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Search results 401 to 412 out of 412 for Stx1a

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Type Details Score
Protein Domain
IPR030535 | Doc2a/b
Type: Family
Description: Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ].
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Protein
D3Z126
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
P60879
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
D3YZ51
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
Q7TNF0
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
P70169
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
H3BJT3
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
D3YYV2
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
O35527
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
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Protein
D3Z1K1
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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