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Search results 201 to 227 out of 227 for Hcn1

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0.019s

Type

Details

Score

Strain

MGI:6268767 | C57BL/6J-Hcn1<M1Btlr>

Attribute String:

mutant strain, chemically induced mutation, coisogenic

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Genotype

Symbol:	Hcn1/Hcn1
Background:	C57BL/6J-Hcn1
Zygosity:	hm
Has Mutant Allele:	true

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GO Term

GO:0098855 | HCN channel complex

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Publication

30877792 | J:274719

First Author:	Zobeiri M
Year:	2019
Journal:	Cereb Cortex
Title:	The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.

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Publication

25201528 | J:214796

First Author:	Kupferman JV
Year:	2014
Journal:	Cell
Title:	Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Volume:	158
Issue:	6
Pages:	1335-1347

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Publication

30079889 | J:269821

First Author:	Qiu J
Year:	2018
Journal:	Elife
Title:	Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.
Volume:	7

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Publication

23305677 | J:198074

First Author:	Bosch MA
Year:	2013
Journal:	Mol Cell Endocrinol
Title:	mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol.
Volume:	367
Issue:	1-2
Pages:	85-97

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Publication

11459060 | -

First Author:	Wainger BJ
Year:	2001
Journal:	Nature
Title:	Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Volume:	411
Issue:	6839
Pages:	805-10

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Publication

12161074 | -

First Author:	Biel M
Year:	2002
Journal:	Trends Cardiovasc Med
Title:	Cardiac HCN channels: structure, function, and modulation.
Volume:	12
Issue:	5
Pages:	206-12

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Publication

11248683 | -

First Author:	Moosmang S
Year:	2001
Journal:	Eur J Biochem
Title:	Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Volume:	268
Issue:	6
Pages:	1646-52

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Publication

18953682 | -

First Author:	Wahl-Schott C
Year:	2009
Journal:	Cell Mol Life Sci
Title:	HCN channels: structure, cellular regulation and physiological function.
Volume:	66
Issue:	3
Pages:	470-94

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Publication

11102480 | -

First Author:	Petrecca K
Year:	2000
Journal:	J Neurosci
Title:	Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Volume:	20
Issue:	23
Pages:	8736-44

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Publication

12923176 | J:113938

First Author:	Sampson LJ
Year:	2003
Journal:	J Biol Chem
Title:	Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1.
Volume:	278
Issue:	43
Pages:	41988-97

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Protein Domain

IPR030169 | K/Na_HCN1

Type:

Family

Description:

This entry represents HCN1, which belongs to the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channel family. HCN1 is expressed in the brain, spinal cord, dorsal root ganglion and heart muscle []. It contributes to the native pacemaker currents in heart and in neurons [, , ]. It may be involved in motor learning and hippocampal-dependent network oscillation in mice [, ]. It binds to filaminA, a putative cytoplasmic scaffold protein that binds actin and links transmembrane proteins, such as the K+ channels Kv4.2 and Kir2.1, to the actin cytoskeleton [, , ].The hyperpolarisation-activated cation current (termed I(f), I(h), or I(q)) plays a key role in the initiation and modulation of cardiac and neuronal pacemaker depolarisations. This current is carried by both K+ and Na+ through I(h) or I(f) channels, such as members of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) family. HCN channels belong to the superfamilyof voltage-gated pore loop channels. The voltage-dependent opening ofthe HCN channels is directly regulated by the binding ofcAMP. In vertebrates, the HCN channel family comprises four members (HCN1-4) []. Whereas HCN3 seems to be specifically expressed in neurons, the other three channels (HCN1, 2, and 4) have been detected in both heart and brain [, ]. HCN channels contain six membrane-spanning helices (S1-S6), including a positively charged voltage-sensing S4 segment and an ion-conducting pore between S5 and S6. In the C terminus the channels carry a cyclic nucleotide-binding domain (CNBD) []. Binding of cAMP to the CNBD speeds up channel opening and shifts the voltage-dependence of activation to more positive voltages []. HCN channels exhibit weak selectivity for potassium over sodium ions.

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Publication

28363781 | J:244073

First Author:	Eroli F
Year:	2017
Journal:	Neuroscience
Title:	Hyperpolarization-activated current I_h in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1.
Volume:	351

Pages:	47-64

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Publication

29879376 | J:283930

First Author:	Silbernagel N
Year:	2018
Journal:	FASEB J
Title:	The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
Volume:	32
Issue:	11
Pages:	6159-6173

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Publication

17601992 | J:126574

First Author:	Sauerhöfer S
Year:	2007
Journal:	Diabetes
Title:	L-carnosine, a substrate of carnosinase-1, influences glucose metabolism.
Volume:	56
Issue:	10
Pages:	2425-32

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Publication

29375299 | J:285697

First Author:	Stieglitz MS
Year:	2017
Journal:	Front Mol Neurosci
Title:	Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
Volume:	10

Pages:	436

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Publication

23516534 | J:200188

First Author:	Bonin RP
Year:	2013
Journal:	PLoS One
Title:	Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice.
Volume:	8
Issue:	3
Pages:	e58679

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Publication

35002623 | J:321658

First Author:	Deng PY
Year:	2021
Journal:	Front Mol Neurosci
Title:	Hyperexcitability of Sensory Neurons in Fragile X Mouse Model.
Volume:	14

Pages:	796053

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Publication

31410614 | J:298522

First Author:	Ison JR
Year:	2019
Journal:	J Assoc Res Otolaryngol
Title:	Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups.
Volume:	20
Issue:	6
Pages:	565-577

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Publication

32269286 | J:331674

First Author:	Lee SY
Year:	2020
Journal:	Exp Mol Med
Title:	PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors.
Volume:	52
Issue:	4
Pages:	604-614

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Publication

36745683 | J:336290

First Author:	Szegedi V
Year:	2023
Journal:	PLoS Biol
Title:	HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex.
Volume:	21
Issue:	2
Pages:	e3002001

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Publication

27670841 | J:303007

First Author:	Oginsky MF
Year:	2017
Journal:	J Cell Physiol
Title:	Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model.
Volume:	232
Issue:	5
Pages:	1151-1164

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Publication

30459593 | J:288609

First Author:	Shen H
Year:	2018
Journal:	Front Aging Neurosci
Title:	Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice.
Volume:	10

Pages:	353

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Publication

31290157 | J:302875

First Author:	Lainez S
Year:	2019
Journal:	J Physiol
Title:	HCN3 ion channels: roles in sensory neuronal excitability and pain.
Volume:	597
Issue:	17
Pages:	4661-4675

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Protein

O88704

Organism:	Mus musculus/domesticus
Length:	910
Fragment?:	false

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