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Search results 301 to 398 out of 398 for Mal

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Type Details Score
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 70
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: DBA2J F P70
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 10
Note: Expression levels are lower than those seen at later ages.
Specimen Label: DBA2J M P10
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 21
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: DBA2J M P21
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 70
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: DBA2J M P70
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 10
Note: Expression levels are lower than those seen at later ages.
Specimen Label: FVBN F P10
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 21
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: FVBN F P21
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 70
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: FVBN F P70
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 10
Note: Expression levels are lower than those seen at later ages.
Specimen Label: FVBN M P10
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 21
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: FVBN M P21
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 70
Note: No significant differences in expression were observed across the four genetic backgrounds and two sexes tested.
Specimen Label: FVBN M P70
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:5774754
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5774765
Age: postnatal day 10
Note: Expression levels are lower than those seen at later ages.
Specimen Label: BalbC F P10
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692288
Age: postnatal adult
Image: BCM_2398785
Note: vas deferens
Specimen Label: BCM_2398785
Specimen Num: 2
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692288
Age: postnatal adult
Image: BCM_2398784
Specimen Label: BCM_2398784
Specimen Num: 1
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692288
Age: postnatal adult
Image: BCM_2398785
Specimen Label: BCM_2398785
Specimen Num: 2
Publication    
First Author: Mastrangeli R
Year: 1999
Journal: GenBank Submission
Title: Mus musculus ARS component B gene, exons 1-3
Pages: AJ132356
Publication
First Author: Arredondo J
Year: 2005
Journal: J Invest Dermatol
Title: Biological effects of SLURP-1 on human keratinocytes.
Volume: 125
Issue: 6
Pages: 1236-41
Protein Domain
Type: Family
Description: Secreted Ly-6/uPAR-related protein 1 (SLURP-1) belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins. SLURP1 has antitumor activity. It was found to be a marker of late differentiation of the skin. SLURP1 is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin [, , ]. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterised by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens) [, ].
Publication
First Author: Levy CW
Year: 2002
Journal: Structure
Title: Insights into enzyme evolution revealed by the structure of methylaspartate ammonia lyase.
Volume: 10
Issue: 1
Pages: 105-13
Publication
First Author: Mouilleron S
Year: 2011
Journal: Sci Signal
Title: Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Volume: 4
Issue: 177
Pages: ra40
Publication
First Author: Hirano H
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL.
Volume: 414
Issue: 2
Pages: 373-8
Publication
First Author: Pawłowski R
Year: 2010
Journal: EMBO J
Title: An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
Volume: 29
Issue: 20
Pages: 3448-58
Publication
First Author: Mercher T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
Volume: 98
Issue: 10
Pages: 5776-9
Publication
First Author: Baarlink C
Year: 2013
Journal: Science
Title: Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
Volume: 340
Issue: 6134
Pages: 864-7
Publication
First Author: Fletcher CF
Year: 1996
Journal: Cell
Title: Absence epilepsy in tottering mutant mice is associated with calcium channel defects.
Volume: 87
Issue: 4
Pages: 607-17
Publication
First Author: Suzuki T
Year: 2004
Journal: Nat Genet
Title: Mutations in EFHC1 cause juvenile myoclonic epilepsy.
Volume: 36
Issue: 8
Pages: 842-9
Publication
First Author: Miralles F
Year: 2003
Journal: Cell
Title: Actin dynamics control SRF activity by regulation of its coactivator MAL.
Volume: 113
Issue: 3
Pages: 329-42
Publication
First Author: Vartiainen MK
Year: 2007
Journal: Science
Title: Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.
Volume: 316
Issue: 5832
Pages: 1749-52
Publication
First Author: Mouilleron S
Year: 2008
Journal: EMBO J
Title: Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
Volume: 27
Issue: 23
Pages: 3198-208
Publication
First Author: Descot A
Year: 2009
Journal: Mol Cell
Title: Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction.
Volume: 35
Issue: 3
Pages: 291-304
Publication
First Author: Wickramasinghe SR
Year: 2008
Journal: Neuron
Title: Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.
Volume: 58
Issue: 4
Pages: 532-45
Publication
First Author: Zhou S
Year: 2008
Journal: J Neuroimmunol
Title: Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Volume: 194
Issue: 1-2
Pages: 70-82
Publication
First Author: Corr SC
Year: 2014
Journal: Mucosal Immunol
Title: MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
Volume: 7
Issue: 1
Pages: 57-67
Publication
First Author: Yamamoto A
Year: 1998
Journal: J Neurosci
Title: Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy.
Volume: 18
Issue: 6
Pages: 2063-74
Publication
First Author: Smith-Hicks C
Year: 2010
Journal: Nat Neurosci
Title: SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Volume: 13
Issue: 9
Pages: 1082-9
Publication
First Author: Letts VA
Year: 1997
Journal: Genomics
Title: Genetic and physical maps of the stargazer locus on mouse chromosome 15.
Volume: 43
Issue: 1
Pages: 62-8
Publication
First Author: Li W
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.
Volume: 477
Issue: 3
Pages: 509-14
Protein
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
Publication
First Author: Du KL
Year: 2003
Journal: Mol Cell Biol
Title: Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.
Volume: 23
Issue: 7
Pages: 2425-37
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
Publication
First Author: Asuncion M
Year: 2002
Journal: J Biol Chem
Title: The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step.
Volume: 277
Issue: 10
Pages: 8306-11
Publication
First Author: Long X
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Myocardin: new therapeutic agent in vascular disease?
Volume: 33
Issue: 10
Pages: 2284-5
Publication
First Author: Morita T
Year: 2014
Journal: J Cell Biol
Title: Arp5 is a key regulator of myocardin in smooth muscle cells.
Volume: 204
Issue: 5
Pages: 683-96
Publication
First Author: Selvaraj A
Year: 2003
Journal: J Biol Chem
Title: Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.
Volume: 278
Issue: 43
Pages: 41977-87
Protein Domain
Type: Family
Description: Myocardin (Myocd) is a coactivator of serum response factor (SRF), which is a key regulator of the expression of smooth and cardiac muscle genes. Myocardin plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) [, ]. It contains the RPEL repeats, which are monomeric globular actin (G-actin) binding elements. However, it binds to actin-related protein 5 (Arp5) instead of conventional actin, resulting in a significant suppression of Myocd activity [].Myocardin-related transcription factor A (MRTFA, also known MKL1) is an actin-binding transcriptional coactivator whose localisation is regulated by its interaction with monomeric actin (G-actin) []. Its N-terminal domain consists of three tandem RPEL repeats, where the G-actin binding site and the nuclear localisation signal can be found [, ]. In the nucleus MAL associates with SRF (serum response factor) and activates transcription of SRF:MAL-dependent target genes []. It has been implicated in human diseases, such as acute megakaryocytic leukemia []and other cancers [].MKL2 binds to and activates SRF (serum response factor) similar to myocardin and MKL1 [].This entry includes Myocardin and MKL/myocardin-like protein 1/2 (MKL1/2).
Publication  
First Author: He X
Year: 2021
Journal: Front Immunol
Title: Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier.
Volume: 12
Pages: 745854
Publication
First Author: Ohnishi H
Year: 2012
Journal: PLoS One
Title: TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.
Volume: 7
Issue: 6
Pages: e38423
Publication
First Author: Swamynathan S
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea.
Volume: 53
Issue: 13
Pages: 8433-46
Publication
First Author: Noebels JL
Year: 1984
Journal: Nature
Title: A single gene error of noradrenergic axon growth synchronizes central neurones.
Volume: 310
Issue: 5976
Pages: 409-11
Publication
First Author: Yaghootfam A
Year: 2005
Journal: Eur J Neurosci
Title: Delay of myelin formation in arylsulphatase A-deficient mice.
Volume: 21
Issue: 3
Pages: 711-20
Publication
First Author: Siednienko J
Year: 2010
Journal: Eur J Immunol
Title: TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Volume: 40
Issue: 11
Pages: 3150-60
Publication
First Author: Talbot S
Year: 2009
Journal: Immunology
Title: Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
Volume: 128
Issue: 4
Pages: 472-83
Publication
First Author: Miggin SM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Volume: 104
Issue: 9
Pages: 3372-7
Publication
First Author: Blum M
Year: 1995
Journal: Neurobiol Aging
Title: GDNF mRNA expression in normal postnatal development, aging, and in Weaver mutant mice.
Volume: 16
Issue: 6
Pages: 925-9
Publication
First Author: Aviello G
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Volume: 306
Issue: 9
Pages: G769-78
Publication
First Author: Bitto A
Year: 2018
Journal: Biochim Biophys Acta
Title: Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes.
Volume: 1864
Issue: 2
Pages: 632-639
Publication
First Author: Caty V
Year: 2006
Journal: Br J Dermatol
Title: Multiple large surface photodynamic therapy sessions with topical methylaminolaevulinate in PTCH heterozygous mice.
Volume: 154
Issue: 4
Pages: 740-2
Publication
First Author: Buser AM
Year: 2009
Journal: Mol Cell Neurosci
Title: The septin cytoskeleton in myelinating glia.
Volume: 40
Issue: 2
Pages: 156-66
Publication
First Author: Zuscik MJ
Year: 2000
Journal: Nat Med
Title: Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy.
Volume: 6
Issue: 12
Pages: 1388-94
Publication
First Author: Yamazaki K
Year: 1992
Journal: Lab Anim Sci
Title: Convulsions in senescence-accelerated mice (SAM-R/1/Eis).
Volume: 42
Issue: 4
Pages: 378-81
Publication
First Author: Busche S
Year: 2008
Journal: J Cell Sci
Title: Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling.
Volume: 121
Issue: Pt 7
Pages: 1025-35
Publication
First Author: Sacre SM
Year: 2007
Journal: J Immunol
Title: Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
Volume: 178
Issue: 4
Pages: 2148-54
Publication
First Author: Kenny EF
Year: 2009
Journal: J Immunol
Title: MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Volume: 183
Issue: 6
Pages: 3642-51
Publication
First Author: Lysakova-Devine T
Year: 2010
Journal: J Immunol
Title: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Volume: 185
Issue: 7
Pages: 4261-71
Publication  
First Author: Bent MAM
Year: 2022
Journal: Behav Brain Res
Title: Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice.
Volume: 419
Pages: 113703
Publication
First Author: Kooblall KG
Year: 2023
Journal: JBMR Plus
Title: A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (NFIX) Gene Has Phenotypic Features of Marshall-Smith Syndrome.
Volume: 7
Issue: 6
Pages: e10739
Publication
First Author: Ruwanpura SM
Year: 2013
Journal: PLoS One
Title: Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice.
Volume: 8
Issue: 10
Pages: e78095
Publication
First Author: Kennedy CL
Year: 2014
Journal: Oncogene
Title: Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis.
Volume: 33
Issue: 19
Pages: 2540-6
Publication
First Author: Sharfaei S
Year: 2002
Journal: Arch Dermatol Res
Title: Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice.
Volume: 294
Issue: 5
Pages: 237-42
Publication
First Author: Mehta RG
Year: 2014
Journal: PLoS One
Title: Differential roles of ERα and ERβ in normal and neoplastic development in the mouse mammary gland.
Volume: 9
Issue: 11
Pages: e113175
Publication
First Author: Swamynathan S
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health.
Volume: 56
Issue: 13
Pages: 7888-96
Publication
First Author: Seo S
Year: 2014
Journal: Epilepsia
Title: Altered thalamic GABAA-receptor subunit expression in the stargazer mouse model of absence epilepsy.
Volume: 55
Issue: 2
Pages: 224-32
Publication  
First Author: Delgado-Escueta AV
Year: 1999
Journal: Adv Neurol
Title: Mapping and positional cloning of common idiopathic generalized epilepsies: juvenile myoclonus epilepsy and childhood absence epilepsy.
Volume: 79
Pages: 351-74
Protein
Organism: Mus musculus/domesticus
Length: 1029  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 964  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 979  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1080  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1080  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1091  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 948  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1079  
Fragment?: true
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations