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Search results 201 to 300 out of 306 for Soat1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5309831
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1802422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423157
Age: embryonic day 14.5
Image: EB1236; Specimen B489
Specimen Label: EB1236; Specimen B489
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5309831
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423157
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EB1236; Specimen B489
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5309831
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423157
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EB1236; Specimen B489
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3202055
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828371
Age: embryonic day 14.5
Image: euxassay_004596_15
Specimen Label: euxassay_004596_15
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:3202055
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828371
Age: embryonic day 14.5
Image: euxassay_004596_16
Specimen Label: euxassay_004596_16
Detected: true
Specimen Num: 13
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Publication
8579615 | J:31174
First Author: Green S
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL.
Volume: 218
Issue: 3
Pages: 924-9
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Publication
18772481 | J:144089
First Author: Su Z
Year: 2009
Journal: J Lipid Res
Title: Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.
Volume: 50
Issue: 1
Pages: 116-25
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Publication
26982734 | J:232711
First Author: Yang W
Year: 2016
Journal: Nature
Title: Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Volume: 531
Issue: 7596
Pages: 651-5
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Publication
22811412 | J:188044
First Author: Xie C
Year: 2012
Journal: J Lipid Res
Title: Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.
Volume: 53
Issue: 10
Pages: 2092-101
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Publication
15845358 | J:97572
First Author: Rodriguez A
Year: 2005
Journal: Biochem Biophys Res Commun
Title: ACAT1 deletion in murine macrophages associated with cytotoxicity and decreased expression of collagen type 3A1.
Volume: 331
Issue: 1
Pages: 61-8
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Publication
25930235 | J:224493
First Author: Shibuya Y
Year: 2015
Journal: Neurobiol Aging
Title: Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Volume: 36
Issue: 7
Pages: 2248-2259
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Publication
1225763 | J:5644
First Author: Taylor BA
Year: 1975
Journal: Genet Res
Title: Mapping the adrenal lipid depletion gene of the AKR/J mouse strain.
Volume: 26
Issue: 3
Pages: 307-12
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Publication
29549095 | J:261514
First Author: Zhu Y
Year: 2018
Journal: J Lipid Res
Title: In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis.
Volume: 59
Issue: 5
Pages: 820-829
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Publication
29533741 | J:270248
First Author: Huang LH
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.
Volume: 315
Issue: 3
Pages: E340-E356
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Publication
36691048 | J:344544
First Author: Zaidi SAH
Year: 2023
Journal: J Neuroinflammation
Title: Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization.
Volume: 20
Issue: 1
Pages: 14
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Publication
35507892 | J:346341
First Author: Rogers MA
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
Volume: 119
Issue: 18
Pages: e2201646119
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Publication
6230784 | J:40007
First Author: Festenstein H
Year: 1984
Journal: Transplantation
Title: BALB.D2-Mlsa--a new congenic mouse strain.
Volume: 37
Issue: 3
Pages: 322-4
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Publication
24657401 | J:279220
First Author: Tomita K
Year: 2014
Journal: J Hepatol
Title: Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.
Volume: 61
Issue: 1
Pages: 98-106
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Publication
16387874 | J:106521
First Author: Su Z
Year: 2006
Journal: Genetics
Title: Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene.
Volume: 172
Issue: 3
Pages: 1799-807
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Publication
31495784 | J:283047
First Author: Melton EM
Year: 2019
Journal: J Biol Chem
Title: Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.
Volume: 294
Issue: 43
Pages: 15836-15849
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Publication
30282838 | J:278559
First Author: Yamazaki H
Year: 2019
Journal: J Atheroscler Thromb
Title: Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells.
Volume: 26
Issue: 3
Pages: 246-259
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Publication
11160132 | J:66975
First Author: Fazio S
Year: 2001
Journal: J Clin Invest
Title: Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Volume: 107
Issue: 2
Pages: 163-71
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Publication
27514747 | J:237041
First Author: Saadane A
Year: 2016
Journal: J Biol Chem
Title: Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells.
Volume: 291
Issue: 39
Pages: 20427-39
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Publication
22669916 | J:186555
First Author: Nguyen TM
Year: 2012
Journal: J Lipid Res
Title: ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.
Volume: 53
Issue: 8
Pages: 1598-609
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Publication
22474282 | J:185622
First Author: Rogers MA
Year: 2012
Journal: J Biol Chem
Title: Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.
Volume: 287
Issue: 21
Pages: 17483-92
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Publication
23846496 | J:278047
First Author: Huang LH
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.
Volume: 33
Issue: 9
Pages: 2081-7
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Publication
15851589 | J:111648
First Author: Su YR
Year: 2005
Journal: Circulation
Title: Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Volume: 111
Issue: 18
Pages: 2373-81
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Publication
281712 | J:6070
First Author: Wilson CM
Year: 1978
Journal: Proc Natl Acad Sci U S A
Title: Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
Volume: 75
Issue: 11
Pages: 5623-6
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Publication
2176177 | J:4436
First Author: Gessler M
Year: 1990
Journal: Hum Genet
Title: The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome.
Volume: 86
Issue: 2
Pages: 135-8
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Publication
- | J:12048
 
First Author: Festenstein H
Year: 1977
Journal: Immunogenetics
Title: Location of Mls locus on mouse chromosome 1.
Volume: 5
Pages: 357-361
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Publication
- | J:30359
       
First Author: Sundberg JP (ed.)
Year: 1994
Title: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools
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Publication
15845870 | J:101230
First Author: Wu MK
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice.
Volume: 289
Issue: 3
Pages: G456-61
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Publication
26801614 | J:231221
First Author: Huang LH
Year: 2016
Journal: J Biol Chem
Title: Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Volume: 291
Issue: 12
Pages: 6232-44
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Publication
25522268 | J:279738
 
First Author: Yin YW
Year: 2014
Journal: Cell Death Dis
Title: TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression.
Volume: 5
Pages: e1574
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Publication
31329164 | J:280927
First Author: Ducasa GM
Year: 2019
Journal: J Clin Invest
Title: ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.
Volume: 129
Issue: 8
Pages: 3387-3400
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Publication
10727439 | J:61147
First Author: Accad M
Year: 2000
Journal: J Clin Invest
Title: Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Volume: 105
Issue: 6
Pages: 711-9
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Publication
10777503 | J:63468
First Author: Yagyu H
Year: 2000
Journal: J Biol Chem
Title: Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
Volume: 275
Issue: 28
Pages: 21324-30
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Publication
20133765 | J:157545
First Author: Bryleva EY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Volume: 107
Issue: 7
Pages: 3081-6
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Publication
25339759 | J:217151
First Author: Shibuya Y
Year: 2014
Journal: J Neurosci
Title: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Volume: 34
Issue: 43
Pages: 14484-501
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Publication
540002 | J:6286
First Author: Wilcox FH
Year: 1979
Journal: Biochem Genet
Title: Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme.
Volume: 17
Issue: 11-12
Pages: 1093-107
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Publication
6934364 | J:6437
First Author: Elliott RW
Year: 1980
Journal: Mol Gen Genet
Title: Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney.
Volume: 180
Issue: 1
Pages: 17-22
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Publication
12114523 | J:78956
First Author: Johnstone CN
Year: 2002
Journal: J Biol Chem
Title: Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.
Volume: 277
Issue: 37
Pages: 34531-9
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Publication
10594239 | J:58692
First Author: Frank D
Year: 1999
Journal: Mamm Genome
Title: A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.
Volume: 10
Issue: 12
Pages: 1150-9
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Publication
7592824 | J:29712
First Author: Uelmen PJ
Year: 1995
Journal: J Biol Chem
Title: Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro.
Volume: 270
Issue: 44
Pages: 26192-201
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Publication
9651528 | J:49057
First Author: Yamazaki K
Year: 1998
Journal: Gene
Title: Cloning of 5'-flanking region and a polymorphic CTT trinucleotide repeat within 5'-untranslated region of mouse R-type calcium channel alpha1-subunit (Cchra1) gene, and its genetic mapping.
Volume: 214
Issue: 1-2
Pages: 199-204
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Publication
18464936 | J:136217
First Author: Matynia A
Year: 2008
Journal: PLoS One
Title: A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
Volume: 3
Issue: 5
Pages: e2121
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Publication
7165695 | J:7001
First Author: Szymura JM
Year: 1982
Journal: Biochem Genet
Title: Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse.
Volume: 20
Issue: 11-12
Pages: 1211-9
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Publication
2993224 | J:7978
First Author: Elliott RW
Year: 1985
Journal: In Vitro Cell Dev Biol
Title: Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse.
Volume: 21
Issue: 8
Pages: 477-84
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Publication
8672144 | J:34470
First Author: Burmeister M
Year: 1996
Journal: Mamm Genome
Title: Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes.
Volume: 7
Issue: 7
Pages: 558-9
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Publication
17916774 | J:127711
First Author: Wang SS
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.
Volume: 27
Issue: 12
Pages: 2671-6
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Publication
9250876 | J:38541
First Author: Welch CL
Year: 1997
Journal: Mamm Genome
Title: Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis.
Volume: 8
Issue: 8
Pages: 620-1
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Publication
- | J:20642
     
First Author: Taylor BA
Year: 1994
Journal: Personal Communication
Title: Corrections and additional typings to RI Strain Distribution patterns.
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
8827514 | J:34178
First Author: Welch CL
Year: 1996
Journal: J Lipid Res
Title: Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Volume: 37
Issue: 7
Pages: 1406-21
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
29938858 | J:269315
First Author: Jain P
Year: 2018
Journal: Stem Cells
Title: Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity.
Volume: 36
Issue: 10
Pages: 1603-1616
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Allele
Soat1<tm1Smoc> | MGI:7292513
Name: sterol O-acyltransferase 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6429586 | C57BL/6J-Soat1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
9756920 | -
First Author: Oelkers P
Year: 1998
Journal: J Biol Chem
Title: Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.
Volume: 273
Issue: 41
Pages: 26765-71
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Publication
11108732 | -
First Author: Lee RG
Year: 2000
Journal: J Lipid Res
Title: Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates.
Volume: 41
Issue: 12
Pages: 1991-2001
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Publication
16518538 | -
First Author: Chang C
Year: 2006
Journal: Acta Biochim Biophys Sin (Shanghai)
Title: Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.
Volume: 38
Issue: 3
Pages: 151-6
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Publication
25450374 | J:220279
First Author: Lopez AM
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.
Volume: 454
Issue: 1
Pages: 162-6
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Protein Domain
IPR030687 | Sterol_acyltranf_meta
Type: Family
Description: Sterol O-acyltransferase 1 (SOAT1; also known as ACAT1) and sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) both play a role in the formation of fatty acid-cholesterol esters []. Cholesterol esters are less soluble in membranes than cholesterol and accumulate in atherosclerotic lesions, making ACAT inhibitors a pharmacological target against atherosclerosis [, ]. SOAT1 is present in steroidogenic tissues, kidneys, sebaceous glands and macrophages. SOAT2 is expressed predominantly in the liver and small intestine [, ].
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Allele
Soat1<ald> | MGI:1856648
 
Name: sterol O-acyltransferase 1; adrenocortical lipid depletion
Allele Type: Spontaneous
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Strain
MGI:2164218 | AKR/J-Soat1<ald>
Attribute String: mutant strain, coisogenic, spontaneous mutation
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Genotype
Genotype
Symbol: Soat1/Soat1
Background: AKR
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Soat1/Soat1
Background: AKR/O
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:2164894 | AKR/O
Attribute String: inbred strain
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