in myocardial infarction mice after exercise.
Volume: 397
Issue: 2
Pages: 112360
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Publication
27780851 | J:260782
First Author: Hartmann D
Year: 2016
Journal: Circulation
Title: MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
Volume: 134
Issue: 24
Pages: 1973-1990
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Protein
Q924S7
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q6P6N5
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q924S8
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
Q5SRF9
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
A0A0R4J0K0
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q5SRF8
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Publication
9883880 | J:51858
First Author: Callebaut I
Year: 1998
Journal: FEBS Lett
Title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.
Volume: 441
Issue: 2
Pages: 181-5
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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