Type |
Details |
Score |
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion JO20, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Messina A |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
VDAC isoforms in mammals. |
Volume: |
1818 |
Issue: |
6 |
Pages: |
1466-76 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [, , , ]. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.The proteins are composed of between 12 to 16 β-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3) [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu S |
Year: |
1999 |
Journal: |
Biochim Biophys Acta |
Title: |
Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration. |
Volume: |
1452 |
Issue: |
1 |
Pages: |
68-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benz R |
Year: |
1994 |
Journal: |
Biochim Biophys Acta |
Title: |
Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins. |
Volume: |
1197 |
Issue: |
2 |
Pages: |
167-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dihanich M |
Year: |
1990 |
Journal: |
Experientia |
Title: |
The biogenesis and function of eukaryotic porins. |
Volume: |
46 |
Issue: |
2 |
Pages: |
146-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forte M |
Year: |
1987 |
Journal: |
J Bioenerg Biomembr |
Title: |
Molecular genetics of the VDAC ion channel: structural model and sequence analysis. |
Volume: |
19 |
Issue: |
4 |
Pages: |
341-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mannella CA |
Year: |
1992 |
Journal: |
Trends Biochem Sci |
Title: |
The 'ins' and 'outs' of mitochondrial membrane channels. |
Volume: |
17 |
Issue: |
8 |
Pages: |
315-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singulani MP |
Year: |
2020 |
Journal: |
Exp Gerontol |
Title: |
Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease. |
Volume: |
133 |
|
Pages: |
110882 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramos SV |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle. |
Volume: |
15 |
Issue: |
10 |
Pages: |
e0237138 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blachly-Dyson E |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. |
Volume: |
20 |
Issue: |
1 |
Pages: |
62-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naghdi S |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
VDAC2-specific cellular functions and the underlying structure. |
Volume: |
1863 |
Issue: |
10 |
Pages: |
2503-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bay DC |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Phylogenetic and coevolutionary analysis of the β-barrel protein family comprised of mitochondrial porin (VDAC) and Tom40. |
Volume: |
1818 |
Issue: |
6 |
Pages: |
1502-19 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents both eukaryotic mitochondrial porins and Tom40 proteins.Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [, , , ]. The channels adopt an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The eukaryotic mitochondrial porins are β-barrel proteins, composed of between 12 to 16 β-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3) []. They are related to the mitochondrial import receptor subunit Tom40 proteins, sharing a common evolutionary origin and structure [].Tom40 is a mitochondrion outer membrane protein and a component of the TOM (translocator of the outer mitochondrial membrane) complex, which is essential for import of protein precursors into mitochondria []. In Saccharomyces cerevisiae, TOM complex is composed of the subunits Tom70, Tom40, Tom22, Tom20, Tom7, Tom6, and Tom5 [, ]. Tom40 is an integral membrane protein and the main structural component of the protein-conducting channel formed by the TOM complex []. It is stabilised by other components, such as Tom5, Tom6, and Tom7 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
296
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
254
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rapaport D |
Year: |
1999 |
Journal: |
J Cell Biol |
Title: |
Biogenesis of Tom40, core component of the TOM complex of mitochondria. |
Volume: |
146 |
Issue: |
2 |
Pages: |
321-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moczko M |
Year: |
1992 |
Journal: |
FEBS Lett |
Title: |
Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae. |
Volume: |
310 |
Issue: |
3 |
Pages: |
265-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dekker PJ |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. |
Volume: |
18 |
Issue: |
11 |
Pages: |
6515-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Esaki M |
Year: |
2003 |
Journal: |
Nat Struct Biol |
Title: |
Tom40 protein import channel binds to non-native proteins and prevents their aggregation. |
Volume: |
10 |
Issue: |
12 |
Pages: |
988-94 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
118
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Model K |
Year: |
2002 |
Journal: |
J Mol Biol |
Title: |
Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. |
Volume: |
316 |
Issue: |
3 |
Pages: |
657-66 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
361
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
308
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
274
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
73
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|