Phospholipid-transporting ATPase VB (also known as ATP10B) belongs to the IV subfamily of the P-type ATPases (P4-ATPase) family. P4-ATPases are phospholipid flippases that translocate phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of cellular membranes. ATP10C requires CDC50A for its exit from the endoplasmic reticulum (ER) and final subcellular localisation []. ATP10B is the catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes [].
