FYVE and coiled-coil domain-containing protein 1 (FYCO1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction [, ]. FYCO1 contains a 9-amino acid-long F-type LIR (LC3-interacting region) motif, which is essential to facilitate efficient maturation of autophagosomes under basal conditions [].
