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Search results 1 to 100 out of 375 for Lyst

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Categories

Hits by Pathway

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Hits by Category

Type Details Score
Gene
1130 | LYST
Type: gene
Organism: human
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Gene
281072 | LYST
Type: gene
Organism: cattle
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Gene
421514 | LYST
Type: gene
Organism: chicken
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Gene
100150726 | lyst
Type: gene
Organism: zebrafish
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Gene
718051 | LYST
Type: gene
Organism: macaque, rhesus
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Gene
779601 | lyst
Type: gene
Organism: frog, western clawed
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Gene
85419 | Lyst
Type: gene
Organism: rat
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Gene
479195 | LYST
Type: gene
Organism: dog, domestic
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Gene
457838 | LYST
Type: gene
Organism: chimpanzee
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Protein Domain
IPR030464 | LYST
Type: Family
Description: Lysosomal-trafficking regulator (LYST) is a large BEACH domain-containing protein that affects lysosome size and quantity []. LYST controls the terminal maturation of perforin-containing vesicles into secretory granules []. Mutations in the LYST gene causes Chediak-Higashi syndrome, which is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction [, ].
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Protein Coding Gene
MGI:107448 | Lyst
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8717042 | J:34205
First Author: Barbosa MD
Year: 1996
Journal: Nature
Title: Identification of the homologous beige and Chediak-Higashi syndrome genes.
Volume: 382
Issue: 6588
Pages: 262-5
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Publication
- | J:106124
     
First Author: Gwynn B
Year: 2006
Journal: MGI Direct Data Submission
Title: ENU induced mutation at Lyst locus
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Publication
25216107 | -
First Author: Holland P
Year: 2014
Journal: Traffic
Title: LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis.
Volume: 15
Issue: 12
Pages: 1390-405
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Publication
25425525 | -
First Author: Sepulveda FE
Year: 2015
Journal: Traffic
Title: LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.
Volume: 16
Issue: 2
Pages: 191-203
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Publication
9070932 | J:38568
First Author: Misumi DJ
Year: 1997
Journal: Genomics
Title: The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.
Volume: 40
Issue: 1
Pages: 147-50
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Publication
- | J:107049
     
First Author: Samples RM
Year: 2006
Journal: MGI Direct Data Submission
Title: Beige 16 Jackson: a remutation of the Lyst gene
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Publication
30157418 | J:270751
First Author: Lyst MJ
Year: 2018
Journal: Cell Rep
Title: Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2.
Volume: 24
Issue: 9
Pages: 2213-2220
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Publication
- | J:143165
     
First Author: Blasius AL
Year: 2009
Journal: MGI Direct Data Submission
Title: Charlotte gray is an allele of Lyst and displays pigmentation defects: Record for "charlotte gray" updated January 9th, 2009
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Publication
27881733 | J:238720
First Author: Westphal A
Year: 2017
Journal: J Exp Med
Title: Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses.
Volume: 214
Issue: 1
Pages: 227-244
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Publication
35239671 | J:322530
First Author: Ji X
Year: 2022
Journal: PLoS One
Title: Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.
Volume: 17
Issue: 3
Pages: e0254469
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Publication
19029039 | J:173521
First Author: Trantow CM
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome.
Volume: 50
Issue: 3
Pages: 1205-14
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Publication
23770565 | J:203745
First Author: Lyst MJ
Year: 2013
Journal: Nat Neurosci
Title: Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.
Volume: 16
Issue: 7
Pages: 898-902
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Publication
- | J:85200
     
First Author: Peters LL
Year: 2003
Journal: MGI Direct Data Submission
Title: A remutation at the beige (Lyst) locus arising in an ethylnitrosourea mutagenesis screen
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Protein
Q3US13
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Publication
24521565 | -
First Author: Shimazaki H
Year: 2014
Journal: J Neurol Neurosurg Psychiatry
Title: Autosomal-recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation.
Volume: 85
Issue: 9
Pages: 1024-8
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Publication
16518687 | J:106442
First Author: Runkel F
Year: 2006
Journal: Mamm Genome
Title: Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25.
Volume: 17
Issue: 3
Pages: 203-10
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Publication
- | J:133617
     
First Author: Eidenschenk C
Year: 2008
Journal: MGI Direct Data Submission
Title: Grey wolf is an allele of Lyst and a model for Chediak-Higashi Syndrome
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Publication
- | J:133616
     
First Author: Rutschmann S
Year: 2008
Journal: MGI Direct Data Submission
Title: Souris is an allele of Lyst and is a model for Chediak-Higashi Syndrome
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Protein
Q8BN38
Organism: Mus musculus/domesticus
Length: 1310  
Fragment?: true
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Protein
Q3TV54
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: true
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Protein
Q3U4C2
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: true
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Protein
Q8BQ04
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: true
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Protein
P97412
Organism: Mus musculus/domesticus
Length: 3788  
Fragment?: false
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Protein
G5E8Q0
Organism: Mus musculus/domesticus
Length: 3787  
Fragment?: false
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Publication
- | J:265211
     
First Author: Prince L
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for charcoal.
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Publication
- | J:281218
     
First Author: Ishikawa A
Year: 2019
Journal: MGI Direct Data Submission
Title: A new spontaneous mutant allele at the lysosomal trafficking regulator locus in mice.
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Publication
- | J:234265
     
First Author: Reyna C
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for charzard
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Publication
- | J:234242
     
First Author: Reyna C
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for vulpix
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Publication
31043676 | J:279894
First Author: Hedberg-Buenz A
Year: 2019
Journal: Sci Rep
Title: Mouse models and strain-dependency of Chédiak-Higashi syndrome-associated neurologic dysfunction.
Volume: 9
Issue: 1
Pages: 6752
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Publication
10527680 | J:59533
First Author: Introne W
Year: 1999
Journal: Mol Genet Metab
Title: Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome.
Volume: 68
Issue: 2
Pages: 283-303
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Publication
21878672 | J:178382
First Author: Jessen B
Year: 2011
Journal: Blood
Title: Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Volume: 118
Issue: 17
Pages: 4620-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0018230 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020194 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020180 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020624 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019281 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019579 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019280 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019088 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9215680 | J:41390
First Author: Barbosa MD
Year: 1997
Journal: Hum Mol Genet
Title: Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.
Volume: 6
Issue: 7
Pages: 1091-8
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Publication
22327079 | J:181844
First Author: Chatterjee P
Year: 2012
Journal: J Immunol
Title: Modulation of antigen presentation and B cell receptor signaling in B cells of beige mice.
Volume: 188
Issue: 6
Pages: 2695-702
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Publication
- | J:217864
     
First Author: Zhang Z
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Swallow
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Publication
8605727 | J:33522
First Author: Jadeski L
Year: 1996
Journal: Clin Exp Metastasis
Title: Exercise and in vivo natural cytotoxicity against tumour cells of varying metastatic capacity.
Volume: 14
Issue: 2
Pages: 138-44
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Publication
- | J:65327
 
First Author: Lane PW
Year: 1962
Journal: Mouse News Lett
Title: bg-beige and bg2J - beige-2J
Volume: 26
Pages: 35
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Publication
- | J:29745
 
First Author: Lovell D
Year: 1981
Journal: Mouse News Lett
Title: A new mutant at the beige locus in mice
Volume: 64
Pages: 49-50
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Publication
- | J:255206
     
First Author: Reyna C
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for robin
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Publication
- | J:215822
     
First Author: Reyna C
Year: 2014
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for 50-cal
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Publication
- | J:220065
     
First Author: Zhang D
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for lightspeed. (Last updated March 25, 2015)
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Publication
1488056 | J:21419
First Author: Gross SK
Year: 1992
Journal: Mol Cell Biochem
Title: The accumulation and metabolism of glycosphingolipids in primary kidney cell cultures from beige mice.
Volume: 118
Issue: 1
Pages: 61-6
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Publication
9368050 | J:44170
First Author: Perou CM
Year: 1997
Journal: J Biol Chem
Title: The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein.
Volume: 272
Issue: 47
Pages: 29790-4
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Publication
9417888 | J:44747
First Author: Davis SG
Year: 1997
Journal: Exp Cell Res
Title: The effect of lysosomotropic amines on beige mouse cells.
Volume: 237
Issue: 1
Pages: 242-5
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Publication
8912013 | J:36682
First Author: Prigent D
Year: 1996
Journal: Inflamm Res
Title: Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse.
Volume: 45
Issue: 10
Pages: 494-8
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Publication
8421432 | J:4023
First Author: Bussiere JL
Year: 1993
Journal: Life Sci
Title: Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice.
Volume: 52
Issue: 4
Pages: PL43-8
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Publication
6467382 | J:7539
First Author: Carlson GA
Year: 1984
Journal: Cell Immunol
Title: Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice.
Volume: 87
Issue: 2
Pages: 348-56
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Publication
12399426 | J:80469
First Author: Kveiborg M
Year: 2002
Journal: Endocrinology
Title: The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.
Volume: 143
Issue: 11
Pages: 4304-9
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Publication
20061169 | J:158843
First Author: Zhang H
Year: 2010
Journal: Mol Genet Metab
Title: Identification of proteins in the ceroid-like autofluorescent aggregates from liver lysosomes of Beige, a mouse model for human Chediak-Higashi syndrome.
Volume: 99
Issue: 4
Pages: 389-95
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Publication
- | J:231804
     
First Author: Daniel C
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for machamp
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Publication
- | J:181
 
First Author: Lyon MF
Year: 1965
Journal: Mouse News Lett
Title: [Slate allelic to beige.]
Volume: 33
Pages: 29
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Publication
- | J:29743
 
First Author: Chase HB
Year: 1965
Journal: Mouse News Lett
Title: Change of symbol - slate
Volume: 33
Pages: 17
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Publication
- | J:83268
 
First Author: Chase HB
Year: 1959
Journal: Mouse News Lett
Title: List of mutant stocks received from Brown University
Volume: 21
Pages: 21
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Publication
5590154 | J:5078
First Author: Lutzner MA
Year: 1967
Journal: J Hered
Title: Giant granules in leukocytes of the beige mouse.
Volume: 58
Issue: 6
Pages: 299-300
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Publication
4697831 | J:5338
First Author: Oliver C
Year: 1973
Journal: J Histochem Cytochem
Title: Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome.
Volume: 21
Issue: 3
Pages: 218-28
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Publication
489978 | J:6213
First Author: Roder JC
Year: 1979
Journal: J Immunol
Title: The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function.
Volume: 123
Issue: 5
Pages: 2168-73
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Publication
1516572 | J:2387
First Author: Whitney PL
Year: 1992
Journal: Exp Lung Res
Title: Soluble beta-galactoside specific lectin is developmentally regulated in lungs of neonatal black mice and beige mice.
Volume: 18
Issue: 4
Pages: 553-61
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Publication
580786 | J:5992
First Author: Prueitt JL
Year: 1978
Journal: J Lipid Res
Title: Pulmonary surface-active materials in the Chediak-Higashi syndrome.
Volume: 19
Issue: 4
Pages: 410-5
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Publication
6573537 | J:7050
First Author: Malkinson AM
Year: 1983
Journal: J Natl Cancer Inst
Title: Major effect on susceptibility to urethan-induced pulmonary adenoma by a single gene in BALB/cBy mice.
Volume: 70
Issue: 5
Pages: 931-6
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Publication
1548087 | J:37919
First Author: Rasmussen KR
Year: 1992
Journal: Infect Immun
Title: Experimental Cryptosporidium parvum infections in immunosuppressed adult mice.
Volume: 60
Issue: 4
Pages: 1648-52
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Publication
7642266 | J:28292
First Author: Appelberg R
Year: 1995
Journal: Infect Immun
Title: Susceptibility of beige mice to Mycobacterium avium: role of neutrophils.
Volume: 63
Issue: 9
Pages: 3381-7
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Publication
3512758 | J:8207
First Author: Takeuchi K
Year: 1986
Journal: J Exp Med
Title: Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G.
Volume: 163
Issue: 3
Pages: 665-77
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Publication
7658072 | J:28297
First Author: Barthold SW
Year: 1995
Journal: J Infect Dis
Title: Exacerbation of Lyme arthritis in beige mice.
Volume: 172
Issue: 3
Pages: 778-84
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Publication
9922217 | J:53722
First Author: Cavarra E
Year: 1999
Journal: Am J Respir Cell Mol Biol
Title: Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
Volume: 20
Issue: 2
Pages: 264-9
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Publication
8509222 | J:12190
First Author: Kaido T
Year: 1993
Journal: Int J Cancer
Title: Sensitized T lymphocytes render DBA/2 beige mice responsive to IFN alpha/beta therapy of Friend erythroleukemia visceral metastases.
Volume: 54
Issue: 3
Pages: 475-81
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Publication
4601767 | J:5471
First Author: Elin RJ
Year: 1974
Journal: Infect Immun
Title: Infection and immunoglobulin concentrations in Chediak-Higashi mice.
Volume: 10
Issue: 1
Pages: 88-91
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Publication
- | J:30716
     
First Author: Clark EA
Year: 1982
Title: The beige (bg) gene influences the development of autoimmune disease in SB/Le male mice
Pages: 301-6
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Publication
187062 | J:5728
First Author: Oliver JM
Year: 1976
Journal: Am J Pathol
Title: Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome.
Volume: 85
Issue: 2
Pages: 395-418
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Publication
686157 | J:6027
First Author: Swank RT
Year: 1978
Journal: Am J Pathol
Title: Turnover of kidney beta-glucuronidase in normal and Chédiak-Higashi (beige) mice.
Volume: 92
Issue: 3
Pages: 755-72
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Publication
7366733 | J:6301
First Author: Talmadge JE
Year: 1980
Journal: Nature
Title: Role of NK cells in tumour growth and metastasis in beige mice.
Volume: 284
Issue: 5757
Pages: 622-4
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Publication
7366734 | J:6302
First Author: Kärre K
Year: 1980
Journal: Nature
Title: Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice.
Volume: 284
Issue: 5757
Pages: 624-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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