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Search results 1 to 100 out of 123 for Gp2

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
2813 | GP2
Type: gene
Organism: human
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Gene
695766 | GP2
Type: gene
Organism: macaque, rhesus
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Gene
171459 | Gp2
Type: gene
Organism: rat
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Gene
442972 | GP2
Type: gene
Organism: dog, domestic
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Gene
741636 | GP2
Type: gene
Organism: chimpanzee
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Gene
531420 | GP2
Type: gene
Organism: cattle
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Protein Coding Gene
MGI:1914383 | Gp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19907495 | J:155098
First Author: Hase K
Year: 2009
Journal: Nature
Title: Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Volume: 462
Issue: 7270
Pages: 226-30
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Publication
27581982 | J:238004
First Author: Iwasaki M
Year: 2016
Journal: J Virol
Title: Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice.
Volume: 90
Issue: 22
Pages: 10102-10112
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Publication
33594081 | J:303507
First Author: Kurashima Y
Year: 2021
Journal: Nat Commun
Title: Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.
Volume: 12
Issue: 1
Pages: 1067
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Publication
15385539 | J:95044
First Author: Yu S
Year: 2004
Journal: J Biol Chem
Title: Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion.
Volume: 279
Issue: 48
Pages: 50274-9
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Publication
32050049 | J:298514
First Author: Kusunose N
Year: 2020
Journal: Genes Cells
Title: Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.
Volume: 25
Issue: 4
Pages: 270-278
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Publication
15325280 | J:92161
First Author: Kobayashi K
Year: 2004
Journal: Biochem Biophys Res Commun
Title: GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome.
Volume: 322
Issue: 2
Pages: 659-64
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Protein Coding Gene
MGP_CAROLIEiJ_G0030375 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032897 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032732 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031643 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013586 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031490 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
Probe: MGI:6781301
Assay Type: RNA in situ
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6781971
Age: postnatal day 3
Image: 4B
Note: Although this is considered a secretory cell marker, expression is also seen in "hybrid" cells that express ciliated cell markers.
Specimen Label: 4B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6781301
Assay Type: RNA in situ
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6781971
Age: postnatal newborn
Image: 4 S1A wt lower
Note: Expression is seen in secretory cells and in "hybrid" cells that express both secretory and ciliated cell markers.
Specimen Label: 4 S1A wt lower
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6781301
Assay Type: RNA in situ
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6781971
Age: postnatal newborn
Image: 4 S1A Pofut<-/-> lower
Note: These mutants lack secretory cells (and, therefore, lack expression in them). Expression is retained in "hybrid" cells that express both secretory and ciliated cell markers.
Specimen Label: 4 S1A Pofut<-/-> lower
Detected: true
Specimen Num: 3
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Publication
22778137 | J:188796
First Author: de Lau W
Year: 2012
Journal: Mol Cell Biol
Title: Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Volume: 32
Issue: 18
Pages: 3639-47
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Publication
22706340 | J:187649
First Author: Kanaya T
Year: 2012
Journal: Nat Immunol
Title: The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Volume: 13
Issue: 8
Pages: 729-36
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Publication
32286221 | J:306246
   
First Author: He M
Year: 2020
Journal: Elife
Title: Chloride channels regulate differentiation and barrier functions of the mammalian airway.
Volume: 9
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Publication
33707780 | J:305472
First Author: Prados A
Year: 2021
Journal: Nat Immunol
Title: Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.
Volume: 22
Issue: 4
Pages: 510-519
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
 
Begin: 22
Description: Pancreatic secretory granule membrane major glycoprotein GP2
Type: chain
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Publication
11958459 | -
First Author: Learmonth GS
Year: 2002
Journal: Arch Virol
Title: The C-terminal regions of the envelope glycoprotein gp2 of equine herpesviruses 1 and 4 are antigenically distinct.
Volume: 147
Issue: 3
Pages: 607-15
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Protein
Q9D733
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
A0A0R4J0B9
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
A0A140LHP0
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Publication
24218560 | -
First Author: Bae B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.
Volume: 110
Issue: 49
Pages: 19772-7
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Publication
20133868 | -
First Author: Cámara B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site.
Volume: 107
Issue: 5
Pages: 2247-52
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Protein Domain
IPR010278 | Varicellovirus_Gp2_glycop
Type: Family
Description: This entry consists of a number of glycoprotein Gp2 sequences mainly found from equine herpesviruses [].
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Protein Domain
IPR032066 | GP3_package
Type: Family
Description: DNA-packaging protein gp3 (terminase small subunit) is involved in DNA packing in bacteriophage. It contains a channel where DNA is bound and passed to DNA-packaging protein gp2 (terminase large subunit) [].
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Protein Domain
IPR035413 | Terminase_L_C
Type: Domain
Description: Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit [, ]. This entry represents the C-terminal domain of the large subunit.Proteins containing this domain include gp2 from Bacillus phage SPP1 [, ].
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Protein Domain
IPR016412 | RNA_pol_inhibitor
Type: Family
Description: This entry represents RNA polymerase inhibitor, including Gp2 from T7-like viruses. Bacterial RNA polymerase inhibitor, which is expressed in the late stage of lytic development, is also essential for continuous synthesis of phage DNA and functions in the packaging of the viral genome into the mature phage particle []. It inhibits the bacterial host RNA polymerase by interacting with the RpoC subunit and inhibiting the formation of a promoter complex [, , ].
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Protein Domain
IPR033329 | SCARF1
Type: Family
Description: The class F scavenger receptor 1 (SCARF1/SREC-I) contains epidermal growth factor (EGF)-like repeats in its extracellular domain, followed by a long C-terminal cytoplasmic tail composed of serine and proline-rich regions. SCARF1 is an endocytic receptor for acetylated low density lipoprotein, HSP70, HSP90, calreticulin, gp96, and GP2 [, , , , ]. Dendritic cells (DCs),macrophages and endothelial cells use SCARF1 to recognize and engulf apoptotic cells via the complement component C1q; this mediates apoptotic cells clearance, antigen clearance and prevents autoimmunity [].
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Publication
10930407 | -
First Author: Gual A
Year: 2000
Journal: J Biol Chem
Title: Functional analysis of the terminase large subunit, G2P, of Bacillus subtilis bacteriophage SPP1.
Volume: 275
Issue: 45
Pages: 35311-9
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Publication
1548711 | -
First Author: Chai S
Year: 1992
Journal: J Mol Biol
Title: Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6. The products of gene 1 and gene 2 are required for pac cleavage.
Volume: 224
Issue: 1
Pages: 87-102
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Publication
12697751 | -
First Author: Camacho AG
Year: 2003
Journal: J Biol Chem
Title: Bacillus subtilis bacteriophage SPP1 DNA packaging motor requires terminase and portal proteins.
Volume: 278
Issue: 26
Pages: 23251-9
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Publication
30877171 | J:275233
First Author: Kimura S
Year: 2019
Journal: J Exp Med
Title: Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.
Volume: 216
Issue: 4
Pages: 831-846
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Protein Domain
IPR006437 | Phage_terminase_lsu
Type: Family
Description: This group of sequences represent a highly divergent family of the large subunit of phage terminase. All members are encoded by phage genomes or within prophage regions of bacterial genomes. This is a distinct family from the phage terminase family represented by .Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase are usually hetero-oligomers composed of a small and a large subunit [, ]. This entry includes the large subunit, including GP2 from Bacillus phage SPP1 [, ].
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Protein Domain
IPR035412 | Terminase_L_N
Type: Domain
Description: This entry represents the N-terminal domain of the large subunit of the terminase protein.Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit. This region possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction. This region is also found in bacterial sequences [, ].Proteins containing this domain include gp2 from Bacillus phage SPP1 [, ].
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Publication
338933 | -
First Author: Hesselbach BA
Year: 1977
Journal: J Virol
Title: I protein: bacteriophage T7-coded inhibitor of Escherichia coli RNA polymerase.
Volume: 24
Issue: 3
Pages: 746-60
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Publication
22819324 | -
First Author: James E
Year: 2012
Journal: Mol Cell
Title: Structural and mechanistic basis for the inhibition of Escherichia coli RNA polymerase by T7 Gp2.
Volume: 47
Issue: 5
Pages: 755-66
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Publication
15145948 | J:91911
First Author: Tamura Y
Year: 2004
Journal: J Biol Chem
Title: Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
Volume: 279
Issue: 30
Pages: 30938-44
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Publication
20686127 | J:163244
First Author: Murshid A
Year: 2010
Journal: J Immunol
Title: Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I.
Volume: 185
Issue: 5
Pages: 2903-17
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Publication
21190681 | -
First Author: Hölzl MA
Year: 2011
Journal: Cell Immunol
Title: The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
Volume: 267
Issue: 2
Pages: 88-93
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Publication
15371419 | -
First Author: Berwin B
Year: 2004
Journal: J Biol Chem
Title: SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.
Volume: 279
Issue: 49
Pages: 51250-7
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Publication
23892722 | J:208237
First Author: Ramirez-Ortiz ZG
Year: 2013
Journal: Nat Immunol
Title: The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.
Volume: 14
Issue: 9
Pages: 917-26
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Publication
25155057 | -
First Author: Murshid A
Year: 2014
Journal: Immunobiology
Title: Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I.
Volume: 219
Issue: 12
Pages: 924-31
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Protein Domain
IPR038715 | RNA_pol_inhibitor_sf
Type: Homologous_superfamily
Description: This entry represents RNA polymerase inhibitor, including Gp2 from T7-like viruses. Bacterial RNA polymerase inhibitor, which is expressed in the late stage of lytic development, is also essential for continuous synthesis of phage DNA and functions in the packaging of the viral genome into the mature phage particle []. It inhibits the bacterial host RNA polymerase by interacting with the RpoC subunit and inhibiting the formation of a promoter complex [, , ].Gp2 folds into a compact globular domain consisting of a three-stranded beta sheet that packs against an α-helix with a beta1beta2alpha1beta3 topology. The central beta2 strand is flanked by antiparallel beta1 and beta3 strands. Positive and negative charges are at opposite sides on the surface of the molecule. Two conserved arginine residues located on one side are important for binding to and inhibition of host RNA polymerase [].
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Publication
28819024 | J:245658
First Author: Gall VA
Year: 2017
Journal: Cancer Res
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