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Search results 1 to 100 out of 271 for Gch1

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:951753
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825732
Age: embryonic day 14.5
Image: Additional file 4 Gch1
Specimen Label: Additional file 4 Gch1
Detected: true
Specimen Num: 1
Publication
First Author: McNeill E
Year: 2018
Journal: Nat Commun
Title: Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
Volume: 9
Issue: 1
Pages: 5409
Publication
First Author: Douglas G
Year: 2015
Journal: Dev Biol
Title: A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Volume: 399
Issue: 1
Pages: 129-38
Publication
First Author: Douglas G
Year: 2018
Journal: Cardiovasc Res
Title: Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Volume: 114
Issue: 10
Pages: 1385-1399
Publication  
First Author: McNeill E
Year: 2015
Journal: Free Radic Biol Med
Title: Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
Volume: 79
Pages: 206-16
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190381
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Gch1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190381
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Gch1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190381
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Gch1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190381
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Gch1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190381
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Gch1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190381
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Gch1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6173422
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190381
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Gch1
Detected: true
Specimen Num: 7
Publication
First Author: Adlam D
Year: 2012
Journal: Cardiovasc Res
Title: Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Volume: 93
Issue: 4
Pages: 694-701
Publication
First Author: Zschiebsch K
Year: 2019
Journal: J Cell Mol Med
Title: Mast cell tetrahydrobiopterin contributes to itch in mice.
Volume: 23
Issue: 2
Pages: 985-1000
Publication
First Author: Shimoji M
Year: 1999
Journal: J Neurochem
Title: GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice.
Volume: 72
Issue: 2
Pages: 757-64
Publication
First Author: Canevari L
Year: 1999
Journal: J Neurochem
Title: Stimulation of the brain NO/cyclic GMP pathway by peripheral administration of tetrahydrobiopterin in the hph-1 mouse.
Volume: 73
Issue: 6
Pages: 2563-8
Publication
First Author: Nandi M
Year: 2005
Journal: Circulation
Title: Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse.
Volume: 111
Issue: 16
Pages: 2086-90
Publication
First Author: Montañez CS
Year: 1999
Journal: Mol Genet Metab
Title: Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene.
Volume: 68
Issue: 1
Pages: 91-2
Publication
First Author: Gütlich M
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity.
Volume: 203
Issue: 3
Pages: 1675-81
Publication
First Author: Tatham AL
Year: 2009
Journal: J Biol Chem
Title: GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
Volume: 284
Issue: 20
Pages: 13660-8
Publication
First Author: Khoo JP
Year: 2004
Journal: Mol Genet Metab
Title: Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Volume: 82
Issue: 3
Pages: 251-4
GO Term
Publication
First Author: Cronin SJF
Year: 2018
Journal: Nature
Title: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Volume: 563
Issue: 7732
Pages: 564-568
Publication
First Author: d'Uscio LV
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Volume: 301
Issue: 6
Pages: H2227-34
Publication
First Author: Xie HH
Year: 2010
Journal: Hypertension
Title: GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
Volume: 56
Issue: 6
Pages: 1137-44
Publication
First Author: Chuaiphichai S
Year: 2014
Journal: Hypertension
Title: Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Volume: 64
Issue: 3
Pages: 530-40
Publication
First Author: Chuaiphichai S
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.
Volume: 324
Issue: 4
Pages: H430-H442
Publication  
First Author: Wu HE
Year: 2016
Journal: Sci Rep
Title: Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy.
Volume: 6
Pages: 27925
Publication
First Author: Carnicer R
Year: 2012
Journal: Circ Res
Title: Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Volume: 111
Issue: 6
Pages: 718-27
Publication
First Author: Peterson TE
Year: 2009
Journal: Hypertension
Title: Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells.
Volume: 53
Issue: 2
Pages: 189-95
Publication
First Author: Latremoliere A
Year: 2015
Journal: Neuron
Title: Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Volume: 86
Issue: 6
Pages: 1393-406
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Nomura T
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I.
Volume: 191
Issue: 2
Pages: 523-7
Publication  
First Author: Jiang X
Year: 2019
Journal: Metabolism
Title: A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.
Volume: 94
Pages: 96-104
Publication  
First Author: Ichinose H
Year: 2013
Journal: Adv Pharmacol
Title: GTP cyclohydrolase regulation: implications for brain development and function.
Volume: 68
Pages: 23-35
Publication
First Author: Pelletier I
Year: 2001
Journal: Mech Dev
Title: Cloning and developmental expression of zebrafish GTP cyclohydrolase I.
Volume: 109
Issue: 1
Pages: 99-103
Publication
First Author: Ichinose H
Year: 1994
Journal: Nat Genet
Title: Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene.
Volume: 8
Issue: 3
Pages: 236-42
Publication
First Author: Ichinose H
Year: 1995
Journal: J Biol Chem
Title: Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.
Volume: 270
Issue: 17
Pages: 10062-71
Publication
First Author: Tie L
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
Volume: 296
Issue: 6
Pages: E1423-9
Publication
First Author: Belik J
Year: 2011
Journal: Free Radic Biol Med
Title: Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse.
Volume: 51
Issue: 12
Pages: 2227-33
Publication
First Author: Tie L
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.
Volume: 306
Issue: 10
Pages: E1120-31
Publication  
First Author: Santhanam AV
Year: 2015
Journal: Brain Res
Title: Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.
Volume: 1625
Pages: 198-205
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Stage: TS20
Assay Id: MGI:3760519
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Stage: TS20
Assay Id: MGI:3760519
Age: embryonic day 12.5
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:3760519
Age: postnatal day 0
Specimen Label: WT
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:3760519
Age: postnatal day 0
Specimen Label: KO
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697418
Stage: TS18
Assay Id: MGI:3760522
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Stage: TS20
Assay Id: MGI:3760522
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:3760522
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1614014
Stage: TS14
Assay Id: MGI:3760522
Age: embryonic day 9.0
Specimen Label: E9
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3760516
Assay Type: RT-PCR
Annotation Date: 2007-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614016
Stage: TS16
Assay Id: MGI:3760522
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6305356
Age: postnatal adult
Image: 1
Specimen Label: GCH +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6305356
Age: postnatal adult
Image: 1
Specimen Label: GCH +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6305357
Age: embryonic day 9.5
Image: 2
Specimen Label: +/+ 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6305357
Age: embryonic day 10.5
Image: 2
Specimen Label: +/+ 10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6305357
Age: embryonic day 11.5
Image: 2
Specimen Label: +/+ 11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6305357
Age: embryonic day 12.5
Image: 2
Specimen Label: +/+ 12/5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6305357
Age: embryonic day 9.5
Image: 2
Specimen Label: +/- 9.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6305357
Age: embryonic day 10.5
Image: 2
Specimen Label: +/- 10.5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6305357
Age: embryonic day 11.5
Image: 2
Specimen Label: +/- 11.5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6305357
Age: embryonic day 12.5
Image: 2
Specimen Label: +/- 12.5
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6305357
Age: embryonic day 9.5
Image: 2
Specimen Label: -/- 9.5
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6305357
Age: embryonic day 10.5
Image: 2
Specimen Label: -/- 10.5
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6305357
Age: embryonic day 11.5
Image: 2
Specimen Label: -/- 11.5
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:6305349
Assay Type: RT-PCR
Annotation Date: 2019-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6305357
Age: embryonic day 12.5
Image: 2
Specimen Label: -/- 12.5
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Specimen Label: EB402; Specimen B382
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1716122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309772
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423101
Age: embryonic day 14.5
Image: EB402; Specimen B382
Specimen Label: EB402; Specimen B382
Detected: true
Specimen Num: 1