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Search results 101 to 199 out of 199 for Prx

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0.03s
Type Details Score
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Mohammad Bohlooly-Y
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Protein
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
Publication
First Author: Carreras A
Year: 2019
Journal: BMC Biol
Title: In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.
Volume: 17
Issue: 1
Pages: 4
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: C57BL/6 * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Pseudogene
Type: pseudogene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Pseudogene
Type: pseudogene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Choi J
Year: 2003
Journal: J Biol Chem
Title: Crystal structure of Escherichia coli thiol peroxidase in the oxidized state: insights into intramolecular disulfide formation and substrate binding in atypical 2-Cys peroxiredoxins.
Volume: 278
Issue: 49
Pages: 49478-86
Protein Domain
Type: Family
Description: Escherichia coli protein Tpx []is a bacterial, periplasmic antioxidant protein with a thiol peroxidase activity. It is a small protein of 18kDa whose sequence is well conserved in other bacterial species. Tpx which differs from other peroxidases (PRXs) in that it shows substrate specificity toward alkyl hydroperoxides over hydrogen peroxide. As with all other PRXs, the peroxidatic cysteine (N-terminal) of Tpx is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Tpx is able to resolve this intermediate by forming an intramolecular disulfide bond with a conserved C-terminal cysteine (the resolving cysteine), which can then be reduced by thioredoxin []. This differs from the typical 2-cys PRX which resolves the oxidized cysteine by forming an intermolecular disulfide bond with the resolving cysteine from the other subunit of the homodimer. Atypical 2-cys PRX homodimers have a loop-based interface (A-type for alternate), in contrast with the B-type interface of typical 2-cys and 1-cys PRXs [].
Publication
First Author: Li S
Year: 2005
Journal: J Mol Biol
Title: Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin.
Volume: 346
Issue: 4
Pages: 1035-46
Publication
First Author: Deponte M
Year: 2005
Journal: Mol Biochem Parasitol
Title: Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx.
Volume: 140
Issue: 1
Pages: 87-96
Publication
First Author: Chen JW
Year: 2000
Journal: J Biol Chem
Title: 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
Volume: 275
Issue: 37
Pages: 28421-7
Publication  
First Author: Dietz KJ
Year: 2003
Journal: Annu Rev Plant Biol
Title: Plant peroxiredoxins.
Volume: 54
Pages: 93-107
Publication
First Author: Lewis ML
Year: 2000
Journal: Gene
Title: FePer 1, a gene encoding an evolutionarily conserved 1-Cys peroxiredoxin in buckwheat (Fagopyrum esculentum Moench), is expressed in a seed-specific manner and induced during seed germination.
Volume: 246
Issue: 1-2
Pages: 81-91
Protein Domain
Type: Family
Description: This subfamily of peroxiredoxin (known as 1-cys PRX) composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by reducing and detoxifying hydrogen peroxide, peroxynitrite, and organic hydroperoxides []. As with all other PRXs, a cysteine sulfenic acid intermediate is formed upon reaction of 1-cys PRX with its substrates. Having no resolving cysteine, the oxidized enzyme is resolved by an external small-molecule or protein reductant such as thioredoxin or glutaredoxin. Similar to typical 2-cys PRX, 1-cys PRX forms a functional dimeric unit with a B-type interface, as well as a decameric structure which is stabilized in the reduced form of the enzyme. Other oligomeric forms, tetramers and hexamers, have also been reported [, , ]. Mammalian 1-cys PRX is localized cellularly in the cytosol and is expressed at high levels in brain, eye, testes and lung []. The seed-specific plant 1-cys PRXs protect tissues from reactive oxygen species during desiccation and are also called rehydrins [, ].
Publication
First Author: Manevich Y
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.
Volume: 101
Issue: 11
Pages: 3780-5
Publication
First Author: Cha MK
Year: 1995
Journal: J Biol Chem
Title: Thioredoxin-linked "thiol peroxidase" from periplasmic space of Escherichia coli.
Volume: 270
Issue: 48
Pages: 28635-41
Publication
First Author: Takahashi T
Year: 2002
Journal: Dev Genes Evol
Title: An orphan PRD class homeobox gene expressed in mouse brain and limb development.
Volume: 212
Issue: 6
Pages: 293-7
Publication
First Author: Sun HN
Year: 2018
Journal: Mol Med Rep
Title: Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice.
Volume: 18
Issue: 2
Pages: 2427-2432
Publication
First Author: Park YH
Year: 2017
Journal: BMB Rep
Title: Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence.
Volume: 50
Issue: 10
Pages: 528-533
Publication
First Author: Han YH
Year: 2012
Journal: BMB Rep
Title: Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.
Volume: 45
Issue: 10
Pages: 560-4
Publication  
First Author: Park J
Year: 2020
Journal: Antioxidants (Basel)
Title: Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice.
Volume: 9
Issue: 8
Publication
First Author: Shichita T
Year: 2012
Journal: Nat Med
Title: Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.
Volume: 18
Issue: 6
Pages: 911-7
Publication
First Author: Martin JF
Year: 2000
Journal: Genesis
Title: Identification of a prx1 limb enhancer.
Volume: 26
Issue: 4
Pages: 225-9
Publication
First Author: Chesterman ES
Year: 2001
Journal: Dev Dyn
Title: Investigation of Prx1 protein expression provides evidence for conservation of cardiac-specific posttranscriptional regulation in vertebrates.
Volume: 222
Issue: 3
Pages: 459-70
Publication
First Author: Balic A
Year: 2009
Journal: Dev Dyn
Title: Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.
Volume: 238
Issue: 10
Pages: 2599-613
Publication
First Author: Kim SU
Year: 2011
Journal: Neurobiol Aging
Title: Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage.
Volume: 32
Issue: 6
Pages: 1054-68
Publication
First Author: Kwon TH
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Reactive oxygen species mediated DNA damage is essential for abnormal erythropoiesis in peroxiredoxin II(-/-) mice.
Volume: 424
Issue: 1
Pages: 189-95
Publication
First Author: Schweizer U
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Volume: 111
Issue: 29
Pages: 10526-31
Publication
First Author: Papadia S
Year: 2008
Journal: Nat Neurosci
Title: Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Volume: 11
Issue: 4
Pages: 476-87
Publication
First Author: Wood ZA
Year: 2003
Journal: Trends Biochem Sci
Title: Structure, mechanism and regulation of peroxiredoxins.
Volume: 28
Issue: 1
Pages: 32-40
Publication
First Author: Lee TH
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of the mouse peroxiredoxin V gene.
Volume: 270
Issue: 2
Pages: 356-62
Publication
First Author: Lee TH
Year: 1999
Journal: Gene
Title: Characterization of mouse peroxiredoxin I genomic DNA and its expression.
Volume: 239
Issue: 2
Pages: 243-50
Publication
First Author: Lim MJ
Year: 1998
Journal: Gene
Title: The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution.
Volume: 216
Issue: 1
Pages: 197-205
Publication
First Author: Chang TS
Year: 2004
Journal: J Biol Chem
Title: Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.
Volume: 279
Issue: 49
Pages: 50994-1001
Publication
First Author: Lee TH
Year: 1999
Journal: Gene
Title: Characterization of the murine gene encoding 1-Cys peroxiredoxin and identification of highly homologous genes.
Volume: 234
Issue: 2
Pages: 337-44
Publication
First Author: ten Berge D
Year: 2001
Journal: Development
Title: Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.
Volume: 128
Issue: 15
Pages: 2929-38
Publication
First Author: ten Berge D
Year: 1998
Journal: Development
Title: Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs.
Volume: 125
Issue: 19
Pages: 3831-42
Publication
First Author: Kim SU
Year: 2013
Journal: J Neuroimmunol
Title: Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation.
Volume: 259
Issue: 1-2
Pages: 26-36
Publication
First Author: Kim SU
Year: 2014
Journal: Stem Cells
Title: Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.
Volume: 32
Issue: 4
Pages: 998-1011
Publication
First Author: Sun HN
Year: 2019
Journal: In Vivo
Title: Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice.
Volume: 33
Issue: 3
Pages: 749-755
Publication
First Author: Han YH
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Volume: 529
Issue: 3
Pages: 635-641
Publication
First Author: Han B
Year: 2016
Journal: Oncotarget
Title: Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Volume: 7
Issue: 42
Pages: 68044-68056
Publication
First Author: Jin MH
Year: 2020
Journal: Mol Med Rep
Title: Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway.
Volume: 22
Issue: 3
Pages: 1831-1838
Publication
First Author: Li B
Year: 2004
Journal: Genes Dev
Title: Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.
Volume: 18
Issue: 15
Pages: 1824-37
Publication
First Author: Inoue K
Year: 2009
Journal: Int Immunopharmacol
Title: Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.
Volume: 9
Issue: 11
Pages: 1281-8
Publication
First Author: Kikuchi N
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I.
Volume: 45
Issue: 3
Pages: 600-9
Publication
First Author: Kang DH
Year: 2017
Journal: Nat Commun
Title: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Volume: 8
Issue: 1
Pages: 40
Publication
First Author: Furuta T
Year: 2008
Journal: Eur J Immunol
Title: Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin.
Volume: 38
Issue: 5
Pages: 1341-50
Publication  
First Author: Bennett TM
Year: 2023
Journal: G3 (Bethesda)
Title: Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.
Volume: 13
Issue: 5
Publication  
First Author: Collins JA
Year: 2021
Journal: Free Radic Biol Med
Title: Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Volume: 166
Pages: 90-103
Publication
First Author: Park YH
Year: 2016
Journal: Oncogene
Title: Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Volume: 35
Issue: 27
Pages: 3503-13
Publication
First Author: Cho CS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells.
Volume: 111
Issue: 33
Pages: 12043-8
Publication
First Author: Bergwerff M
Year: 2000
Journal: Virchows Arch
Title: Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus.
Volume: 436
Issue: 1
Pages: 12-9
Publication
First Author: Bast A
Year: 2010
Journal: Free Radic Biol Med
Title: Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages.
Volume: 49
Issue: 12
Pages: 1881-91
Publication
First Author: Liu W
Year: 2005
Journal: Dev Biol
Title: Threshold-specific requirements for Bmp4 in mandibular development.
Volume: 283
Issue: 2
Pages: 282-93
Publication
First Author: Iuchi Y
Year: 2009
Journal: Biochem J
Title: Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.
Volume: 419
Issue: 1
Pages: 149-58
Publication
First Author: Bae SH
Year: 2009
Journal: Antioxid Redox Signal
Title: Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia.
Volume: 11
Issue: 5
Pages: 937-48
Publication
First Author: Peskin AV
Year: 2016
Journal: J Biol Chem
Title: Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin.
Volume: 291
Issue: 6
Pages: 3053-62
Publication
First Author: Lee TH
Year: 2003
Journal: Blood
Title: Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice.
Volume: 101
Issue: 12
Pages: 5033-8
Publication
First Author: Kim KM
Year: 2019
Journal: Exp Mol Med
Title: Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation.
Volume: 51
Issue: 6
Pages: 1-11
Publication
First Author: Moon EY
Year: 2006
Journal: Immunol Lett
Title: T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene.
Volume: 102
Issue: 2
Pages: 184-90
Publication
First Author: Han YH
Year: 2005
Journal: FEBS Lett
Title: Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence.
Volume: 579
Issue: 21
Pages: 4897-902
Publication  
First Author: Park SJ
Year: 2018
Journal: Free Radic Biol Med
Title: Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.
Volume: 123
Pages: 96-106
Publication
First Author: Han YH
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Volume: 426
Issue: 3
Pages: 427-32
Publication
First Author: Yang CS
Year: 2007
Journal: J Exp Med
Title: Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock.
Volume: 204
Issue: 3
Pages: 583-94
Publication
First Author: Kang DH
Year: 2013
Journal: Circulation
Title: Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization.
Volume: 128
Issue: 8
Pages: 834-44
Publication
First Author: Scott KK
Year: 2003
Journal: DNA Cell Biol
Title: GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein.
Volume: 22
Issue: 2
Pages: 95-105
Publication
First Author: Choi MH
Year: 2005
Journal: Nature
Title: Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Volume: 435
Issue: 7040
Pages: 347-53
Publication
First Author: Lu X
Year: 2011
Journal: J Bone Miner Res
Title: Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation.
Volume: 26
Issue: 1
Pages: 209-19
Publication
First Author: Leussink B
Year: 1995
Journal: Mech Dev
Title: Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain.
Volume: 52
Issue: 1
Pages: 51-64
Publication
First Author: Ishii T
Year: 2004
Journal: Circ Res
Title: Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.
Volume: 94
Issue: 5
Pages: 609-16
Publication
First Author: Graves JA
Year: 2009
Journal: J Biol Chem
Title: Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc.
Volume: 284
Issue: 10
Pages: 6520-9
Publication
First Author: Diet A
Year: 2007
Journal: J Biol Chem
Title: Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages.
Volume: 282
Issue: 50
Pages: 36199-205
Publication
First Author: Wang S
Year: 2010
Journal: Anat Rec (Hoboken)
Title: Localization and expression of peroxiredoxin II in the mouse ovary, oviduct, uterus, and preimplantation embryo.
Volume: 293
Issue: 2
Pages: 291-7
Publication
First Author: Bast A
Year: 2010
Journal: Biochim Biophys Acta
Title: Induction of peroxiredoxin I gene expression by LPS involves the Src/PI3K/JNK signalling pathway.
Volume: 1799
Issue: 5-6
Pages: 402-10
Publication
First Author: Baek JY
Year: 2012
Journal: J Biol Chem
Title: Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2.
Volume: 287
Issue: 1
Pages: 81-9
Publication
First Author: Perkins A
Year: 2014
Journal: Biochemistry
Title: Tuning of peroxiredoxin catalysis for various physiological roles.
Volume: 53
Issue: 49
Pages: 7693-705
Publication
First Author: Mishra M
Year: 2015
Journal: Cancer Lett
Title: The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development.
Volume: 366
Issue: 2
Pages: 150-9
Publication
First Author: Gan Y
Year: 2012
Journal: Antioxid Redox Signal
Title: Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway.
Volume: 17
Issue: 5
Pages: 719-32
Publication
First Author: Agarwal S
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification.
Volume: 113
Issue: 3
Pages: E338-47
Protein
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Publication
First Author: Yim SH
Year: 2011
Journal: J Biol Chem
Title: Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.
Volume: 286
Issue: 45
Pages: 39002-12
Publication
First Author: Kim S
Year: 2016
Journal: J Neurosci
Title: Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.
Volume: 36
Issue: 37
Pages: 9633-46
Publication
First Author: Conway JP
Year: 2006
Journal: J Biol Chem
Title: Dual role of peroxiredoxin I in macrophage-derived foam cells.
Volume: 281
Issue: 38
Pages: 27991-8001
Publication
First Author: Seo MS
Year: 2000
Journal: J Biol Chem
Title: Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate.
Volume: 275
Issue: 27
Pages: 20346-54
Publication
First Author: Kang SW
Year: 1998
Journal: J Biol Chem
Title: Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
Volume: 273
Issue: 11
Pages: 6303-11
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112