Type |
Details |
Score |
Publication |
First Author: |
Simoes DCM |
Year: |
2022 |
Journal: |
J Cell Biol |
Title: |
An integrin axis induces IFN-β production in plasmacytoid dendritic cells. |
Volume: |
221 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Weigert A |
Year: |
2012 |
Journal: |
Blood |
Title: |
HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo. |
Volume: |
120 |
Issue: |
15 |
Pages: |
3001-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gregorio J |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. |
Volume: |
207 |
Issue: |
13 |
Pages: |
2921-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yun TJ |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. |
Volume: |
23 |
Issue: |
5 |
Pages: |
852-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daissormont IT |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. |
Volume: |
109 |
Issue: |
12 |
Pages: |
1387-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Babcock RL |
Year: |
2022 |
Journal: |
Mol Immunol |
Title: |
Regulation and function of Id2 in plasmacytoid dendritic cells. |
Volume: |
148 |
|
Pages: |
6-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu T |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells. |
Volume: |
202 |
Issue: |
9 |
Pages: |
2529-2534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Björck P |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset. |
Volume: |
186 |
Issue: |
3 |
Pages: |
1477-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodrigues PF |
Year: |
2018 |
Journal: |
Nat Immunol |
Title: |
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells. |
Volume: |
19 |
Issue: |
7 |
Pages: |
711-722 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Keeffe M |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells. |
Volume: |
188 |
Issue: |
8 |
Pages: |
3774-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sathaliyawala T |
Year: |
2010 |
Journal: |
Immunity |
Title: |
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. |
Volume: |
33 |
Issue: |
4 |
Pages: |
597-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abbas A |
Year: |
2020 |
Journal: |
Nat Immunol |
Title: |
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection. |
Volume: |
21 |
Issue: |
9 |
Pages: |
983-997 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao W |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. |
Volume: |
9 |
Issue: |
10 |
Pages: |
1157-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okuya K |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome. |
Volume: |
184 |
Issue: |
12 |
Pages: |
7092-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sichien D |
Year: |
2016 |
Journal: |
Immunity |
Title: |
IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively. |
Volume: |
45 |
Issue: |
3 |
Pages: |
626-640 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chopin M |
Year: |
2019 |
Journal: |
Immunity |
Title: |
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT. |
Volume: |
50 |
Issue: |
1 |
Pages: |
77-90.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Talukder AH |
Year: |
2012 |
Journal: |
Cell Res |
Title: |
Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1129-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lau CM |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells. |
Volume: |
215 |
Issue: |
9 |
Pages: |
2265-2278 |
|
•
•
•
•
•
|
Publication |
First Author: |
Esashi E |
Year: |
2008 |
Journal: |
Immunity |
Title: |
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. |
Volume: |
28 |
Issue: |
4 |
Pages: |
509-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li HS |
Year: |
2012 |
Journal: |
Blood |
Title: |
The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. |
Volume: |
120 |
Issue: |
22 |
Pages: |
4363-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stolp B |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models. |
Volume: |
38 |
Issue: |
7 |
Pages: |
110387 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macal M |
Year: |
2018 |
Journal: |
Immunity |
Title: |
Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection. |
Volume: |
48 |
Issue: |
4 |
Pages: |
730-744.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitsuhashi Y |
Year: |
2012 |
Journal: |
Blood |
Title: |
Regulation of plasmacytoid dendritic cell responses by PIR-B. |
Volume: |
120 |
Issue: |
16 |
Pages: |
3256-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu D |
Year: |
2016 |
Journal: |
Immunity |
Title: |
Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function. |
Volume: |
44 |
Issue: |
6 |
Pages: |
1325-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen YL |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. |
Volume: |
210 |
Issue: |
12 |
Pages: |
2515-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi S |
Year: |
2022 |
Journal: |
Int J Cancer |
Title: |
Fatty acid-binding protein 5 limits the generation of Foxp3+ regulatory T cells through regulating plasmacytoid dendritic cell function in the tumor microenvironment. |
Volume: |
150 |
Issue: |
1 |
Pages: |
152-163 |
|
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•
•
•
•
|
Publication |
First Author: |
Dress RJ |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage. |
Volume: |
20 |
Issue: |
7 |
Pages: |
852-864 |
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•
•
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Publication |
First Author: |
Leylek R |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. |
Volume: |
29 |
Issue: |
11 |
Pages: |
3736-3750.e8 |
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•
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Publication |
First Author: |
Tailor P |
Year: |
2008 |
Journal: |
Blood |
Title: |
The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. |
Volume: |
111 |
Issue: |
4 |
Pages: |
1942-5 |
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•
•
•
•
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Publication |
First Author: |
Hornung V |
Year: |
2005 |
Journal: |
Nat Med |
Title: |
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. |
Volume: |
11 |
Issue: |
3 |
Pages: |
263-70 |
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•
•
•
•
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Publication |
First Author: |
Hitosugi T |
Year: |
2011 |
Journal: |
Mol Cell |
Title: |
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. |
Volume: |
44 |
Issue: |
6 |
Pages: |
864-77 |
|
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•
•
•
•
|
Publication |
First Author: |
Vremec D |
Year: |
2007 |
Journal: |
Blood |
Title: |
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. |
Volume: |
109 |
Issue: |
3 |
Pages: |
1165-73 |
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•
•
•
•
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Publication |
First Author: |
Toma-Hirano M |
Year: |
2009 |
Journal: |
Eur J Immunol |
Title: |
Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation. |
Volume: |
39 |
Issue: |
5 |
Pages: |
1344-52 |
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•
•
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Publication |
First Author: |
Gouix E |
Year: |
2009 |
Journal: |
Mol Cell Neurosci |
Title: |
Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation. |
Volume: |
40 |
Issue: |
4 |
Pages: |
463-73 |
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•
•
•
•
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Publication |
First Author: |
Li Q |
Year: |
2011 |
Journal: |
Clin Immunol |
Title: |
The role of interferon alpha in initiation of type I diabetes in the NOD mouse. |
Volume: |
140 |
Issue: |
1 |
Pages: |
3-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bornstein C |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States. |
Volume: |
56 |
Issue: |
6 |
Pages: |
749-62 |
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•
•
•
•
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Publication |
First Author: |
Chopin M |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity. |
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Publication |
First Author: |
Yang Z |
Year: |
2018 |
Journal: |
Nat Cell Biol |
Title: |
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. |
Volume: |
20 |
Issue: |
2 |
Pages: |
186-197 |
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Publication |
First Author: |
Pöysti S |
Year: |
2021 |
Journal: |
Eur J Immunol |
Title: |
Plasmacytoid dendritic cells regulate host immune response to Citrobacter rodentium induced colitis in colon-draining lymph nodes. |
Volume: |
51 |
Issue: |
3 |
Pages: |
620-625 |
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Publication |
First Author: |
Feng J |
Year: |
2022 |
Journal: |
Immunity |
Title: |
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. |
Volume: |
55 |
Issue: |
3 |
Pages: |
405-422.e11 |
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•
•
•
•
|
Publication |
First Author: |
Yeaman SJ |
Year: |
1989 |
Journal: |
Biochem J |
Title: |
The 2-oxo acid dehydrogenase complexes: recent advances. |
Volume: |
257 |
Issue: |
3 |
Pages: |
625-32 |
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•
•
•
•
•
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Publication |
First Author: |
Fujiwara K |
Year: |
1986 |
Journal: |
J Biol Chem |
Title: |
Chicken liver H-protein, a component of the glycine cleavage system. Amino acid sequence and identification of the N epsilon-lipoyllysine residue. |
Volume: |
261 |
Issue: |
19 |
Pages: |
8836-41 |
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•
•
•
•
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Publication |
First Author: |
Behal RH |
Year: |
1989 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cloning and nucleotide sequence of the gene for protein X from Saccharomyces cerevisiae. |
Volume: |
86 |
Issue: |
22 |
Pages: |
8732-6 |
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•
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•
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Protein Domain |
Type: |
Binding_site |
Description: |
The 2-oxo acid dehydrogenase multienzyme complexes []from bacterial andeukaryotic sources catalyze the oxidative decarboxylation of 2-oxo acids tothe corresponding acyl-CoA. These include: Pyruvate dehydrogenase complex (PDC). 2-oxoglutarate dehydrogenase complex (OGDC). Branched-chain 2-oxo acid dehydrogenase complex (BCOADC). These three complexes share a common architecture: they are composed ofmultiple copies of three component enzymes - E1, E2 and E3. E1 is a thiaminepyrophosphate-dependent 2-oxo acid dehydrogenase, E2 a dihydrolipamideacyltransferase, and E3 an FAD-containing dihydrolipamide dehydrogenase. E2 acyltransferases have an essential cofactor, lipoic acid, which iscovalently bound via a amide linkage to a lysine group. The E2 components ofOGCD and BCOACD bind a single lipoyl group, while those of PDC bind either one(in yeast and in Bacillus), two (in mammals), or three (in Azotobacter and inEscherichia coli) lipoyl groups []. In addition to the E2 components of the three enzymatic complexes describedabove, a lipoic acid cofactor is also found in the following proteins: H-protein of the glycine cleavage system (GCS) []. GCS is a multienzymecomplex of four protein components, which catalyzes the degradation ofglycine. H protein shuttles the methylamine group of glycine from the Pprotein to the T protein. H-protein from either prokaryotes or eukaryotesbinds a single lipoic group. Mammalian and yeast pyruvate dehydrogenase complexes differ from that ofother sources, in that they contain, in small amounts, a protein of unknownfunction - designated protein X or component X. Its sequence is closelyrelated to that of E2 subunits and seems to bind a lipoic group []. Fast migrating protein (FMP) (gene acoC) from Ralstonia eutropha (Alcaligenes eutrophus) [].This protein is most probably a dihydrolipamide acyltransferase involved inacetoin metabolism. This signature contains the lipoyl-binding lysine residue. The domain surronding this site is evolutionary related to that around the biotin-binding lysine residue of biotin requiring enzymes. |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
218
![FASTA](model/images/fasta.gif) |
Fragment?: |
true |
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•
•
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Publication |
First Author: |
Priefert H |
Year: |
1991 |
Journal: |
J Bacteriol |
Title: |
Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism. |
Volume: |
173 |
Issue: |
13 |
Pages: |
4056-71 |
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•
•
•
•
|
Publication |
First Author: |
Workman CJ |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
LAG-3 regulates plasmacytoid dendritic cell homeostasis. |
Volume: |
182 |
Issue: |
4 |
Pages: |
1885-91 |
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•
•
•
•
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Publication |
First Author: |
Furuta Y |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. |
Volume: |
12 |
Issue: |
2 |
Pages: |
e0172509 |
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•
•
•
•
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Publication |
First Author: |
Ushikai M |
Year: |
2011 |
Journal: |
Mol Genet Metab |
Title: |
Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. |
Volume: |
102 |
Issue: |
3 |
Pages: |
349-55 |
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•
•
•
•
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Publication |
First Author: |
Jeoung NH |
Year: |
2006 |
Journal: |
Biochem J |
Title: |
Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. |
Volume: |
397 |
Issue: |
3 |
Pages: |
417-25 |
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•
•
•
•
•
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Publication |
First Author: |
Jeoung NH |
Year: |
2008 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. |
Volume: |
295 |
Issue: |
1 |
Pages: |
E46-54 |
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•
•
•
•
•
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Publication |
First Author: |
Blasius AL |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. |
Volume: |
107 |
Issue: |
46 |
Pages: |
19973-8 |
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Publication |
First Author: |
Griffith AD |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
14451 |
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•
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Publication |
First Author: |
Johnson MT |
Year: |
2001 |
Journal: |
Mol Genet Metab |
Title: |
Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. |
Volume: |
74 |
Issue: |
3 |
Pages: |
293-302 |
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•
•
•
•
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Publication |
First Author: |
Sidhu S |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. |
Volume: |
295 |
Issue: |
3 |
Pages: |
H946-H952 |
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•
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Publication |
First Author: |
Srinivasan M |
Year: |
2010 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. |
Volume: |
299 |
Issue: |
6 |
Pages: |
E910-7 |
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•
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Publication |
First Author: |
Pang S |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
Regulation of fasting fuel metabolism by toll-like receptor 4. |
Volume: |
59 |
Issue: |
12 |
Pages: |
3041-8 |
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Publication |
First Author: |
Puttur F |
Year: |
2013 |
Journal: |
PLoS Pathog |
Title: |
Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e1003648 |
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•
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Publication |
First Author: |
Kochs G |
Year: |
2010 |
Journal: |
J Virol |
Title: |
Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. |
Volume: |
84 |
Issue: |
23 |
Pages: |
12344-50 |
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•
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Publication |
First Author: |
Ghosh HS |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. |
Volume: |
211 |
Issue: |
8 |
Pages: |
1623-35 |
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•
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Publication |
First Author: |
Matsumoto T |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma. |
Volume: |
77 |
Issue: |
22 |
Pages: |
6131-6143 |
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•
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Publication |
First Author: |
Pelletier AN |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7. |
Volume: |
188 |
Issue: |
11 |
Pages: |
5561-70 |
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Publication |
First Author: |
Ito R |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells. |
Volume: |
189 |
Issue: |
9 |
Pages: |
4313-20 |
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•
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Publication |
First Author: |
Koda Y |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35. |
Volume: |
129 |
Issue: |
8 |
Pages: |
3201-3213 |
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Publication |
First Author: |
Matta BM |
Year: |
2012 |
Journal: |
J Immunol |
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