The membrane-spanning 4A gene family consists at least of 12 members []. This entry represents member 12 (MS4A12), whose expression is confined to the apical membrane of colonocytes and strictly repressed in all other normal tissue types. MS4A12 is a component of store-operated Ca(2+) (SOC) entry in intestinal cells and a tumour growth-promoting factor in colon cancer [, ].
